I understand that you are on HRT, on the lowest dose of estrogen ( CEE) and progesterone ( MPA) possible? Is that correct? If so you should know that the long term follow-up of women with coronary disease who underwent long term HRT ( 4 years) time were found to have increased cardiovascular events during the first year of treatment, after which the two leveled off. In the end there was no benefit from HRT in cardiovascular events, but there was a 25% increase in events during the first year of HRT.
In primary prevention, the Women's health initiative tested women older than yourself for the hypothesis that HRT protected against cancer/fractures or heart disease. This trial found no benefit from the HRT on heart disease, but a decrease in fractures risk, and increase in thromboembolism risk and no change in breast cancer risk over the 7 year period.
The bottom line is that HRT is probably not going to decrease your heart disease risk, but if you have been taking it for over one year isn't likely to increase it either. The HRT doses of estrogen and progestin do not cause major changes in your lipid levels.
Anurag
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