I've browsed a bit more and you may be right, especially that study is interesting:
http://onlinelibrary.wiley.com/doi/10.1002/hep.21612/pdf
4% ? I saw much lower numbers like 1-2% in most of the resources.
of course
after many years for some unknown reason ?
one of the reasons is hbv mutates every time it replicates, these mutations are mistakes in replication that allow hbv to evade immune response and hide to immune system but it can also happen that a mutation exposes hbv to immune system or that mutation rate slows down after many years.this can be one of the reasons 4% of chronic hbv carriers clear every year
or if someone has spontaneous HBsAg seroclearence it means that his immune response to HBV started to work after many years for some unknown reason ?
you cannot find by commercial assays, you just try pegintf and see if there is hbsag lowering by 24weeks
how you can find out that there is any immune response ?
it can be of help only when an immune response exists already to boost it.
it works like this, you have no immune response, nothing works, pegintf, vit d and so on
you have a minimum of immune response, invisible to tests and not making any effect like hbsag/hbvdna lowering.but if you add to this pegintf, vit d and al supplements suggested the combination can amplify that immune response and you ll see an hbsag lowering
you can try it to improve response of peginterferon treatment, on its own it is useless on hbv, i already take most of that