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T wave inversion
When i was assigned in Angola offshore (about 10 kilometers from shore), one day when I have some fever and headache, cough, etc, because of my fear of Malaria in the area, I took a therapeutic dose of Lariam tablets that means several tablets in one day. Later on, after months, I felt some heaviness on my left chest, on and off.
Since I was working for 12 years overseas, I had history of ST-T wave changes in my previous Medical Fitness Examinations but NO T-wave inversions. ON my last medical check up last November 2011, my ECG showed T-wave inversions on Leads V3-V6. I did Stress Test and this problem was still seen although I tolerated or finished the whole testing (I can swim for 25 meters or more without a problem or walk for kilometers without a problem that time). I also did 2 D Echo of my heart and they found no abnormality. Then they issued me a Fit to Work Medical Fitness Certificate. My questions are: are my T-Wave inversions secondary to Lariam therapeutic dosage or only due to stress (because I stayed 8 months offshore that time?) or both? If my T-wave inversions are secondary to Lariam theraputic dosage I took, what is the treatment or what should I do to relieve this problem?

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Hello and hope you are doing well.

T-wave inversions are normal in a few leads, when in association with a predominantly negative QRS complex. If it is because of Lariam, the changes should have reverted once you stopped therapy. If your stress test was abnormal, the next course would have been an angiogram. As your are asymptomatic and since your stress test was normal, you may not need any therapy now.

Hope this helped and do keep us posted.
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