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Autoimmune Hepatitis - I need some help, please...
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Autoimmune Hepatitis - I need some help, please...

Hello,
I am a 39 years old female. I was diagnosed 5 months ago with Type 1 Diabetes and Hashimoto's Disease. I was also checked positive for  SLE and Sjogrens.
For the past 12 months my liver enzimes are elevated (not to much, about 2 or max 3 times normal limits). I have a ANA positive (titer 1:160), ASMA Positive, I had a Liver Biposy done and the results came back as "rare isolated focus of non-caseating granuloma and rare focus of chronic inflammation of lobule with minimal chronic inflammation of portal triads, no accumulation of iron or fibrosis".  My doctor was not able to give me a final diagnosis yet. As I understand my liver biopsy doesn't show that I have AIH so my question is : Is it possible to have ANA positive, ASMA positive, elevated liver enzimes, joint pain, nausea, liver biopsy negative and still don't have AIH?? In this case why do I have ANA and ASMA positive?? Are they signs of something else besides AIH?? Can someone give me some ideas, please??? I want to make an educated decision when I talk to my doctor again, especially taking in consideration the fact that the treatment for AIH will be very hard on my body, as being Diabetic. Thanks for your time!!!
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Avatar_n_tn
has anyone else ever heard of granulomatis hepatitis?  They sat its rare. my ALT/SGPT is36. slightly high My protien level is 9.0    and my ana titer is sky high of 1:640  My sed rate is high at 62, RA factor is sky high of 432my platlet count is low 138 and my absolute eos is low at 0.1    

could someone please help me figure this out and why they are so high
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Avatar_f_tn
Hi Debbie,

Yes it is possible to have autoimmune hep with a negative biopsy. When they do a biopsy they take such a small segment of the liver and maybe the liver in the area of the biopsy was not affected.  I have autoimmune hep and all the things that go with it.
I also have Hashimoto's Thyroid disease.  With High SGOT/ALT they will keep testing.
a positive ANA you definately have autoimmune diseases.  Let me know what further
things they have done for you and how you are doing.

ihbs
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It is so confusing when you deal with the immune issues.  So many tests, so many overlapping symptoms, test results and the treatment for each is so vastly different.  I have checked out several of the different communities and so many of my results could be four or five different immune diseases.  I hope you get answers and better yet treatment and results.  What is the difference between Hishomoto thyroid disease and Hypothyroidism. I was first told Hisho and now told Hypo.  My ANA and other results are close to yours.  Do you have a lot of issues with handling heat, the sun and fatigue?  I melt in the sun, once Fall and Winter kick in, I get a lot of relief, but still can not have very warm shower or many layers of clothes.
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Avatar_f_tn
Hi,
After about 1 year of going to several especialists I've got not one but quite a few diagnosis including Autoimmune Hepatitis. I am currently seeing Dr. Morelli at Shands for the Autoimmune Hepatitis and I am on treatment now for about 8 months... this past January I had my 6 months check-up and I liver enzimes started to climb up again so the doctor double the dose of the Imuran and so far it loos like that the disease is under control. I was tested positive for several other autoimmune diseases (Hashimoto, MCTD overlaping SLE, Autoimmune Hepatitis, Type 1 Diabetes, Lynchen S. , positive for Sjogrens and possible Raynaulds Syndrome). In consequence of the autoimmune diseases I developed a heart condition and few other things that make the list quite extensive ... so far I am managing, having some good and some very bad days but I have 2 good reasons to keep moving forward and do let the diseases to keep me from living a fulfilling life :)
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Avatar_f_tn
Hey!!
Yes, I can trully related your issues with sun and heat. The best time of the year for me are fall and winter... I cannot be directly exposed to the sun without having consequences and also because of all the medications that I am currently taking. My worse flare ups happen in the Summer time. Some days I am so tired that I can't get up and my body ams muscles ache so much that I can't do simple things like comb my hair...
As I understand Hashimoto's disease is a disease, and hypothyroidism is a condition. Hypothyroidism is most commonly caused by Hashimoto's disease, but the two terms are not interchangeable.In Hashimoto's, antibodies react against proteins in the thyroid gland, causing gradual destruction of the gland itself, and making the gland unable to produce the thyroid hormones the body needs. Many people with Hashimoto's disease end up hypothyroid, the situation where the thyroid is either underactive or, eventually, totally unable to function. Keep in touch!!


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