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SA WAKAS!!! FUNCTIONAL CURE FOR CHRONIC HEPA B?
Arrowhead Induces 90% Reduction in Hepatitis B Antigens in Chimpanzee with Chronic Infection: Data Follow Previous Report of Reduction in Viral DNA
-   Through 29 days after initial treatment, maximal knock down of HBV DNA, e-antigen, and s-antigen were approximately 95%, 90%, and 90%, respectively
-   Results discussed today at an analyst event and webcast from 12:30 to 2:00 p.m. EDT
-   Panel members for the event include Dr. Robert Gish, noted hepatologist and Arrowhead Clinical Advisory Board Chairman, and Joan Block, Executive Director and Co-founder of Hepatitis B Foundation
PASADENA, Calif. — March 25, 2013 — Arrowhead Research Corporation (NASDAQ: ARWR), a targeted therapeutics company, will host an analyst event today in New York City to discuss ARC-520, its RNAi-based candidate designed to treat chronic hepatitis B virus infection. The company will discuss the program and describe new preclinical data showing that a low dose of ARC-520 induced rapid and deep reductions in viral particles and key viral antigens in a chimpanzee chronically infected with hepatitis B virus. Arrowhead identified a well-tolerated dose of ARC-520 that lead to a 95% reduction in circulating viral DNA, and approximately 90% reductions in hepatitis e-antigen (HBeAg) and s-antigen (HBsAg), which are thought to be important in establishing a functional cure. These data support previous findings in rodent models and may be predictive of a therapeutic dose range to be identified in upcoming clinical trials expected to start in the middle of this year.
“This is the first time I have tested an siRNA therapy that was efficiently delivered to the liver and suppressed HBV infection including serum levels of HBsAg, a marker that is not suppressed effectively using current therapies,” said Dr. Robert Lanford of the Texas Biomedical Research Institute where the study was conducted. “This was a proof-of-concept study with a novel approach for curing HBV infection and this therapy provided highly promising results in a very short trial.”
The study was designed to test tolerability of a low dose of ARC-520 and its ability to reduce viral load and the key viral proteins, HBsAg and HBeAg, after intravenous administration in a chimpanzee with chronic hepatitis B infection. The animal being treated had exceptionally high titers of circulating HBV DNA and HBsAg that measured 1,000 to 10,000-fold higher than the average chronic hepatitis B patient. The HBV infection has been chronic for over thirty years and has persisted despite prior therapy with multiple anti-viral drugs and therapeutic vaccine exposures.
“Treating this animal represented a very difficult challenge,” said Dr. Chris Anzalone, President and CEO of Arrowhead. “It was the first large primate to be treated with ARC-520, and its viral and s-antigen loads were many orders of magnitude higher than what we expect to see in humans. Even with this high bar, we showed that a low dose was effective and extremely well tolerated. There is currently no way to reliably knock down key HBV antigens, thought to be critical to achieving a functional cure of the disease. Our data in multiple rodent models and now in a chimpanzee with chronic HBV infection suggest that ARC-520 may be able to provide this. We believe this is very important and positions us well for our planned clinical trials this year.”
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good p.m sir..di koh poh masyadong maintindihan..pero gus2ko poh tlga gumaling kah8 anong paraan gagawin koh poh,subrang gulong gulo na poh ako,may 3 anak poh ako ska asawa...sila poh dahilan kya gus2 ko poh gumaling,..sana poh matulungan mo poh ako..e2 poh tellphone no. ko 7109672..pwede din poh kay0 mag tx sa no. nayan..lagyan nyo lang poh 02tapos y0ng tellphone no. na parang 027109672
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sir pls..tulungan nyo poh ako
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ndi pa na release ung gamot, pero naniniwala ako malapit na lumabas ang lunas.Alagaan mo kalusugan mo at wag k mawalan pag asa
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09991727397 no ko yan sir ako din gusto magabroad single mom aq 3anak ko breadwinnir nanay ko may sis sa alakalakan papa ko lasenggo mga kptd ko wlng diskarte aq ng papakain .nahihirapan din po aq kc reactive din aq nahihiya aqng mlman ng mga ktrbho ko kc entertainer po aq gusto mabago buhay ng pamilya ko dhil nalugmok aq sa pgaasawa ko hadlang dn skn itong skit ko pero 5yrs kming nglivein ng aswa q d nmn xa nahawaan nakapgabroad nmn po.
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