Hepatitis B Community
ARC 520
About This Community:

This forum is an un-mediated, patient-to-patient forum for questions and support regarding Hepatitis B. Topics in this forum include but are not limited to, Causes, Diagnosis, Family and Relationships, Living With Hepatitis B, Research Updates, Treatment, Success Stories, Support, Symptoms.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

ARC 520

http://www.arrowheadresearch.com/press-releases/arrowhead-rnai-candidate-arc-520-induces-greater-90-reduction-circulating-hbv-dna

PASADENA, Calif. — March 14, 2013 — Arrowhead Research Corporation (NASDAQ: ARWR), a targeted therapeutics company, today announced that a study of its RNAi-based candidate ARC-520 in a chimpanzee chronically infected with the human hepatitis B virus (HBV) supports findings from rodent models indicating that it can knock down HBV DNA and key viral antigens. Dr. Robert Lanford and his team at the Texas Biomedical Research Institute are conducting the study. The chimpanzee being treated has had chronic HBV for over 30 years, has high viral-titer and antigenemia, and nearly 100% of hepatocytes stain positive for HBV. Studies are ongoing and additional data will be discussed when the company hosts an analyst and investor event on March 25, and at upcoming scientific conferences.
It’s encouraging to see data from our preclinical rodent models confirmed in a true primate disease setting,” said Bruce Given, MD, Arrowhead’s COO and Head of R&D. “There are very few high primates that develop chronic HBV. We understand these studies to be useful predictors of the response we might expect in human patients as we approach clinical trials later this year.”
Investors and analysts may access the live presentation on March 25 on the Arrowhead Research website at www.arrowheadresearch.com or by calling 1.888.771.4371 (US toll free) or 1.847.585.4405 (US toll) and using the confirmation number: 34474854.  The webcast will also be available for 90 days following the event.
7 Comments Post a Comment
Blank
Avatar f tn
Interesting push.

Blank
Avatar m tn
Now on chimpanzee .. later on human .. did arc520 readicate the antigens totally?
Blank
4973930 tn?1361793338
They have come up with (Roche) a new Test liver it was cloned I think. It is now being used to test different drugs for Hep C. Just read the article
Blank
Avatar m tn
but it says hbvdna which is useless to clear hbv, if they dont report hbsag i think it is another useless drug just to make money
Blank
Avatar m tn
"and key viral antigens" - which is referring to HBsAg and HBcAg
Blank
Avatar m tn
It will be fascinating to see the suppression data on this longterm infected chimp. Hopefully they have injected more than once.
Blank
Avatar m tn

I am Ravi 33 years old, chronic Hep B (e-antigen negative) positive for last 5 years,

Could you please let me know that can i be a voluntary for yours trails in Arrowhead RNAi (ARC-520) treatment?

I saw many online Presentation about Arrowhead RNAi (ARC-520) it is really very grate news and this treatment looking promising also.
Please let me know whom need contact and how to approach to be voluntary for this treatment.  
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis B Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
05/15 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1463449675
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Hepatitis Answerers
Avatar universal
Blank
Italy
Avatar universal
Blank
Australia
Avatar universal
Blank
Poland
Avatar universal
Blank
Other
Avatar universal
Blank
Bangalore, India
Avatar universal
Blank