Heart Disease Community
LDL
About This Community:

A community of people with Heart Disease to guide and support your heart-health journey. Ask a question, join a conversation, share experiences: symptoms, nutrition, and management.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

LDL

My understanding is that the statins with the greatest LDL reducing effect are Crestor, Lipitor, Zocor, and Pravachol, in that order.  I don’t mention Leschol and Mevacor since they appear to be rarely used since recently due to the aforementioned being more powerful.  Do we have any available solid data on the effects of the various individual statins other than LDL reduction?  For example, do we know which ones raise HDL the most?  What about effects on particle size or Lp(a), etc.  I guess really the most important question would be – is any one of these statins more proven than the rest in regards to reducing cardiovascular events?
Related Discussions
3 Comments Post a Comment
Blank
976897_tn?1379171202
I think it's more of which one your body will tolerate the best. Different brands seem to show different side effects in many people. Lipitor in some women have produced breast pains or enlargement and even the manufacturers cannot explain that one. Still, I suppose it's cheaper than plastic surgery. Some statins cause abdominal pains in some people, or nausea or serious muscle cramps and even damage. So I don't think it's just picking the one which you feel has the best affects, it's which one suits your body the best. In most cases I've read about, statins have hardly affected HDL levels, in fact most people have trouble raising them. When statins lower LDL, this automatically makes the HDL a higher proportion than it was. Triglycerides can also be a problem in some people, trying to lower them.
Blank
159619_tn?1318997813
There are all kinds of statins out there, as ed said, you have to find out which one you tolerate. I have been on them for many years as I was unable to lower my LDL with diet and exercise alone. They have worked well and I have had no side effects, but everyone is different. Most of these can be replaced by the generic Simvastatin. It's cheap and is the basis of many of the meds out there. For instance, it's the generic for Zocor plus Vytorin is Simvastatin with Zetia, a Fenofibrate for lowering tri's.

Statins improve blood cholesterol levels primarily by inhibiting a liver enzyme called HMG Co-A reductase, thus reducing the liver's ability to make cholesterol. Statins cause a significant reduction in LDL cholesterol levels, a moderate reduction in triglyceride levels, and a small increase in levels of HDL cholesterol.

Hope it helps,

Jon
Blank
Post a Comment
To
Top Heart Disease Answerers
159619_tn?1318997813
Blank
erijon
Salt Lake City, UT
976897_tn?1379171202
Blank
ed34
watford, United Kingdom
Avatar_f_tn
Blank
skydnsr
63984_tn?1385441539
Blank
Flycaster305
97303, OR
Avatar_m_tn
Blank
Occupant
IL
11548417_tn?1423126466
Blank
Ger57
Netherlands
Blank
BloodPressure Tracker
Monitor Your Blood Pressure
Start Tracking Now
Blank
HeartRhythm Tracker
Track your Heart Condition
Start Tracking Now
Recent Activity
13573062_tn?1430556631
Blank
Dr_JCLU uploaded new photos
May 02
1236893_tn?1408490528
Blank
What Happens to Your Body When You...
May 01 by gymdandee
13553609_tn?1430463123
Blank
kellarn added the Blood Pressure Tracker
May 01
Heart Disease Community Resources
RSS Expert Activity
748543_tn?1371753642
Blank
TMJ/TMJ The Connection Between Teet...
Jan 27 by Hamidreza Nassery , DMD, FICOI, FAGDBlank
469720_tn?1388149949
Blank
Abdominal Aortic Aneurysm-treatable... Blank
Oct 04 by Lee Kirksey, MDBlank
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
Top Heart Disease Answerers
159619_tn?1318997813
Blank
erijon
Salt Lake City, UT
976897_tn?1379171202
Blank
ed34
watford, United Kingdom
Avatar_f_tn
Blank
skydnsr
63984_tn?1385441539
Blank
Flycaster305
97303, OR
Avatar_m_tn
Blank
Occupant
IL
11548417_tn?1423126466
Blank
Ger57
Netherlands