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1274110 tn?1270792161
Ranexa and Heartburn/GERD
59 year old male. Had a heart attack at 37 and triple bypass. Had a double bypass 9 years later. Had to quit work in 2004 because of severe angina and shortness of breath. EF of 40. Was on 60mg of Imdur 2 times a day and nitro patch. Doing EECP every 6 months to keep angina tolerable.  I am a I have been taking 1000 MG of Ranexa twice a day for about 6 weeks. I came off of Imdur 60 mg twice a day and a nitro patch. It was working but now I get real bad heartburn and my GERD (acid reflux) is back. Has any one had a similar experience? Here is a listing of my meds. Any help appreciated.
Medicine Dosage Times/ Day
Ranexa 1000MG 2
Lipitor 40MG 1
Zeita 8MG 1
Cozaar 25MG 1
Coreg 12 1/2MG 2
Lasix 40MG 2
Lovza   4000MG 1
Plavix 75MG 1
Asprin 81MG 1
Glipizide 20MG 1
Allopurinol 100MG 1
Trimethoprim 100MG 1
Cymbalta 90MG 1
Protonix E.C. 40MG 2
Beconase AQ PRN
Lantus 70 units 2
Novolin R Sliding scale PRN
Flaxseed Oil 1000MG 1
Co Q-10 100MG 1
Vision Vitamin 2
Calcium/D 600MG 1
Vitamin D                 1000U                1
Chromium Picolinate 200MCG 1
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4 Answers
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63984 tn?1385441539
I have taken Ranexa for about a year, and along with some of the medications you take.  These include Lipitor, Coreg,  Lasix, Plavix, 81 mg aspirin, Protonix.  I still take Imdur as well.  I have had no increase in GERD or heartburn.  Given the large cocktail of drugs, have you given thought to requesting your pharmacy to key out the possible drug interactions?
I found Ranexa really helps control my angina.  As I understand it, Helps stunned, or oxygen-starved areas of the heart by working with beta blockers.
  
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255163 tn?1376873346
I am on plavix also and was taking nexium for gerd. My cardiologist told me to go off the nexium because the FDA has found that the nexium or any of the PPI's  inhibits the plavix from working properly.  I am now on pepcid instead of nexium.  I am curious to find out if  your cardio's had mentioned  this to you.  Protonix is in the same group of PPI's as nexium.  Google plavix and ppi's or go on the FDA website.  You will read a lot about the two meds.
Just for your info.
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1274110 tn?1270792161
I have talked to the pharmacist about it and since the GERD did not reoccur before I started the Ranexa and came off of the Imdur he thought the Ranexa was the cause. I want to stay on the Renexa becuase it helps the agania better than the Imdur. I am talking to Gastroenterologist about surgery for GERD so I can stay on it. Thanks for your help.
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1274110 tn?1270792161
My cardiologist here in NC and my old one in OH said that Plavix was approved with Prontonix. Thanks for the warning. It might be old information. I was denied Ranexa because of an old warning about the interaction with my Diltizem. Thanks for your help.
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