Chronic Hepatitis B Outlook & Prognosis

[paak]

I am 30 years old. I have been inactive carier of Hepatitis B for several years with negative PCR and normal LFT and negative HbeAg until 2014. In Nov 2014, I had HBV DNA 51800 copies per ml, LFTs were normal and AFP resulted in 11 IU/ml. I started Entecavir 0.5 mg daily. At this stage, I also got HbsAg Quantitative and value was 393 IU/ml. I am continuing Entecavir since then (almost 3 years). Last year, I developed gallstone and I got laproscopic cholecystectomy done also. At that time LFTs were normal also.
Two weeks ago, I started feeling mild pain and severe discomfort in upper right abdomin leading towards back. I thought it to be something wrong with liver. I got Ultrasound and it showed normal, then I got LFTs they were normal (ALT 16, AST 15, Bilirubin 0.5 etc.). CBC showed slight increase in Lymphocytes over Neutrophils and platelets were 236,000. I went to my surgeon and he said that ultrasound seems to be normal. I went to my Hepatologist and he said that everything is ok, it may be a muscular pain. He advised PCR. I got Quantitative PCR done last week (after three years) and it showed 13 IU/ml. Then I got LFTs again and they were normal, and CBC showed 4.1 Lymphocytes (further increased) and 151,000 platlets (further decreased in 4-5 days). I was worried, then i got HbsAg quantitative and it showed 452.87 IU/ml. 4 days later I again got CBC done and it showed that lymphocytes were further increased to 4.7 while platelets improved to 300,000. I generally feel weakness in body. Now pain is little bit less but i am worried of my current condition. I am continuing the Entecavir. I am afraid of liver cancer or other such complications. I would request your review of my HBV status and give your expert opinion as to what I need to test again and any changes in treatment if required. Thanks.

[paak]

Will request other members especially @Stef2011 to provide your feedback.

[Bravesoul]

Dude you're soo lucky. Someone with your profile has a risk for any liver related events similar to a non-infected individual. As long as your HbsAg stays low and you mantain undetectable DNA on therapy, you have nothing to worry about my friend. Also, you stand an excellent chance to clear HbsAg eventually,given your age. Cheers!

[paak]

Thanks for your feedback @Bravesoul. I am actually unable to categorize the pain in upper right quadrant of my abdomen. My cholesterol levels are high (250) and Uric acid is also at upper normal border (7). I dont know what could be the reason of pain, whether it is liver related to any complication of gall bladder removal.