Hepatitis B Community
A Mathematical Model for Combination Therapy Peginterferon+Lam
About This Community:

This forum is an un-mediated, patient-to-patient forum for questions and support regarding Hepatitis B. Topics in this forum include but are not limited to, Causes, Diagnosis, Family and Relationships, Living With Hepatitis B, Research Updates, Treatment, Success Stories, Support, Symptoms.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

A Mathematical Model for Combination Therapy Peginterferon+Lam

http://ieeexplore.ieee.org/xpl/freeabs_all.jsp?arnumber=5515855

Based on the clinical date of the Peginterferon Alfa-2a plus Lamivudine (combination therapy) for HBeAg-Positive chronic hepatitis B patients, this paper sets up a mathematical model
In particularly, we can account for the phenomenon of HBV DNA load returned after stopping the therapy. Numerical simulations show that if we proceed with the treatment 6.8 years, the HBV virus will be completely eliminate in infected heptocytes.

very good to know but:
entecavir or tenofovir are more potent and maybe faster than lam
nitazoxanide might improve and fasten peinterferon response
7 years of continuous interferon are not easy although trials are reached already 5-6years, i'd wait interferon lambda for such a long interferon tx which is only mild sides

in any case this will be the future combo both to eradicate hbv and avoid any resistance (even lam has zero resistance if comboed with interferon)
Related Discussions
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis B Community Resources
RSS Expert Activity
469720_tn?1388149949
Blank
Abdominal Aortic Aneurysm-treatable... Blank
Oct 04 by Lee Kirksey, MDBlank
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
Top Hepatitis Answerers
Avatar_m_tn
Blank
stef2011
Italy
Avatar_m_tn
Blank
StephenCastlecrag
Australia
9624973_tn?1413019730
Blank
melcul
United Kingdom
Avatar_m_tn
Blank
mer971
Avatar_m_tn
Blank
mike9111
MI
1084115_tn?1385232189
Blank
rexx73
Switzerland