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Heart Disease  (Expert Forum)
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Drug combinations
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Drug combinations

by rosemary, Sep 21, 1999 12:00AM
I am concerned that a friend is doing herself harm by taking drugs that may not be compatable.  She was prescribed coumadin and is also taking Zanax.  Don't these two drugs counteract each other?

by Cleveland Clinic, MD, Sep 21, 1999 12:00AM
There are many drug interactions with coumadin but Zanax is not one of them.  Of course with all medications your doctor and pharmacist should be aware of all drugs you are taking.  Here is a list of some of the drugs that interact with coumadin.
Known Drug interactions with Warfarin
Increased Effect :

                       Highly Probable

                            Alcohol (if concomitant liver disease)
                            Amiodarone
                            Cimetadine
                            Clofibrate
                            Cotrimoxazole
                            Erythromycin
                            Fluconazole
                            Isoniazid
                            Metronidazole
                            Miconazole
                            Omeprazole
                            Phenylbutazone
                            Piroxicam
                            Propafenone
                            Propanolol
                            Sulfinpyrazone

                       Probable

                            Acetaminophen (Tylenol®)
                            Anabolic steroids
                            Aspirin
                            Chloral Hydrate
                            Ciprofloxacin
                            Dextropropoxyphene
                            Disulriam
                            Quinidine
                            Phenytoin (Dilantin®)
                            Simvastatin
                            Tamoxifen
                            Tetracycline
                            Influenza vaccine

                       Possible

                            Disopyramide
                            5-Fluorouracil
                            Ifosphamide
                            Lovastatin
                            Metolazone
                            Nalidixic Acid
                            Norfloxacin
                            Ofloxacin
                            Topical salicylates
                            Sulindac
                            Tometin

                       Doubtful

                            Cefamandole
                            Cefazolin
                            Gemfibrozil
                            Heparin
                            Indomethacin
                            Sulfisoxazole

Decreased Effect
                        
                       Highly Probably

                            Barbiturates
                            Carbamazepine
                            Chlorodiazepoxide
                            Cholestyramine
                            Griseofulvin
                            Nafcillin
                            Rifampin
                            Sucralfate

                       Probable

                            Dicloxacillin

                       Possible

                            Azathioprine
                            Cyclosporine
                            Etrelinate
                            Trazodone


No Effect
                    
                       Highly Probable

                            Alcohol (if no liver disease)
                            Antacids
                            Atenolol
                            Bumetanide
                            Diflunisal
                            Enoxacin
                            Famotidine
                            Felodipine
                            Fluoxetine
                            Ketorolac
                            Metoprolol
                            Moricizine
                            Naproxen
                            Nitrazepam
                            Nizatidine
                            Psyllium
                            Ranitidine

                       Probable

                            Ibuprofen
                            Ketoconazole
                            Ketoprofen

                       Doubtful

                            Diltiazem
                            Tobacco
                            Vancomycin
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