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Any one know what this NVR 3-778 is?
Potential first-in-class treatment is well-tolerated in patients with chronic hepatitis B https://www.sciencedaily.com/releases/2016/04/160416090009.htm
thank you!
i found in their website that it's suppose to also provide greater and faster suppression of cccDNA and possibly also reduce HBsAg levels
https://noviratherapeutics.com/pipeline/nvr3-778/
i found in their website that it's suppose to also provide greater and faster suppression of cccDNA and possibly also reduce HBsAg levels
https://noviratherapeutics.com/pipeline/nvr3-778/
NVR 3-778 is a capsid formation inhibitor. The hbv core protein produced during hbv replication is used to a form a capsid, inside the capsid containing the pgrna, reverse transcription takes place. NVR 3-778 disrupts the formation of the capsid, without a properly formed capsid, new virion cannot be replicated. TDF/ETV inhibit reverse-transcription taking place inside the capsid. So all of them target the replication process. If successful, it will lead to reduction of hbvdna in the serum.
Just my layperson understanding.
Just my layperson understanding.
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