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Baraclude (entecavire) use during pregnancy
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Baraclude (entecavire) use during pregnancy

Hello, I just started taking Baraclude (entecavir)  0.5mg for Hep B  two weeks ago. I went through a year of interferon and did not help at all.  I wanted to know if anyone has been pregnant while on this medication.  I can't really find any info about the side effects this drug has on a baby.  My doctor says it should not be a problem if I was to get pregnant.  I read that Baraclude is classified as a category C drug by the FDA.  I desperately want to have a baby since I am almost 36 years old, but not at the cost of bringing a child into this world and having them suffer all their life if this drug were to have side effects on the baby.  It's not fair to do that to an innocent baby.  Please help. If anyone can share their experience or help me with some information.  Thank you.
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Avatar_m_tn
not allowed on pregnancy, only tenofovir (viread) is good on preganancy, no resistance, most potent on hbv and even much cheaper than entecavir, it is also about to lose patent so it may become as cheap as indian generics which are as low as 21usd per month

peginterferon must be used after 3-5 years on tenofovir to work and clear hbv, hbsag is cleared in 50%
peginterferon monotherapy can work only for very low hbsag and very low hbvdna otherwise it is useless to try just 7% hbsag clearance

you also must supplement vitamin d3 and make serum levels vitd25oh 90-100ng/ml, this is a must for all hbv carriers on or off therapy, about 10.000iu of d3 daily needed
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Avatar_m_tn
There are very good studies of antivirals during pregnancy. Experts have very good consensus in this area. Please read the following article:

http://www.medscape.com/viewarticle/807416_2

Currently, antiviral treatment is recommended in the third trimester for women with very high viral load to further reduce the risk of vertical transmission. Tenofovir has been shown in some studies to be safe to be taken throughout the whole pregnancy.
Please read the article carefully and discuss your situation with both your liver specialist and gynaecologist/obstetrician.
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