Alinia

[toby101259]

I just started Viread.  I would like to try Alinia as well since I've heard some good things about it.  It seems that I need a prescription for it.  I don't have a whole lot of knowledge about Hep B and I don't think that I can argue for it and I don't think that my doctor would go for it.  He pretty much said I should start with tenefovir.  Is there an online place where I can purchase it?  Does it have any side effects and would it be okay since I'm starting Viread?  Thanks for any information.

[stef2011]

http://ihlpress.com/pdf%20files/hepdart09_presentations/emergence_prevention_vr/1_Lok.pdf

[stef2011]

you can see the sum of latest research in the links below, the studies of locarnini on hbv resistant mutations are the most useful for you but of course you must absolutely know all the mutations by the resistant mutations tests

https://docs.google.com/fileview?id=0B_yFgxI8KNcRMmI5YzdjYzMtMGZjNy00MGQyLWE5MWEtYTFlYjRiMmQxNTEz&hl=en

https://docs.google.com/fileview?id=0B_yFgxI8KNcRY2MzMjEzMTMtODU3ZC00ODg3LWE5ZTktYzc0NDExYzI1ZmQw&hl=en

https://docs.google.com/fileview?id=0B_yFgxI8KNcRNGVjNzI3ZTMtNTJkZS00MjNmLWE4MWQtMTZlNzZmYWY2ZDlh&hl=en

https://docs.google.com/fileview?id=0B_yFgxI8KNcRZjQyZTBjZWItY2FjZS00NDIxLWJhNDAtODMzZTkyM2Q0NDJl&hl=en

https://docs.google.com/fileview?id=0B_yFgxI8KNcRZTExZjE2MGYtZWY4ZC00ZDA4LWEwNGMtMDlkNWVhMTkzZDhl&hl=en

https://docs.google.com/fileview?id=0B_yFgxI8KNcRNTZlYzBmOTAtM2RkYi00ZjYxLTkzZDgtNGY5ZDdmMzEzOGVi&hl=en

[stef2011]

anyway ntz is active on hbsag, hbcag and hbeag not directly on hbvdna, so response on hbvdna might take 6-12 months if any response is achieved
so i think that a combo makes much more sense since all drugs are active on hbvdna but not hbsag, so in a combo you get both hbsag decease and hbvdna decrease fast

[stef2011]

So Alinia does not work for those who have achieved HBV DNA undetectable?  

we don t know for sure because our group is small but those hbe positive and hbvdna undetactable under nucs (tnf or etv) have very little hbsag decrease.
there are also several studies who say that nucs suprress immune system hbcab antibodies when they make hbvdna und and also interferon works less if strted with hbvdna und.so better start it first as they do for hcv and if possible 4 weeks monotherapy then add the other drug.
i started when my hbvdna was 135iu/ml on 4 moths entecavir monotherapy and i am hbe negative, i had hbsag reduction of more than 50% in 4 weeks,

the larger human trial made for hcv have also found that 4 weeks on ntz before interferon or other drugs give much more results

It is used only for those who start treatment?
what do you mean exactly?many in our group are on ntz monotherapy, they will add a second drug after 6-12 months

the best results until now are on the same combo used on hcv: 4 weeks alinia mono and then alinia+ntz, this is really a bomb both for hbe pos or hbe neg

[chanthou]

Hi Stefano,

So Alinia does not work for those who have achieved HBV DNA undetectable?  It is used only for those who start treatment? Thanks.

[stef2011]

I can't remember the exact ALT and viral load off the top of my head, but something like:
ALT:  124
HBV dna:  about 500,000

hbvdna is like mine baseline, not high viral load, medium, according to the number of infected liver cells and cytoxic immune response it will take 3-9 months to hbvdna und

alt 124, not high, if you have a chance to check the quantity of hbcab Igm because if higher than 0.02 s/co you might have very good results by therapy because your immune system is active.that's the best moment to start therapy, usually high alt flares like 500-1000 correlates with hbcab igm>0.02s/co

Since I just started Viread, I need to go back in a month to check status of alt & hbv dna.  I will ask the doctor about Alinia then.  If he won't prescribe, I'll try another route such as online pharmacy.  I looked at the link that you gave me and I can't figure out how the online pharmacy actually works.  

i suggest not to waste time since online order takes 21days or more for delivery if you get hbvdna und/very low by a month (can be possible) alinia will work much less, actually alinia should be started first.since off label it is very difficult your doc will prescribe but if he is updated and knows how drug is safe he might

Also, can you guys help me with how to go about asking my doctor to prescribe alinia to me?  I'm not really sure how to defend it.  I don't know a whole lot and I'm not sure if he does or not.  I ask this because I asked the doctor about interferon when we first met and he said that it isn't really used for chronic hbv patients and usually doesn't work, so I'm not sure how positive he will be with alinia.  Thanks for any input.

very bad answer, actually interferon is the best first line drug and it is the only  drug to tell you in 12-24weeks if you are among those responders who clears hbsag.it works only on about 50% patients but if it works it is the only one to clear hbv so it is the best first try.he will not prescribe alinia, looks like one with his own ideas and no way to talk about it

Also, when tested for hbsag, it just came back with "positive."  Do I need to ask for a different test to get the actual numbers?
yes if doctor or hospital is updated you should have the quantity test, first to know if you are among interferon responders clearing hbv (hbsag<1500iu/ml), second it is needed to know if therapy is working and also to know if alinia will work, viread lowers hbsag 0,5-1log per year on about 19% patients

i don t like the doctor at all and the hospital as well but i did the same mistakes as you when i started therapy (nov 2009) but also started to look for the best centers and researchers in italy and also suggested by my doctor went to the best (march 2010).
researcher said going to a normal hospital is like going to fast food instead of having a chef cooking for you only.a normal hospital will not help you much clear hbv but just follow guidelines without personalized therapy according to your baseline status and therapy response

there is one bad thing about US, medicine is more business than cure, infact interferon is not used much and hbsag quantification is very difficult to find, on the contrary they just give Nucs to anyone which have the maximum profits (10-15 years or life threapy) but they don t clear hbv and are not the best therapy for all

[toby101259]

I can't remember the exact ALT and viral load off the top of my head, but something like:
ALT:  124
HBV dna:  about 500,000

I don't necessarily trust my complete health to doctors only, so I am glad for everyone's input.  I would like to learn more and take control of what I do for my health.

Since I just started Viread, I need to go back in a month to check status of alt & hbv dna.  I will ask the doctor about Alinia then.  If he won't prescribe, I'll try another route such as online pharmacy.  I looked at the link that you gave me and I can't figure out how the online pharmacy actually works.  

Also, can you guys help me with how to go about asking my doctor to prescribe alinia to me?  I'm not really sure how to defend it.  I don't know a whole lot and I'm not sure if he does or not.  I ask this because I asked the doctor about interferon when we first met and he said that it isn't really used for chronic hbv patients and usually doesn't work, so I'm not sure how positive he will be with alinia.  Thanks for any input.

Also, when tested for hbsag, it just came back with "positive."  Do I need to ask for a different test to get the actual numbers?

Thanks for everyone's patience.  I am trying to cope with all this and learn as much as I can as all this is new to me.

[stef2011]

you can order them safely at prescriptionrx since i have checked purity of drug and nizonide500 is ntz at 99,655% purity, so it is safe to order there

how much is your high alt and high viral load?

from what we have observed until now ntz works on antigens interfering with RNA transcription inside the infected liver cell (do not affect healthy cells) but have no direct activity on hbvdna, so the best candidates are hbeag negative/hbeab positive with low hbsag.
hbsag is usually 2-3 log (100-5000iu/ml) on hbe negative but rarely it is 4-5logs even on hbe negative (10000-50000iu/ml), in case hbsag is higher than 5000iu/ml it will take long time before we see hbvdna lowering on monotherapy, probably 6-12months.
So it is important to have a test to see hbsag quantity and check if it lowers.

as to hbvdna and alt it is better to combo with tenofovir (viread) or entecavir which are very active only on hbvdna, so by this combo most of us should get hbvdna und, normal alt, and fast lowering of hbsag and hpoefully get it negative by 1-2 years like in first human trials

[kenya3510]

stefano is right, I live in florida and got it from CVS pharm but you need to tell your doctor to prescribe it for you, mine did with no problem. I take viread, once a day (at night) alinia, twice a day for the last 3 weeks and no side at all. good luck!!!

[toby101259]

Thanks for the info Stefano.  Looks like I may need prescription for them.  I'm in the states, but not near Mexico.  I really do wish I could try it.  I have high viral load and ALT and AST right now.  I am also hbe negative/hbeab positive, so it sounds like I might be a good candidate.  I will try to see what I can do.

[stef2011]

of course share you experience, and results on community

we have a study report on a patient with adv resistance and high hbvdna load, he made alinia+adv combo for 2 years, got hbe negative, hbvdna und and normal alt after 1 year and hbsag egative by 2 years.adv is almost the same chemical ingredient of tnf but tnf is much more potent and less toxic

[stef2011]

if you are in florida a member of our community who just started viread got presciption for it and bought it from lupin offcial pharmacy distributor, if you are in florida i might try contact this member if he/she doesn't read this post

this is the list of ditrib in US with prescription
http://www.lupinpharmaceuticals.com/adrsub.htm#product_t

you might also buy daxon in mexico if you are close there or from

or buy it where i buy mine, prescription is needed but since this drug has no sides they might sell it anyway:

https://www.progressiverx.com/store/search.php?mode=search&page=1&keep_https=yes

it is very important that you start alinia before hbvdna is und and amximum result is on hbe negative/hbeab positive

you should also find a lab to check hbsag quantity, abbott hbsag quantificationin iu/ml is the best, but if you have a strong response you might also monitor by hbsag test with s/n unit

take it only with food 1or 2 pills at breakfast and one or two at dinner, only side mild diarrea that resolves spontaneously