After 16 week with Interferron + Simvastatin

[Otan]

Took 1st dose on 21 Oct 2011 and on 11 Jan 2012 HBV DNA not detected.  
Below is the lab history,                          

Date            13/9  20/10  21/10  11/11  16/11  9/12  15/12  6/1/12  11//1/12
                                   1st dose                                   12th dose
SGOT                    35*                          49*             63*                  67*
SGPT                    63*                          78*             89*                  90*
HBsAg     366.44  255.68                                                              176.4*
HBV DNA2.54x10^5                                                                   no detect

Result on week# 16

SGOT  86
SGPT  130
HBsAg  10.49

When HBsAg became zero, then what to do? Is that time to stimulate Anti-HBs?

[Otan]

Steff,
I think I expose to sun a lot.
I live in thropic city Jakarta, secondly I dont work in office but field. Often I work under the sun from 7 - 12 and 13 - 17 daily.

Once I asked for vitd25oh check as you suggested but, it cost like around 200 usd. So Did not check.

[stef2011]

i dont think the issue is hbv but you know nobody can tell for sure...i d work on vit d first, if you are not exposed to sun all day and equatorial country your levels should be low and you can start increasing them by long hours sun exposure or supplements with combined vit k2.
dose must be at least 5000iu daily and vit k2 100 or 400mcg daily.high dose k2 can also be found on fermented vegetables or some european cheese

i d check vitd25oh levels only after 5-6 months supplements, it is strange the test is expensive here in europe cost is from 16 to 30€

before taking the vaccine it is best to increase d levels to 80-90ng/ml and then see hbsab levels and ast-alt.i dont know if you seen latest study:
vitamin d correlates to hbvdna and highest d levels are found in low/und hbvdna

normal vit d levels are found on hbv carriers clearing hbsag off therapy

[Otan]

Steff,
Yes, I did ultrasound at Gleaneagles- Penang Malaysia on 3rd Apr 2012 and were AST-93  ALT-153, HBV DNA-und, HBSAg-6.9 index (reactive), HBSAb-1.3 mIU/ml
Ultrasound result;
The liver is normal in size and diffusely increases in echogenicity. No focal liver lesion. No dilated intrahepatic duct/CBD.
The gallbladder appear normal. No gallstone.
The head of pancreas, spleen, and both kidney are normal. RK=10.9 cm; LK=11.1cm in bipolar length. No hydronephrosis. No renal calculi. No ascites. Normal abdominal aorta.

Impression:
Fatty Liver

For vitd25oh, I did not check. I checked the cost was expensive

For HBSAG type, I dont  know what my type is
I may try other type of vaccine.

[stef2011]

did you check ultrasound so that we know the abnormal ast-alt is due to fatty liver and not remaining cccdna in the liver?

do you also have your vitamind25oh to optimum levels?vitd25oh>50ng/ml should help control and resolve fatty liver is present

there is also an hbv vaccine produced in israel since few years, it has all hbsag types (and much more potent than normal hbv vaccine which has only one type of hbsag).we open a thread about it, this is also distributed in some asian countries i believe

[Otan]

Cyrus,
Sorry Cyrus to reply you late, I was at Rig with less facility recently.

My last update,

6/3/13 SGOT-26  SGPT-37; HBV DNA-undtc; HBsAg Qty- <0.05 iu/mL; HBsAb- 26.12; HBeAg- Non React; Anti HBe- React

22/4/13 SGOT-27  SGPT-46; HBsAg- Non React; HBsAb- 20.4

My recent update,

24/5/13  SGOT-27  SGPT-35; HBsAg- Non React; HBsAb- 15.34
12/8/13  SGOT---  SGPT---   ; HBsAg- Non React; HBsAb- 23.32

With me, I feel fit, normal except my finger joint.
I do my work fisically with my hand, lifting load.
Before interferron, if I worked over with my hand (finger) I felt cramp and will recover after a week rest.
But now, the cramp gone after the rest but left the finger joint like stiff.
But it does not effect my work too much.

I am welcome for any questions regarding my theraphy.
Sorry again for reply late.

[cyrus131]

Dear Otan,

How are you recently?  Grateful if you could kindly share your updated status.  Thanks.

Regards,

Cyrus