It depends on who you believe and why. In the UK, a man was diagnosed with 9.7mmol/l of total cholesterol which equates to approx 375 in your numbers. He was put on statins which lowered his cholesterol to 5.7, the same as mine now. He decided to go by latest research and cut out sugar from his diet, replacing it with red meat 4 times per week. He came off his statins, waited 3 months, then went for another blood test and it was 5.5 with no medicaion. Now you tell me, is cholesterol to do with heart disease or not? So many trials have been done with statins, but with so much money, I'm sure the big companies can have an influence on the results if you know what I mean. The actual philosophy with heart disease in the UK is gradually changing. Every Doctor questioned said they would never take statins or prescribe them to relatives. Personally, I think statins help in the way of reducing inflamation in arteries, but that's it. Long term though, be prepared for blurred vision, liver issues etc etc. In the uk, the average cholesterol is 5.5 mmol/l and this is being pushed as being too high by the drug companies. They even want children to be taking them. I'm so pleased that Doctors are waking up to the fact that the majority of heart attack victims are in fact in the normal cholesterol range. I don't think the true cause of heart disease has been found yet, but I still have an idea that it is stress related. This is also backed up by our cousins (chimps) being tested. Those under stress were found to have heart disease with a range of cholesterol levels, and those suffering no stress had none. The man I was talking about is a vascular Doctor called Dr Haroun Gajraj. Regular exercise will raise HDL and lower LDL and Trigs. No sugar or low sugar will reduce LDL/Trigs. Raising red meat intake seems to have some benefits too, including making your stomach feel fuller for longer, making you eat less.