Member Comments are provided by individuals and reflect their personal opinions only. Under NO circumstances should you act on any advice or opinion posted in this forum. ALWAYS check with your personal physician before taking any action regarding your health! MedHelp International and our partners, sponsors and affiliates have no obligation to monitor any comments posted on this site, or the content and/or accuracy of such exchanges. MedHelp International does not endorse the views of any user.
Heart Disease (Expert Forum)
High CRP High platelet volume
Answered by
Cleveland - OH
This forum is for questions and support regarding heart issues such as: Angina, Angioplasty, Arrhythmia, Bypass Surgery, Cardiomyopathy, Coronary Artery Disease, Defibrillator, Heart Attack, Heart Disease, High Blood Pressure, Mitral Valve Prolapse, Pacemaker, PAD, Stenosis, Stress Tests.
High CRP High platelet volume
by joslin_joslin, Apr 01, 2005 12:00AM
Here is my latest blood work:
MCV: 77 (lower limit :80)
MPV : 18 (Upper limit :10.4)
Platelets: 159K (Limits 150-450 K)
Vit B12:153 (193-950)
I sometimes get tiny blood from my mouth without any reason. Both my father & brother have similar problem. That is, they get blood from nose.
Now, my problem: high MPV of even 11 or 12 is a cause for concern for stroke/MI. with 18 as my MPV, I should have been dead. How to decrease MPV? I also have GERD. Hence it may be difficult for me to use ASPRIN.
HS C-reactive protein: 4 (safe values are less than 1).
This number is again sky high. I have angina problems from last 18-15 yrs. Now I know it is because of high CRP. My total choles: 175, LDL-120,HDL-40, Trigly-85. BP 115/70. 30 Yrs back I had Rheumatic Fever with swollen joints & heart beating at 140/min. After treating with pennicilin+asprin for 8 weeks, it went away. But, it is possible that it may still be there in some dormant form (occational little aches & pains at joints). Now I do not have any symtom of Rheumatic Fever. Question: what tests are there to eliminate Rheumatic Fever as a possible casuse for increased CRP? what medications are there to decrease CRP??
The reason why I went to DOC: 1. Angina 2: tingling/numbess in left foot fingers from last 4 months. Doc put me on treadmill stress test. I passed in flying colors. He did ultrasonic-cardio on my heart. All are functioning OK with out any blockages. I am still having this daily (tingling/numbess )although no pain. What may be causing this?
MCV: 77 (lower limit :80)
MPV : 18 (Upper limit :10.4)
Platelets: 159K (Limits 150-450 K)
Vit B12:153 (193-950)
I sometimes get tiny blood from my mouth without any reason. Both my father & brother have similar problem. That is, they get blood from nose.
Now, my problem: high MPV of even 11 or 12 is a cause for concern for stroke/MI. with 18 as my MPV, I should have been dead. How to decrease MPV? I also have GERD. Hence it may be difficult for me to use ASPRIN.
HS C-reactive protein: 4 (safe values are less than 1).
This number is again sky high. I have angina problems from last 18-15 yrs. Now I know it is because of high CRP. My total choles: 175, LDL-120,HDL-40, Trigly-85. BP 115/70. 30 Yrs back I had Rheumatic Fever with swollen joints & heart beating at 140/min. After treating with pennicilin+asprin for 8 weeks, it went away. But, it is possible that it may still be there in some dormant form (occational little aches & pains at joints). Now I do not have any symtom of Rheumatic Fever. Question: what tests are there to eliminate Rheumatic Fever as a possible casuse for increased CRP? what medications are there to decrease CRP??
The reason why I went to DOC: 1. Angina 2: tingling/numbess in left foot fingers from last 4 months. Doc put me on treadmill stress test. I passed in flying colors. He did ultrasonic-cardio on my heart. All are functioning OK with out any blockages. I am still having this daily (tingling/numbess )although no pain. What may be causing this?
Doctor's Answer
by Cleveland Clinic, Apr 01, 2005 12:00AM
, Apr 01, 2005 12:00AM
joslin,
With your work up your overall risk of obstructive coronary disease causing your problems is low. If you were treated with Penicilling, the likelyhood of sequlae of rheumatic fever is low. An phycsical exam and/or echo would also help rule out any remaining damage form it.
The MPV is not used in cardiology. The MPV is a reflection of platelet size. It can change in various normal and abnormal physiologic states. Given your history of mucosal bleeding, which seems to be familial, I would want to look at a blood smear of your platelets to see if they had a normal morphology and consider various inherited bleeding disorders such as Glanzmans thrombasthenia or von willebrands disease all of which can be assoicated with abnormal platlet fucntion.
With respect to coronary disease and CRP, statins, aspirin, weight loss and an active lifestlye can lower CRP.
good luck
With your work up your overall risk of obstructive coronary disease causing your problems is low. If you were treated with Penicilling, the likelyhood of sequlae of rheumatic fever is low. An phycsical exam and/or echo would also help rule out any remaining damage form it.
The MPV is not used in cardiology. The MPV is a reflection of platelet size. It can change in various normal and abnormal physiologic states. Given your history of mucosal bleeding, which seems to be familial, I would want to look at a blood smear of your platelets to see if they had a normal morphology and consider various inherited bleeding disorders such as Glanzmans thrombasthenia or von willebrands disease all of which can be assoicated with abnormal platlet fucntion.
With respect to coronary disease and CRP, statins, aspirin, weight loss and an active lifestlye can lower CRP.
good luck
Member Comments (2)
by joslin_joslin, Apr 01, 2005 12:00AM
To: everone
Additional details: I am in mid 40's, treadmill daily for 30 mins, had total choles of 170-180 from last 6 yrs. Guessing that my CRP was always high (may be from last 15 yrs or so) since I had Angina ON & OFF from long time. Thank You very much for your time.
