Research shows that 61 out of every 1000 patients on 80mg of simvastatin develop muscle problems. I do believe the half life for Simvastatin is quite short, 5 hours or less. If you take 80mg, then 5hours later only 40mg will remain. Another 5 hours only 20mg. So after 24 hours there will only be around 2-3mg in your body which is top up time.
The numbers vary depending on the study, what Ed is referring to was a recent study of high dose Simvastatin. Your were most likely on a much lower dosage, either 10 mg, 20 mg or 40 mg. 80 mg is normally not prescribed expect in those with heart disease.
The main study for Simvastatin was the 4S trial which proved that the incidence rate for side effects at 40 mg of Simvastatin was 1 in 2,220 prescriptions. What is interesting is that the incidence rate in the placebo group was 1 in 2,223. Also muscle pain is a very common complaint and is a symptom of many conditions.
Ed is correct about the half life, a normal 40 mg dose is out of your system within a day. Also, any side effects are usually gone in a couple days or a week at most. It would be very rare that your muscle pain started after a year as most side effects start within 90 days of starting a statin, but it is not unheard of. If your blood tests were normal it is not likely to be the statin as the current blood tests are very accurate, but everyone is different.
I know it is much to consider, but let the doctor do their job and I'm sure you'll get your answer.
As Ed commented, the drug should have left your body a long time ago. Muscle soreness is a pretty rare but real result from Statin drug use, but I would also question it as a reason for your discomfort. Calf discomfort is a common problem with people who have Peripheral artery disease (PAD). Have you started exercising recently? Twelve years ago when I had my first heart attack and started to walk as an aerobic exercise I would experience very strong calf pain, but continued exercise and a stronger statin coupled with a big weight loss eliminated the problem. Your symptoms, I think should merit additional tests. Keep us informed.
I had all of the classic muscle pains listed in statin side effects documentation. My doctor said it was because of coQ10 and vitamin D deficiency from the statins. She recommended StatinHelp (www.statinhelp.com) that is sold on Amazon. It has really helped with the muscle pains. Statin side effects are never really discussed by the doctors. I found out two years into treatment when I mentioned needing something for back and leg pain to her. By then I was taking 10-15 advil per day to function. Thankfully she was a runner who believed in vitamin supplements.
Pay attention because the statin side effects can creep up over a couple of years.
I did go off statins for a while. It took weeks for muscle issues to go away and I had other strange cramp like issues during the period. I went on a vegan diet but my cholesterol went back up so back on crestor. I've considered asking my doctor about other drugs like zocor or Lipitor also but right now I feel tons better.
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