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Heart Disease (Expert Forum)
low dose versus med dose aspirin
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low dose versus med dose aspirin
by Le__0__0, Nov 10, 1997 12:00AM
Posted By CCF CARDIO MD sc on November 14, 1997 at 12:13:11:
In Reply to: low dose versus med dose aspirin posted by Lee on November 10, 1997 at 23:43:33:
: I am looking for the literature that would support or refute the use of low dose aspirin in prevention of CAD. What is the optimal preventative dose of ASA? Is there clearly a disadvantage in taking more than 300mg per day?
In Reply to: low dose versus med dose aspirin posted by Lee on November 10, 1997 at 23:43:33:
: I am looking for the literature that would support or refute the use of low dose aspirin in prevention of CAD. What is the optimal preventative dose of ASA? Is there clearly a disadvantage in taking more than 300mg per day?
Doctor's Answer
by CCF Cardio MD sc, Nov 10, 1997 12:00AM
_
Dear Lee
There is considerable debate as to the correct dose of aspirin in the treatment of different cardiovascular conditions. The doses of aspirin used to prevent cardiovascular complications have gradually decreased from initially 1300mg daily for prevention of transient ischemic attacks ( "mini-strokes" ) to 30 mg daily for the same purpose. The concept is that the lower doses have lower side effects. However when discussing aspirin in the context of primary prevention the one major trial that looked into this, "The Physicians Health" study used doses of 300mg every other day.
After myocardial infarction the recommended dose is 325mg/day, and as secondary prevention doses of 165mg /day are recommended. Although not published yet preliminary reports from the CARS trial ( Coumadin Aspirin re-infarction Trial) also suggest that the ideal dose of aspirin is 160-320mg /day.
There appears to be no increased benefit of using higher dose aspirin regimens for primary prevention at this point and doing so would increase the incidence of possible risk factors, thus altering the risk/benefit profile. I hope you find this information of some use. If you have any further questions or would like to see a cardiologist in our prevention clinic please feel to call 1-800-CCF-CARE to set this up.
Information in this forum is intended for general information only, specific diagnosis and treatment should be reserved for physicians involved in patient’s care.
