A 3 month follow up results since I got diagnosed chronic hep b:

[itac]

Hi guys,

Hope you are all doing well. Been pretty busy with life and work, and didn't really have time to surf here, sometimes it feels good to forget about having "this", and focus on other things in your life.

Anyways, I posted here about 3 months ago, when I got diagnosed, these were the initial full results: http://www.medhelp.org/posts/Hepatitis-B/Finally-got-the-first-full-picture-of-my-results-Should-I-start-treatment/show/2607632#post_12690891

Since it's all new, and I'm trying to understand how this condition affects my body, I decided to get tested every 3 months on the first year, and also really see that I'm chronic, if I test positive beyond 6 months mark. I also had vitamin d insufficiency, although I've been taking 1000ui vitamin d3 daily doses. I increased the dose to 2000ui a day.

Note: I'm genotype D e negative (with precore mutations A1762T/G1764A), 27 years old, have good fibroscan/ultrasound results for my liver.

Here are the results (May -> August):

NOW: ast 17 (ref range: 10-40 u/l)
NOW: alt 22 (ref range: 9-46 u/l)
WAS: vit d, 25-oh, total: 28 (ref range: 30-100 ng/ml) NOW: total: 37 (ref range: 30-100 ng/ml)
WAS: pth intact 35 (ref range: 14-64 pg/ml) NOW: 36 (ref range: 14-64 pg/ml)
WAS: hbv dna 1311 ui/ml NOW: 865 ui/ml

It seems like the hbv dna got reduced, and the vitamin d went higher after increasing the dose...
I don't know how is the hbsag quant, since I'm in the US and it's not provided here. Is there a way to guesstimate what the hbsag quantity is like based on these results? Also, I'm not taking any medications as I'm not a candidate.
What would you suggest to do next in order to seroconvert? Do you think I got potential or I'm stuck with this virus because of the mutations?

Thanks!

[flyinsky]

Sorry for written mistakes.I mean no less no more

[flyinsky]

http://www.medicaldaily.com/taking-too-many-dietary-supplements-may-increase-risk-some-cancers-330020

Take a look on This.
M'y point of view is giving our body what realt needs not mess not more and each one is free of doses he takes

[Royal36]

The topic is VIt D.

[sorte]

"too much supplements" is so general statement, we need to say which supplements and when it's too much

[flyinsky]

Also recently I read that too much supplement cause cancer.si moderation in taking it if necessary

[flyinsky]

Personally for vit d I read lot about it is better for all persons hbvesrs or not to be in the normal range.for me I verify always before taking it by test if I have a luck I take ample if not I will not and my level niw is in the normal range.and any luck of any vitamins should have an impact on our health .

[sorte]

- there are the studies which found that low d3 level equals worse/slower peginf response for hcv
- I've also posted here, few times, a link to the study which connects normal d3 level with seroconversions in assymptomatic carriers.
- there is a study which found that low d3 equals higher hbv dna. Ok, let's be honest, we don't know what is a cause and what is sympthom, but there's a connection proven.

[itac]

"Itac no one is forcing u to take anything.. The way u r asking proof as if u think some miracle cure is present here. Vit d has certainly some benefit against hbv and their are a few more but none is proven to clear hbv completely from body. It's luck some ppl have cleared on these some not. So it's really like buying a lottery n c ur fate. It's ur wish. "

Jatashankar, I'm not asking for a proof of a miracle cure... but it seems like there are lots of claims that stef makes that have no logical scientific basis... And some people seem to follow his advice blindly, without thinking for themselves... I guess each for it's own...

It just... what different does it makes if my vit d is in the max or in the middle, if the final result seroconversion won't occur in either case.... it's like risking your body with stuff doesn't even help you... as long as your vit d is in the norm range, I don't see the hype to top it... not one has seroconverted just solely because of that... maybe good vit d level is a pre requirement to seroconvert, but it's not enough by itself... as long as we don't have the part that really helps to seroconvert.

[Jatashankar]

Itac no one is forcing u to take anything.. The way u r asking proof as if u think some miracle cure is present here. Vit d has certainly some benefit against hbv and their are a few more but none is proven to clear hbv completely from body. It's luck some ppl have cleared on these some not. So it's really like buying a lottery n c ur fate. It's ur wish.

[itac]

"vit d is a must on peg, low levels make no response to peg"

Is there a proof that vit d is a must on peg?

Plus I'm not taking any medications, so why I need to max my vit d?

It's like telling someone to a buy a lottery ticket, saying that he might win...

[stef2011]

vit d is a must on peg, low levels make no response to peg

[stef2011]

people who seroconverted here was on peg and vit d some combo with nucs or gcmaf and one was on gcmaf mono.seroconversion rates here are extremely higher than trials

[Elijah256]

I don't think many people did. I admit I don't get the flu at these dosage. Most people I see that seroconverted on here was nowhere near 80-150ng/ml

[itac]

"i cant go back on all the studies of vit d posted here in the last 3 years, you have to search them yourselves, the main studies are:
hbvdna and vit d levels inverse correlation
high percentage of hbsag seroconvertion on normal vit d carriers
most studies on cancer prevention and immune system boost are on levels 80-100ng/ml and anyway it makes no sense to keep levels less than max normal levels (which are between 100 and 150ng/ml according to hospitals/research centers)

studies are gathered/linked on this website, vitamindwiki.com

most studies are not free on the links, only abstracts are free"

Question: How many in this forum, who followed this suggestion of maxing vit d and minimizing pth seroconverted? Give the name of these posters...

[stef2011]

i cant go back on all the studies of vit d posted here in the last 3 years, you have to search them yourselves, the main studies are:
hbvdna and vit d levels inverse correlation
high percentage of hbsag seroconvertion on normal vit d carriers
most studies on cancer prevention and immune system boost are on levels 80-100ng/ml and anyway it makes no sense to keep levels less than max normal levels (which are between 100 and 150ng/ml according to hospitals/research centers)

studies are gathered/linked on this website, vitamindwiki.com

most studies are not free on the links, only abstracts are free

[itac]

"for hbvers 10.000iu is the min dose daily, then after 4-5 months you can see if a lower dose like 5000iu is ok.vit k2 mk7 100mcg would be best and also some vit a from cod liver oil and some magnesium.life extension has a vit d3 with 5000iu and vit k2

range needed is vitd25oh 100ng/ml and intact pth lowest of norm, in your lab 14pg/ml "

Based on what you say that you need you need max your vitamin D level and minimize the pth level? Is there a scientific research to backup your suggestions? How is bringing those to their respective min/max values is going to help eradicate the virus if at all? If it doesn't then what's the point doing so? And yes, I know you are going to say it has lots of health benefits... But to me it sounds like your own suggestion, not a backed up scientific advise...

[itac]

"I know lal path has collection centres in South Asian countries and ppl from Europe and Middle East even send their blood samples to India. Regarding US m not very sure but u shall contact lal path and FedEx or any courier regarding this. And not just India u shall contact and country close by which does so.
Serum quality do not deter for a long time if properly kept at moderate temperatures. I don't know if u can ask a nurse or medical assistant to draw ur blood on request in US or not.
Acc to treatment guidelines u must have high alt Atleast 2times normal and hbv dna more than 2000 for hbeag negatives to start IFN.
U don't meet these criteria."

Thanks, I will try to contact them to see if I can get the hbsag quantity done... If I turn out to have a low hbsag quantity, can I be a good candidate for IFN then?

[Jatashankar]

Ohh Steff do hbsag values deteriorates on shipping?

[stef2011]

for hbvers 10.000iu is the min dose daily, then after 4-5 months you can see if a lower dose like 5000iu is ok.vit k2 mk7 100mcg would be best and also some vit a from cod liver oil and some magnesium.life extension has a vit d3 with 5000iu and vit k2

range needed is vitd25oh 100ng/ml and intact pth lowest of norm, in your lab 14pg/ml

unfortunately you can follow only hbvdna, i d ship samples for hbsag to india or europe

[Jatashankar]

I know lal path has collection centres in South Asian countries and ppl from Europe and Middle East even send their blood samples to India. Regarding US m not very sure but u shall contact lal path and FedEx or any courier regarding this. And not just India u shall contact and country close by which does so.
Serum quality do not deter for a long time if properly kept at moderate temperatures. I don't know if u can ask a nurse or medical assistant to draw ur blood on request in US or not.
Acc to treatment guidelines u must have high alt Atleast 2times normal and hbv dna more than 2000 for hbeag negatives to start IFN.
U don't meet these criteria.

[itac]

"Y don't u ship ur blood sample to India for hbsag quant, FedEx does the shipping work. Contact drlalpathlabs for this. Seroconversion today is only possible through interferon, but u don't seem to be a candidate for that "

Do you know people who live in the US and shipped their blood sample to India? It sounds like a very long time to send the blood, which might get worst quality on it's way to India? Also, do they have a blood station in US that actually withdraw the blood? How can you tell they give an accurate result?

Also, why you don't think I'm a candidate for interferon treatment?

[Jatashankar]

Y don't u ship ur blood sample to India for hbsag quant, FedEx does the shipping work. Contact drlalpathlabs for this. Seroconversion today is only possible through interferon, but u don't seem to be a candidate for that