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2 months on entecavir and...
Hi Stef,  Aduiski,  Liverpatient,  Engr_delacruz and others.

I started taking entecavir 0.50mg, it's been two months now. Also taking vitamin D 3 supplement daily

Please help me with the following
I feel fatigued the next day of exercise (cycling),  I never had this problem before,  as stated earlier I did 100km endurance ride on 17th January without any problem. I was tested HBs Ag positive in blood test done in February first week,  later started with entecavir and it's been two months.

This fatigue symptom started 1 month after starting entecavir. What do I do now?  Is it the side effect of medication?

My SGPT is 57 and SGOT 53 now (they were 140 and 80 in the first test,  dropped to 69 and 65 in 10 days without medication)

Just for reference here are my first test results

HBsAg positive
HbeAg negative
HBcAB positive
Viral load 6250 iu /ml
HBsAg quantitative 1666.10 iu/ml
Sgpt 140
SGOT 80
Ultrasound normal Upper GI normal

Please guide

Thanks and Regards
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Avatar universal
Also taking vitamin D 3 supplement daily

is it 10.000iu daily?otherwise probably useless
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Follow your DNA at 3 and 6 months after starting Entecavir...
...at month 3 it should be bellow 100 or so for you...
...at month 6 it should be undetectable..


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@Stef yes taking 10000IU (it's a brand called Solgar it comes in soft gel capdules)

@Aduiski will check after 3 months
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Solgar is regarded as a good one...
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Thanks Aduiski
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Hi; I think the symptoms you are feeling are just temporary, and that they will disappear after your body adjusts to the medication. Just remember to lead a healthy lifestyle by eating varied and balanced diet as much as you can, exercise modestly, and, of course, limit alcohol and stop smoking if you used to smoke.
Reagarding vitamin D3 and other food supplements it is better to take a test of your levels before simply consuming these supplements. If your levels are within the recommended ones, then there is no need of exceeding the levels, possibly doing more harm than good.
Good luck with your treatment.
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Hi Liverpatient
Thanks for replying.  My vitamin D level was very very low. I do not drink alcohol and quit smoking 3 years ago.  I will keep my cycling to moderate level.
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Yesterday I did 30km cycling,  with two major climbs,  today morning woke fresh no muscular pain but experienced mental fatigue,  is something else going on here?  I do have anxiety problem.
While on the ride I do not feel tiredness.
Earlier I would be fresh and happy after cycle ride.
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If you have an anxiety problem then you might be just scaring yourself without a proper reason. Your symptoms might be anxiety-related...
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Hi Aduiski
I am also struggling with anxiety problem,  so what you say may be correct. Hope it is anxiety related only, I can then manage
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If you keep having muscle pains you can check "Lactate" (lactic acid) next time you do some blood test but you could expect it will return good...

You do have some issue with a blood pressure if I remember correctly? How is your glucose tolerance, eGFR and microalbumin (urine albumin)?
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Hi Aduiski
I will check lactate level.
I have hypertension and I take one tablet per day for that.
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When you check lactate you can also check eGFR and microalbumin. The standard way they test for eGFR is with creatinine, you could additionally check it with cystatin c.

In summarry:
- lactate (for muscle pains)
For kidneys you could check following if u wish and if you haven't tested them last year:
- eGFR
- cystatin c
- microalbumin (urine test)
- fasting glucose tolerance (need to abstain from eating 10-12 hours overnight before the test)



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Hi Aduiski
I will get those tests done

ONE UPDATE
I was diagnosed with hypertension 2 years ago and was on medication for the same. On medication also my BP uses to be 130/80. A week ago my BP was 100/70 and today it was 110/70, my medication strength was dropped from 40mg to 20mg a month ago and still BP is low.

Without medication my BP used used to be around 145/95

Why this drop?

Medication I am on
1. Entecavir 0.50mg
2. One Vance 20mg for BP
3. Clonotril 0.5 in the night for sleep and anxiety
4. Vitamin D 3 supplement 10000IU perday with lunch
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