A Mathematical Model for Combination Therapy Peginterferon+Lam

http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?arnumber=5515855

Based on the clinical date of the Peginterferon Alfa-2a plus Lamivudine (combination therapy) for HBeAg-Positive chronic hepatitis B patients, this paper sets up a mathematical model
In particularly, we can account for the phenomenon of HBV DNA load returned after stopping the therapy. Numerical simulations show that if we proceed with the treatment 6.8 years, the HBV virus will be completely eliminate in infected heptocytes.

very good to know but:
entecavir or tenofovir are more potent and maybe faster than lam
nitazoxanide might improve and fasten peinterferon response
7 years of continuous interferon are not easy although trials are reached already 5-6years, i'd wait interferon lambda for such a long interferon tx which is only mild sides

in any case this will be the future combo both to eradicate hbv and avoid any resistance (even lam has zero resistance if comboed with interferon)