The condition is vascular injury the underlying cause can be due to a metabolic syndrome, insulin resistance, prediabetes, and overt type 2 diabetes mellitus are associated with an accelerated atherosclerosis (atheroscleropathy).
The common (spontaneous atherosclerosis) pathophysiologic mechanisms, namely, endothelial injury with early platelet involvement and subsequent progressive smooth muscle cell proliferation and thrombosis leading to vascular occlusion. Understanding the mechanisms of this process has made it possible to include strategies to limit vascular injury and reduce subsequent thrombotic and proliferating cellular responses.
In contrast to spontaneous atherosclerosis, a more significant denuding endothelial injury appears to be the critical initiating event, followed by intense platelet involvement and thrombus formation, leading to an initial predominant process of smooth muscle cell proliferation in accelerated atherosclerosis. Risk factors like cigarette smoking and hypertension play an important role in this process.
Atherosclerosis (Atherosclerosis, AS) is a form of vascular endothelial cells (vascular endothelial cell, VEC) damage, vascular smooth muscle cells (vascular smooth muscle cell, VSMC) proliferation as the main pathological features of vascular disease. Endothelial cells (endothelial cell, EC) dysfunction and injury is the initiating AS part of the formation of oxidized low density lipoprotein (oxidized low density lipoprotein, ox-LDL) is recognized as the risk of damage caused by EC one of the factors The VEC produced in addition to direct oxidative damage, promote mononuclear cells (monocyte, MC) and the VEC adhesion to EC dysfunction occurred while AS is active as an important step took place, but also through the signal transduction system, leading to cell production oxidative stress in the formation of AS plays a key role.
Copyright 1994-2016MedHelp International.All rights reserved. MedHelp is a division of Aptus Health.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.