mary,
sorry to hear of your events. Thanks for posting.
1)My prognosis and quality of life in the future.
This is really impossible to comment on. Since you failed coumadin, there is no good data on the benefit of aspirin/plavix over coumadin. I would be interested in making sure the TIA was indeed due to the PFO and not that you happened to have a TIA and the PFO was just a coincidence. Thus, I would be interested to know if you have ever had a documented clot as the source of your emboli to cause the TIA. Also, I would be interested in your coaguabilty profile. Certain conditions associated with TIA/CVA such as antiphospholipid antibodies require coumadin to be dosed higer then normal, thus if this were a cause you could still have symptoms on coumadin.
2)Taking trip to Europe next week I'm worried about the flight
Long flights have been associated with TIA/CVA in patients with PFO's. These are case reports. Either way, you should try to do regular leg exercises and get up occasionally on the flight to decrease the risk of venous thrombus formation given your previous history.
3) Would you reccommend a second Cardio opinion?
Yes. A fresh set of eyes may be helpful in both determining your closure options and if there is any other management option. I might suggest Dr. Tuzcu at the clinic for reviewing your closure options. It might also be helpful to see a vascular medicine specialist to discuss your anticoagulation options.
good luck