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Avatar universal

Clarity on Hepatitis tests - window period

Hi all,

I got tested for Hepatitis B & C in Dec 2009. HBSAg and Anti-HCV were both negative. At the time, I also got the qualitative PCR tests for both done which were also negative.

I had a possible exposure at the end of March 2010. Therefore I got myself tested on the 5th of June i.e. 2 months later for HBSAg, anti-HBC, HB Surface Antibody, Hep A, Hep E and anti HCV as well as the PCR's for both. Everything was -ive including surface antibody (which means I need to get vaccinated).

My question is whether I can count myself as -ive for both Hep B and C based on the tests and the timelines above?  if I get tested during the window period then HBSAg and Anti HCV would fail but surely the PCR wouldnt?

Looking forward to your responses.

Thanks
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Avatar universal

you have to wait 6 months, you might have no signs for a long time but if you are clever you can make vaccine anyway if hbsag still negative
Helpful - 0
Avatar universal
You are right about the recommendation.  However my point w.r.t effectiveness of tests is:

PCR > HBSAg in the window period (viral loads high, antibodies low)
PCR < HBSAg after window period (because viral loads may fluctuate after initial infection)

So theoretically, a negative PCR at 1-2 months for Hep B should be conclusive?  and similarly a negative HBSAg at 6 months? but not vice versa?  

Need some clarity from medical professionals here.

Thanks
Helpful - 0
Avatar universal
CDC recommended the test at 4 weeks in range 1 to 9 weeks
but there is someone here who took three months to test positive
and its very rare to take up to three months as all doctors said
am in the same situation with u I tested negative at 9 weeks and I will retest at 13 weeks I hope it come back negative  
Helpful - 0
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