PROVIGIL VS MYOCARDITIS

MY DAUGHTER, 22YRS OLD PASSED AWAY OCT 15,2008. MEDICAL EXAMINER DIAGNOSED HER WITH
LYMPHOCYTIC MYOCARDITIS. SHE WAS ON PROVIGIL FOR APPROXIMATELY 1 YEAR FOR NARCOLEPSY.
I HAVE READ THAT PROVIGIL CAN CAUSE MYOCARDITIS OR MULTIORGAN HYPERSENSITIVITY. COULD THIS
PROVIGIL HAVE CAUSED HER DEATH? NOTE: SHE HAD NO COLD OR FLU SYMPTOMS IN THE LAST 6 MONTHS TO LEAVE A VIRUS.

THANK YOU
BOB NUGENT

[Cleveland Clinic]

Sorry for you loss.  Provigil can cause multiorgan failure due to a hypersensitivity reaction but this is more of a generalized contidion that affects all organs and not necessarity the heart only.  On the other hand, it has been reported to cause sudden cardiac death is some children and young adults, but most of them had underlying heart disease such as hypertrophic cardiomyopathy, or congenital coronary artery annomalies or others.  This is something worth looking into.  I have not seen any association between myocarditis and provigil.  Myocarditis does not always present with a viral prodrome and may present with sudden cardiac death as probably was the case with your daughter.  Again, I am very sorry for your loss.