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5 th inj pegasys and raised ALT
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5 th inj pegasys and raised ALT

hbsag + since 2005
anti hbs -
hbeag -
anti hbe +
alt and ast normal
hbv dna less than 116 copies / ml ( undetectable )

HBsAg quantitaive from 19 to 13.4 then 16 and now 20.23 over last one year
No treatment taken

Now have started with
-PEG interferon 180 mcg once weekly  
-Vit D

got 5 inj and now ALT 103 which had always been previously normal

Comments PLZ....
Good or bad sign ?
when to repeat HBsAg quantitative ?
Hopes ?
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Avatar_m_tn
the higher the alt the more infected cells killed the lower hbsag....so let's hope you can reach a good flare like 500-1000 but even flares 100-200 can clear hbsag when it is very very low, give it few months
38 Comments Post a Comment
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Avatar_m_tn
Your HBsAG was very low pre-IFN and looks like you might clear it with IFN.

Good luck.

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Avatar_m_tn
yea lets see what happens  
will repeat HBsAg quantitative after 8 inj
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Avatar_m_tn
No lift
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Avatar_m_tn
the higher the alt the more infected cells killed the lower hbsag....so let's hope you can reach a good flare like 500-1000 but even flares 100-200 can clear hbsag when it is very very low, give it few months
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Avatar_m_tn
What was your Vit D level pre-IFN and were you taking Vit D before IFN?

I am on my 10th week and only doing 90mcg. ALT flare as high as 131 but has come down to about 90.

My HBV was detected the same time as yours, which was 2005.

You should be happy that your HBsAg is so low and have you taken any anti-viral pre IFN?



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Avatar_m_tn
-Did not take antiviral before INF
-Did not check Vit D levels bec the test is costly and we all are defecient in Vit D
-Just started taking Vit D
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Avatar_m_tn
why only 90 mic
why not 180
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Avatar_m_tn
whats your HBsAg level before INF
when did u check it the last and what was that
i am thinking of repeating it after 8th inj ?
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Avatar_m_tn
How old are you? and what 's you hep B genotype?
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Avatar_m_tn
i am 32. and dont know the genotype
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Avatar_m_tn
Dr decide to reduce due to low blood count, particular WBC and neutrophils. The first 2 was 180mcg. The last eight 90mcg. ALT also flare to a similar numbers like yours. Before it was around 40 to 50.

Your e-antigen was always negative? But you are blessed with such a low HBsAg numbers. I have never had HBsAg done. I was born in Malaysia and I took ETV antiviral pre-IFN, where I converted e-antigen positive to negative.

I wish you have good result with IFN.
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Avatar_m_tn
yea my eAg had always been negative as i had HBeAg seroconversion with formation of Abs before i knew i have this condition.

6 inj  down and many more to go
will repeat HBsAg quantitative after 8th one  
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Avatar_m_tn
Please update us with the result as you receive them.

Any figures on WBC and neutrophils after the 4th injection? Also are you feeling tired most of the time? Just had my 11th shot. Upped it a bit to around 100mcg.

What's your height/weight and you are a male?

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Avatar_m_tn
Sure i ll update u with the results
WBC was 3 and neutrophils down down but within safe limit
PLT 159000

I feel so tired , so tired that i cant explain
always exhausted and fatigued
Energy has vanished

Appetite is good

I am male and 5 8 with 76 Kg

Good to hear from u that your dose has been increased

Why dont u check ur HBsAg quantitative
What about u any fatigue ?
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Avatar_m_tn
Yes, I feel fatigued and tired. Energy has vanish for me too. I upped the dose (slightly) myself since the neutrophils has increased.

I am male 5 7 and 63kg. Maybe because of that, I have to reduced dose due to my small frame. IFN is like chemo, causing tiredness and suck the energy out of your system.

I will check HbsAg when there is a measurement for it. I will let the Dr decide. I would have figured if they have the machine to measure it, they would do it.

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Avatar_m_tn
Its like a battle to continue working and the inj therapy.  
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Avatar_m_tn
7th inj down
Many more still to go
morale is high despite of the fatigue
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Avatar_m_tn
How do you keep your morale high ali?

Just did 12th shot yesterday (around 100mcg) and appointment with the Doc next week.

We need to support each other in this forum as we are all in this together.

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Avatar_m_tn
This week I will use my last 48th injection, I get tired fast and need to drink a lot of fluid to feel normal, sadly there is no HBsAg drop in my case.

Nevertheless this year went like split second for me. I think that is the worse thing about hepatitis, you loose your life thinking of the illness instead of enjoying it fully.
My advice is to focus on what you would normally do in your life. You never know when a random accident will get you too yet you don't worry about it. Same case here, fact you have hep doesn't mean you will die from it, its just another risk factor in your life.

Good luck with HBsAg kinetics!
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Avatar_m_tn
After 11 inj pegays
ALT 59
and HBsAg 18

No change in that
a lot of side effects of INF

Thinking of stopping INF
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Avatar_m_tn
What kind of sides? Can you please list them.
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Avatar_m_tn
i am having severe dryness of mouth
have to get up a few times in night to drink water
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Avatar_m_tn
Yeah, I had that.

Just put plenty of water near the bed but that's not the solution either. As you drink a lot, bathroom breaks are frequent.


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Avatar_m_tn
i feel tired, exhausted , headaches , backaches, neck pains , weakness, dry mouth , depressed, helpless
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Avatar_m_tn
unfortunately that s the effect of immune activation with too much inflammation, a high vitamin d level over 100ng/ml should be able to lessen the inflammation effect and obtain even faster results
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Avatar_m_tn
Yeah try and get used to it. Organism will even up after 2-3 months and you will feel better.

You are now officially married to a bottle of water so keep that in mind you need to be with one all the time. Dehydration is a real pain, it comes down that you need to keep drinking all the time to avoid feeling drained out.


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Avatar_m_tn
Thanks a lot guys. your comments are a real help
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Avatar_m_tn
Hey buddy how are u ?
any sides these days ?
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Avatar_m_tn
12 inj down
12 more to go

Half the journey is complete
But its tough
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Avatar_m_tn
Just did the 16th shot. Bad injection. The syringe has blood inside after the injection.

Sides that are noticeable are fatigue and tiredness.

How are you holding up? Is your treatment only 24 weeks? Mine is 1 year.

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Avatar_m_tn
dear mustthinkpositive
tiredness and fatigue
but dryness of mouth is better
Had dryness of mouth just for a day, 2 days after the inj

Plan is of 06 months and evaluate

See what happens ?
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Avatar_m_tn
where you have done your hbsag quantitative test ? are you from Pakistan ?
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Avatar_m_tn
yes
chaughtai lahore labs
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Avatar_m_tn
Yep, these are the common sides of IFN. It's like chemo....***** the drain of your energy levels.
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Avatar_m_tn
Unfortunately no labs is doing hbsag quantitative test here in Karachi. :(
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Avatar_m_tn
Kindly check your inbox.
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Avatar_m_tn
kindly check ur inbox
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Avatar_m_tn
please, how far with that treatment
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