Hi gabgab,
There is not strict answer to your question....it depends on the individual. In the hospital we watch for changes in the amount of urine you make, changes in mental status, and changes in some lab values. People with blockages in heart, kidney, gastrointestinal arteries (among others) will suffer symptoms at higher blood pressure than most young healthy people. If this was an accidental overdose, you may want to buy a pill dispensor to help you keep track of medications. You should not change the doses or take extra medications without your doctors supervision--but I am sure you know that.
That is about the best answer I can give. Please becareful with your medications and good luck.