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ARC 520
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ARC 520

http://www.arrowheadresearch.com/press-releases/arrowhead-rnai-candidate-arc-520-induces-greater-90-reduction-circulating-hbv-dna

PASADENA, Calif. — March 14, 2013 — Arrowhead Research Corporation (NASDAQ: ARWR), a targeted therapeutics company, today announced that a study of its RNAi-based candidate ARC-520 in a chimpanzee chronically infected with the human hepatitis B virus (HBV) supports findings from rodent models indicating that it can knock down HBV DNA and key viral antigens. Dr. Robert Lanford and his team at the Texas Biomedical Research Institute are conducting the study. The chimpanzee being treated has had chronic HBV for over 30 years, has high viral-titer and antigenemia, and nearly 100% of hepatocytes stain positive for HBV. Studies are ongoing and additional data will be discussed when the company hosts an analyst and investor event on March 25, and at upcoming scientific conferences.
It’s encouraging to see data from our preclinical rodent models confirmed in a true primate disease setting,” said Bruce Given, MD, Arrowhead’s COO and Head of R&D. “There are very few high primates that develop chronic HBV. We understand these studies to be useful predictors of the response we might expect in human patients as we approach clinical trials later this year.”
Investors and analysts may access the live presentation on March 25 on the Arrowhead Research website at www.arrowheadresearch.com or by calling 1.888.771.4371 (US toll free) or 1.847.585.4405 (US toll) and using the confirmation number: 34474854.  The webcast will also be available for 90 days following the event.
6 Comments Post a Comment
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Avatar_f_tn
Interesting push.

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Avatar_m_tn
Now on chimpanzee .. later on human .. did arc520 readicate the antigens totally?
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4973930_tn?1361793338
They have come up with (Roche) a new Test liver it was cloned I think. It is now being used to test different drugs for Hep C. Just read the article
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Avatar_m_tn
but it says hbvdna which is useless to clear hbv, if they dont report hbsag i think it is another useless drug just to make money
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Avatar_m_tn
"and key viral antigens" - which is referring to HBsAg and HBcAg
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Avatar_m_tn
It will be fascinating to see the suppression data on this longterm infected chimp. Hopefully they have injected more than once.
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