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F141L hbsag mutation promotes liver cancer
F141L Mutation in the Surface Antigen Be Trigger That Causes Liver Cancer
Researchers continue to search for the mutation or viral trigger that causes some people with hepatitis B to develop liver cancer. South Korean researchers reported in the January 2011 issue of the Journal of Virology that they may have found a mutation in the surface covering of the virus, called HBsAg, that may play a role in causing liver cancer.

They identified a mutation called F141L and looked for that in the surface antigen of 241 Korean patients with liver diseases at different stages.

They found F141L mutants were present in a significant number of liver cancer cases. The mutation was present in cancer cases more often than was cirrhosis—severe liver scarring—which is often considered a precursor to liver cancer.

“Our results suggest that (F141L) may contribute importantly to the [development] of liver cancer by inducing cell proliferation and transformation,” they wrote. They suggest that the F141L mutation could serve as a diagnostic test for liver cancer.
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