Chlorogenic acid

[hatehep]

Publication: Antiviral research
Publication Date: 2009
Study Author(s): Wang, Gui-Feng;Shi, Li-Ping;Ren, Yu-Dan;Liu, Qun-Fang;Liu, Hou-Fu;Zhang, Ru-Jun;Li, Zhuang;Zhu, Feng-Hua;He, Pei-Lan;Tang, Wei;Tao, Pei-Zhen;Li, Chuan;Zhao, Wei-Min;Zuo, Jian-Ping;
Institution: Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China.

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Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse Antiviral activity. In this study, HepG2.2.15 cells and duck Hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and Caffeic Acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.

[stef2011]

thanks, we ll check the full study to see if there is any suggested dose in vivo, again this may have an effect on those on peg, off therapy this may help on firbosis/hcc prevention only

[The_PS]

Here is the link to the study

http://www.sciencedirect.com/science/article/pii/S0166354209003258?via=ihub

[stef2011]

is there a link to full study?what is the level of chlorogenic acid used?

we do know already there is a boosting of peginterferon response from 4 cups of coffee per day and a liver cancer prevention effect.this will never clear hbv but the dose of green coffee pills to be used while on peg is interesting

if we can t get this data from the study it is useless