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Can lamivudine completely cure chronic Hepatitis B?
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Can lamivudine completely cure chronic Hepatitis B?

I am a 26 year old male having hbsag and hbeag=+ve,hbv dna =1070 iu/ml(Taqman) but my LFT results are normal(sgpt=37,sgot=33).My doctor has asked me to take lamivudine 100 mg for 6 months or until hbv dna becomes -ve.My mom is taking lamivudine for the last 7 months after her hbv dna crossed 8 lacs iu/ml.Probably I have been infected from my birth.Is it possible for both of us to completely cure Hep. B after taking lamivudine.
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Avatar_m_tn
no antiviral can cure hbv infection they can only lower virus replication and liver damage

lamivudine is out of guideline since a longtime because it makes extremely dangerous virus mutations even not treatable in some cases of hbsag mutations
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Avatar_m_tn
the only first line drugs for hbv are: tenofovir (most potent, no resistance), entecavir (resistance very high on lamivudine users so it cannot be used if not naive to treatment), peginterferon

many years of tenofovir (3-6years) and then peginterferon add on are showing 50% cure of hbv by 1 year of combo, al low hbsag less than 1000iu/ml is a good time to add on peginterferon to clear definitively in more cases
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