sarcoidosis often affects multiple organ are actually causing organ dysfunction because of redundancy within these organs. For example for his sarcoidosis will always affects the liver pathologically it was never causes liver dysfunction. Sarcoidosis affects primarily the lungs in your case shortness of breath may be related to any lung involvement. But in your case it may also involve the heart since you are having these arrhythmias:that PACs are nothing to be concerned aboutsince these are simply early or atypical atrial depolarizations(these are beats coming from the top chambers are).the PVCs or VPCs is there also called represent early ventricular contractions. These are not significant as long as that don't occur in a sustained fashion: If they occur 4 or more in a row then this is called ventricular tachycardia.this ventricular tachycardia is the feared arrhythmia in patients with sarcoidosis, and it's often difficult to treat. Some patients require antiarrhythmic medications others receive ablation procedures and yet others who did not respond to these procedures require heart transplant. but it doesn't seem as if you have this arrhythmia as your Holter only reported some PVCs. hence you don't need an implantable cardiac defibrillator at this time, but she must be weary of the symptoms of ventricular tachycardia: dizziness, lightheadedness, passing out or sustained palpitations.