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Heart Disease  (Expert Forum)
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Factor 5 Leiden questions
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Factor 5 Leiden questions

by jan, Oct 29, 2001 12:00AM
Dear Dr.,
I have mild mitral valve prolapse, mild mitral and tricuspid regurg., IST and NCS (and Raynaud's). I , also, have  a lesion on my brain which my drs. think is a stroke or MS. The lesion is causing various abnormal sensations in rt. side and a seizure disorder. I have just been told by neuro that I need to see a hematologist because I tested positive for Factor 5 Leiden.
I take 12.5 mg of atenolol, Tiazac 180 mg., sodium chloride 1 g.(and  Trileptal 300 mg. 2x’s a day).

My questions are: Does this make the cause of the lesion to be more likely a stroke?  Does the Factor 5 Leiden and the mild  valvular disease cause any risks? The epileptologist asked if the IST could cause me to throw a clot (this was before I was tested for Factor 5 Leiden), can it? Should I tell my cardio or just wait until I see hematologist?
Thank you.

by CCF-M.D.-CRC, Oct 29, 2001 12:00AM
Dear jan,

Factor 5 is a part of the clotting cascade and abnormalities in this factor can lead to an increased risk of blood clots.  Usually these are venous clots but it is possible to have a stroke particularly if there is also a patent foramen ovale (PFO).  Oftentimes coumadin is recommended for individuals with factor V disorders. Inappropriate sinus tachycardia (IST) will not increase stroke risk although afib will.  I would recommend seeing a hematologist for additional blood testing and consideration of coumadin therapy.
Member Comments (2)

by MVP18, Feb 25, 2002 12:00AM
Dear Dr.

        I have recently been diagnosed with mitral valve prolapse.  This worries me because I am an 18 year old female.  I also have asthma which is sometimes difficult to control.  My doc put me on Tiazac because after reviewing my 24-hr Holter he saw I've been having long runs of palpitations.  He recently increased the Tiazac to 180mg, but it's too strong and makes me feel awful.
        
        He mentioned some type of surgical procedure as a last resort.

   My question:  Is it normal at my age to experience such intense and persistent palpitations?  Will this get worse with age?  Is surgery neccessary?
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