Heart Disease Community
Coronary Artery Disease
About This Community:

A community of people with Heart Disease to guide and support your heart-health journey. Ask a question, join a conversation, share experiences: symptoms, nutrition, and management.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

Coronary Artery Disease

Why does a calcified 100% blockage of a coronary artery result in tissue damage the same as an MI?
Related Discussions
7 Comments Post a Comment
Blank
367994_tn?1304957193
When there is a vessel occlusion (100%) the area distal to the blockage does not get sufficient blood/oxygen (ischemia)...  I have 100% blockage of the LAD and collateral vessels form a natural by-pass...  Sometimes when the heart cells are not getting sufficient blood the heart cells go into what is medically referred to as heart cell hibernation. When a vessel is opened to the deprived area the cells may begin to function normally.

An MI (heart attack from a clot, etc.) is an acute condition that usually causes necrotic cell damage (probably a few hour window for no damage with intervention) and a permanent loss of cell functionality.  This can happen with gradual ischemia as well. So a 100% blockage of a coronary artery may or may not result in the same tissue damage as an MI.

Blank
63984_tn?1385441539
The heart cell hibernation explanation you offer should be framed in gold on this site, well said, kenkeith.

I'd offer this as well:
Coreg is one type of drug that, combined with exercise, awakens these cells and changes changes the health of the heart in a very positive way.  My doctor preaches that just taking the drug without exercising daily won't work, it's the combination of drug and exercise that awakens hibernating cells.  I've also had wonderful result of mixing in Ranexa, which maximizes the amount of oxygen the heart tissue can accept.  That being said, none of this works unless aerobic exercise is mixed in.  
Blank
367994_tn?1304957193
"Although the pathophysiological determinants for collateral recruitment are largely unknown, the occurrence is related to prolonged periods of ischemia, duration of occlusion, proximal lesion location, and long-term physical exercise".  
Circulation. 2006;114:e501-e502.)
© 2006 American Heart Association, Inc

You are correct!  Physical exercise has an important role for collateral recruitment as well as duration.
Blank
Post a Comment
To
Top Heart Disease Answerers
63984_tn?1385441539
Blank
Flycaster305
97303, OR
976897_tn?1379171202
Blank
ed34
watford, United Kingdom
Avatar_f_tn
Blank
skydnsr
159619_tn?1318997813
Blank
erijon
Salt Lake City, UT
Avatar_m_tn
Blank
Occupant
IL
11548417_tn?1423126466
Blank
Ger57
Netherlands
Blank
BloodPressure Tracker
Monitor Your Blood Pressure
Start Tracking Now
Blank
HeartRhythm Tracker
Track your Heart Condition
Start Tracking Now
Recent Activity
159619_tn?1318997813
Blank
erijon Is finally getting settled ... Comment
8 hrs ago
63984_tn?1385441539
Blank
Flycaster305 A-fib caused kidney failure... Comment
9 hrs ago
Avatar_f_tn
Blank
remar commented on Watched a classic mov...
Apr 20
Heart Disease Community Resources
RSS Expert Activity
748543_tn?1371753642
Blank
TMJ/TMJ The Connection Between Teet...
Jan 27 by Hamidreza Nassery , DMD, FICOI, FAGDBlank
469720_tn?1388149949
Blank
Abdominal Aortic Aneurysm-treatable... Blank
Oct 04 by Lee Kirksey, MDBlank
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
Top Heart Disease Answerers
63984_tn?1385441539
Blank
Flycaster305
97303, OR
976897_tn?1379171202
Blank
ed34
watford, United Kingdom
Avatar_f_tn
Blank
skydnsr
159619_tn?1318997813
Blank
erijon
Salt Lake City, UT
Avatar_m_tn
Blank
Occupant
IL
11548417_tn?1423126466
Blank
Ger57
Netherlands