excessive triglycerides

About 10 years ago, I was diagnosed with hypertriglyceridemia. Nothing seems to work for very long. Lopid never worked. Tricor makes me have SEVERE mood swings. (Depression, suicidal, psycotic) Zocor worked the best of the prescription drugs. But eventually, it stopped working too. I am now on 500 mg niacin, which has worked the longest, but is now useless. My labs drawn last week- cholesterol-150, triglycerides-1711, renal and hepatic panels-normal. I also have MS. Low carb diet (actually NO carb diet) works well but aggravates MS symptoms. High triglycerides run on both sides of the family. Heart disease also runs in the family, but most have lived to be a ripe old age. (With the excetion of my Grandfather, who died of cancer at 54). I do not eat excessive sweets, pasta or bread. As a matter of fact, most days I only eat one meal because of my busy schedule. Please help. My doctors are at a loss. I am open to experimental treatments, but the region where I live is excluded most of the time. Thanks.

[CCF-M.D.-MJM]

sorry to hear about your frustration.  You certainly have tried alot of medications.  Unfortunately, those are all the medications I every use to treat cholesterol and triglycerides. The next step I would take is to refer you to a lipid specialist.  If there isn't one in your area, it may be worth traveling to find one.  Have you tried other statins besides zocor?  You could always try a combination of statin medications and lopid/niacin, but you will require close supervision.

I am also at a bit of a lose, but that is what I would try.  I wish you well and hope you find the answer.