Drug Interaction

I am a 39 year old Caucasian male.  Years ago I was placed on cholesterol / blood pressure medicine after my annual physical revealed a high C-Reactive Protein number…Anyway, since then my blood pressure  / cholesterol #’s have been tip top…My doctor even saying “With numbers like this you will live until 100”.  I am currently on 40mg Lisinopril, 40mg of Lovastatin and 360mg of Diltiazem, and a daily low dose aspirin.  Been on this regimen for years now.  I have always taken the Lisinopril and aspirin in the morning and the Lovastatin and Diltiazem together at night.  I am embarrassed to say, I recently noticed that the bottle of Diltiazem says to take in the morning and Lisinopril states to take at night….Well, I decided to finally follow the instructions and that did not work out one bit.  When I took the Diltiazem in the morning, I felt like garbage all day long.  As my understanding is that there is a potential interaction between Lovastatin and Diltiazem is it ok to stay the course with what I have always done since nothing seems to indicate a problem after my annual physical?  Thanks for your time.

[ed34]

Well I think it may be something to do with the Diltiazem. It has a half life of around 5 hours, meaning your 360mg will be down to around 120mg by the time you wake up. During the day this will drop considerably again. You was having the 'peak' while sleeping, so not really noticing it. Now you are feeling the effects while awake and 360mg is a high dose.
You are also taking an ace inhibitor for blood pressure in the morning (lisinopril 40mg) and that will add to the impact.
If you feel rough, I would speak to your Doctor about spreading out your Diltiazem through the day. Perhaps 120mg x 3 a day?  I would also question about taking it the same time as the ace inhibitor.
Is there a reason you are on a calcium channel blocker to control blood pressure?