Hepatitis B Community
F141L hbsag mutation promotes liver cancer
About This Community:

This forum is an un-mediated, patient-to-patient forum for questions and support regarding Hepatitis B. Topics in this forum include but are not limited to, Causes, Diagnosis, Family and Relationships, Living With Hepatitis B, Research Updates, Treatment, Success Stories, Support, Symptoms.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

F141L hbsag mutation promotes liver cancer

F141L Mutation in the Surface Antigen Be Trigger That Causes Liver Cancer
Researchers continue to search for the mutation or viral trigger that causes some people with hepatitis B to develop liver cancer. South Korean researchers reported in the January 2011 issue of the Journal of Virology that they may have found a mutation in the surface covering of the virus, called HBsAg, that may play a role in causing liver cancer.

They identified a mutation called F141L and looked for that in the surface antigen of 241 Korean patients with liver diseases at different stages.

They found F141L mutants were present in a significant number of liver cancer cases. The mutation was present in cancer cases more often than was cirrhosis—severe liver scarring—which is often considered a precursor to liver cancer.

“Our results suggest that (F141L) may contribute importantly to the [development] of liver cancer by inducing cell proliferation and transformation,” they wrote. They suggest that the F141L mutation could serve as a diagnostic test for liver cancer.
Related Discussions
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis B Community Resources
RSS Expert Activity
233488_tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488_tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543_tn?1371753642
Blank
TMJ/TMJ The Connection Between Teet...
Jan 27 by Hamidreza Nassery , DMD, FICOI, FAGDBlank
Top Hepatitis Answerers
Avatar_m_tn
Blank
stef2011
Italy
Avatar_m_tn
Blank
StephenCastlecrag
Australia
Avatar_m_tn
Blank
sorte
Other
Avatar_m_tn
Blank
hepbcurepls
los angeles, CA
Avatar_f_tn
Blank
Royal36
Avatar_m_tn
Blank
mike9111
MI