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Combo Treatment: Baraclude + Viread (results)
Hey guys, I'm new to the forum -- I just found the thread through Google by searching Viread + Baraclude. My apologies if I ask a few stupid questions, I'm still learning a lot about HepB. =]
I want to start off by saying that I have been taking both Baraclude + Viread as part of a study in November. I will try to be specific as possible, but all my paperwork and results are back at home since I'm away for college. I'm a 23 year old Asian male and found out I had chronic HepB.
---------------------------------------------------DATA---------------------------------------------------
• 1st blood results were (taken in 07/18/2008). NOT ON TREATMENT
HEPATITIS B VIRAL DNA, QUANT PCR 1,630,000,000 H <160 copies/mL
• 2nd blood results were (taken in 08/19/2008). NOT ON TREATMENT
HEP B VIRAL DNA QT 1,020,000,000 H <160 copies/mL
*some fluctuation in numbers, but still very high
♦I started the combo drugs sometime in November with the high DNA count above, if not more.
• 3rd blood results were (taken in December 2008): ON TREATMENT
HEP B VIRAL DNA QT 300,000 H <160 copies/mL
• 4th blood results were (taken in January 2009): ON TREATMENT
HEP B VIRAL DNA QT 801 H <160 copies/mL
• 5th blood results were (taken in April 2009): ON TREATMENT
HEP B VIRAL DNA QT 201 H <160 copies/mL
My doctor said the goal is to get my HepBeAG to turn negative as it is the engine behind the whole process, and the viral count to Zero.
At the moment, I'm HepBeAB negative, and HepBeAG positive.
Please feel free to ask any questions, and hopefully I'll be able to do the same as well as provide answers.
Thanks everyone! Will keep everyone up to date!
I want to start off by saying that I have been taking both Baraclude + Viread as part of a study in November. I will try to be specific as possible, but all my paperwork and results are back at home since I'm away for college. I'm a 23 year old Asian male and found out I had chronic HepB.
---------------------------------------------------DATA---------------------------------------------------
• 1st blood results were (taken in 07/18/2008). NOT ON TREATMENT
HEPATITIS B VIRAL DNA, QUANT PCR 1,630,000,000 H <160 copies/mL
• 2nd blood results were (taken in 08/19/2008). NOT ON TREATMENT
HEP B VIRAL DNA QT 1,020,000,000 H <160 copies/mL
*some fluctuation in numbers, but still very high
♦I started the combo drugs sometime in November with the high DNA count above, if not more.
• 3rd blood results were (taken in December 2008): ON TREATMENT
HEP B VIRAL DNA QT 300,000 H <160 copies/mL
• 4th blood results were (taken in January 2009): ON TREATMENT
HEP B VIRAL DNA QT 801 H <160 copies/mL
• 5th blood results were (taken in April 2009): ON TREATMENT
HEP B VIRAL DNA QT 201 H <160 copies/mL
My doctor said the goal is to get my HepBeAG to turn negative as it is the engine behind the whole process, and the viral count to Zero.
At the moment, I'm HepBeAB negative, and HepBeAG positive.
Please feel free to ask any questions, and hopefully I'll be able to do the same as well as provide answers.
Thanks everyone! Will keep everyone up to date!
aslo do consider heptech and read all researxh behind it, it will keep you free of fribrosis and probably allow viread without damaging kidneys
hep tech is not a drug company but a team of researchers, the most advanced in the world about liver, which teamed to produce it, study it and make human trials for the studies.it is ll antioxidants so it is good or everybody except it is expensive
Thank you so much for providing value information.
I had liver biopsy in early 2000 and saw few scar tissues but functioning normal and viral level was undetectable. This was few years after taking viread.
Since than I had CT scan regularly and no changes noticed. However, I had false alarm because they saw tumor on liver in late 2000 and I had to go through 3 days of testing to put me on liver+ kidney transplant( by the way, doctors were so sure they did not bother to biopsy to confirm I have cancer. I was at UCLA). But it turns out to be a false so I am not sure it was good thing I did not have cancer or it would been better to have liver + kidney transplant same time because I heard it would be better to get liver and kidney from same person rather than receiving kidney and later get liver from different individual then it will create whole a lot new problems to deal with.
I will talk to my doctor about resistance test so I know what to expect with drug resistance and ask about new version of tnf without kidneys damage.
I had liver biopsy in early 2000 and saw few scar tissues but functioning normal and viral level was undetectable. This was few years after taking viread.
Since than I had CT scan regularly and no changes noticed. However, I had false alarm because they saw tumor on liver in late 2000 and I had to go through 3 days of testing to put me on liver+ kidney transplant( by the way, doctors were so sure they did not bother to biopsy to confirm I have cancer. I was at UCLA). But it turns out to be a false so I am not sure it was good thing I did not have cancer or it would been better to have liver + kidney transplant same time because I heard it would be better to get liver and kidney from same person rather than receiving kidney and later get liver from different individual then it will create whole a lot new problems to deal with.
I will talk to my doctor about resistance test so I know what to expect with drug resistance and ask about new version of tnf without kidneys damage.
there is also a new version of tnf without kidneys damage, i posted about 1 years ago
i remember the name now
http://www.chimerix.com/
http://www.chimerix.com/therapeutic-programs/category/cmx157
i think they want to rycle viread as patent expires and this should not be allowed because the patent can go on forver if you just change parts of the chemical...but anyway this has no kidneys tox, this would be the solution if you can get it.
it will reach market as tnf expires, i guess around 2015
sorry too tired read fibroguard as fbroscan...
fibroguard is just a blend of antioxidants that are able to regress cirrhosis/fibrosis and of course has good influence is on all organs.check hepatitistechnologies website
with the transplant story is getting very complicated, you should have a resistance test first to know all mutants for sure, possibly a test that can reach as low as 5% of virus population, so that we can get even the low level mutants and then choose tnf+etv
heptech is also used without antivirals and is able to stop fibrosis/regress cirrhosis despite active viral infection with hbv or even hbv+hcv+hdv superinfection but in your case you have immune suppressive drugs so not an option without antivirals
what is your liver damage on biopsy or fibroscan?
Is it FDA apporved....
forget FDA, it is a disgrace for US citizens, nothing to do with sfety.please refer to europeans FDA which has much less influence from durg makers and more reliable
fibroscan is the only tool to see and monitor liver damage, it is not approved in US and probably never will because we have it available since year 2004.the reason is probably put everyboy on antivirals because biopsy cannot monitor liver damage but you can just make it once in years
US is getting to the point that they cannot present good data because biopsy is no longer used in europe/asia to detect liver damage because fibroscan is the main tool for that
forget FDA, it is a disgrace for US citizens, nothing to do with sfety.please refer to europeans FDA which has much less influence from durg makers and more reliable
fibroscan is the only tool to see and monitor liver damage, it is not approved in US and probably never will because we have it available since year 2004.the reason is probably put everyboy on antivirals because biopsy cannot monitor liver damage but you can just make it once in years
US is getting to the point that they cannot present good data because biopsy is no longer used in europe/asia to detect liver damage because fibroscan is the main tool for that
Hi
Thanks for your comments.
Before I answer your question let me explain situation I am in.
I start HepB treatment about 11 years ago with epivir and within a year I start developed resistance so I switched to Hepsera for about 10 years ago and swithed to viread 4 years ago to present time because it is better drug. But while I was taking Hepsera my kidney failed( I might had weak kidney but I blame hepsera for blame) and I was on dialysis last 8 years until I had kidney transplant this year July.
We are aware of how toxic viread is to kidney and taking viread was o.k while I was on dialysis because my kidney was already not working but now I need to use new drug to lower hep B virus and same time protect my new kidney.I was taking 2 viread per week after transplant but doctor just increased to 3 per week. This is why we are thinking about combo treatment. So instead of keep increasing Viread as my kidney function become normal we want to add baraclude as supplemental drug.
My option is switch to baraclude until it develop resistance and give kidney to fully recover from surgery or use combo treatment of viread as primary drug and baraclude as supplemental drug and hope it will give more time to develop resistance.
And about fibroguard. Is it FDA apporved drug or supplemental health drug?
I am not sure my doctor will approve to use of fibroguard. I'll do some research to do. Thank you.
Thanks for your comments.
Before I answer your question let me explain situation I am in.
I start HepB treatment about 11 years ago with epivir and within a year I start developed resistance so I switched to Hepsera for about 10 years ago and swithed to viread 4 years ago to present time because it is better drug. But while I was taking Hepsera my kidney failed( I might had weak kidney but I blame hepsera for blame) and I was on dialysis last 8 years until I had kidney transplant this year July.
We are aware of how toxic viread is to kidney and taking viread was o.k while I was on dialysis because my kidney was already not working but now I need to use new drug to lower hep B virus and same time protect my new kidney.I was taking 2 viread per week after transplant but doctor just increased to 3 per week. This is why we are thinking about combo treatment. So instead of keep increasing Viread as my kidney function become normal we want to add baraclude as supplemental drug.
My option is switch to baraclude until it develop resistance and give kidney to fully recover from surgery or use combo treatment of viread as primary drug and baraclude as supplemental drug and hope it will give more time to develop resistance.
And about fibroguard. Is it FDA apporved drug or supplemental health drug?
I am not sure my doctor will approve to use of fibroguard. I'll do some research to do. Thank you.
viread cannot be used on those with kidneys disfunction, i am one of those....but fibroguard is able to repair kidneys and lower creatinine, i do think you should try fibroguard and see if you can tollerate viread, this is because once you hve epivir (lamivudine) resistance there are no drugs except tenofovir
what combo are you going to make?without tenofovir there are no comboes that can work on you
you may try: interferon+tenofovir (viread) but i d never use entecavir even in combo because with epivir resistance you are already resistant to etv
Are you treated in this study :"Entecavir Plus Tenofovir Combination Therapy Versus Entecavir Monotherapy in Naive Subjects With Chronic Hepatitis B" ?
How about your test ?
How about your test ?
I am about to start combo treatment.
What was your drug combination dosage?
I developed resistance with epivir so I can not use baraclude alone and Viread is too toxic so we are going to try combo treatment so I am interested in your Recipe.
What was your drug combination dosage?
I developed resistance with epivir so I can not use baraclude alone and Viread is too toxic so we are going to try combo treatment so I am interested in your Recipe.
good to know this combo can be stopped on hbe seroocnversion by using only one drug.do you know the reason to use entecavir instead of tenofovir since it is a weaker drug?you have also to consider that tenofovir has 16% hbsag seroconversion by 3 years on hbeag positive at start of therapy so entecavir was really a bad choice since hbsag seroconversion is much lower than tenofovir for you
did they measure your hbsag quantity?
are you still with the researchers now or switched to normal liver specialists?i guess the next best move is a combo of entecavir with immune modulators like interferon and alinia
Update! Sorry for the delay.
@bram44: 0 H count is definitely a first step. However, I have not sero converted. Until around November, 2010, my combo treatment ended and I was transferred onto another study, but only on one medication: Baraclude.
@longman555: I live in California.
@stefano170669: What is "immune tollernat fase"?
• I was only notified of my Chronic HepB. I only had a liver ultrascan which did not show signs of tissue scarring.
• No adverse kidney issues.
I feel normal. Been trying to train for a half-marathon happening next weekend.
I am now on Baraclude, one pill a day.
@bram44: 0 H count is definitely a first step. However, I have not sero converted. Until around November, 2010, my combo treatment ended and I was transferred onto another study, but only on one medication: Baraclude.
@longman555: I live in California.
@stefano170669: What is "immune tollernat fase"?
• I was only notified of my Chronic HepB. I only had a liver ultrascan which did not show signs of tissue scarring.
• No adverse kidney issues.
I feel normal. Been trying to train for a half-marathon happening next weekend.
I am now on Baraclude, one pill a day.
sorry i confused this is not a good example: he had hbs-ab by vaccine but when got hcv hbs-ab disappeared and got hbv as well, it was very bad luck because got viruses from a needle
but what i meant is that some virus is left in the body even after hbs-ab so taking viread is not bad because you can reach a similar state taking a viread pill
but what i meant is that some virus is left in the body even after hbs-ab so taking viread is not bad because you can reach a similar state taking a viread pill
by the way your goal is prevent cancer and cirrohsis and viread is the most potent antiviral for this, once dna is 0 you are in the same situation as if you have hbs ab...you just need to take a pill to keep this state
consider that when you make hbs ab you still have the virus in the body and also some dna, infact you cannot donate blood/organs even if your hep B is complitely cleared by years
i know a doctor who had hep B and was complitely healed but after taking hep C several years later also hep B came back....
consider that when you make hbs ab you still have the virus in the body and also some dna, infact you cannot donate blood/organs even if your hep B is complitely cleared by years
i know a doctor who had hep B and was complitely healed but after taking hep C several years later also hep B came back....
if your liver has mild fibrosis take something to cure depression
your own body cannot cure infection, if you have hbvdna detectable your body can only help you to die with cancer or cirroshis....
stopping antivirals can be very very dangerous, especially if your liver is damaged already, just talk to your doctor about it maybe you can switch to entecavir but the forum is not the right place for this, your doctor will be able to make the right choice for you
I have just started taking viread three days before. After Reading all above I am now depressed. In my case I do not have any goal from my treatment as I am already e antigen negetive.
Should I carry on taking viread to lower my viral count or leave it and put myself on natural response of my own body? As in both cases I have to suffer and die so then why to take treatment?
Can I take herbal medicine and milk thistle alongwith viread?
I am depresed and need motivation from you people.
Should I carry on taking viread to lower my viral count or leave it and put myself on natural response of my own body? As in both cases I have to suffer and die so then why to take treatment?
Can I take herbal medicine and milk thistle alongwith viread?
I am depresed and need motivation from you people.
sorry for mistakes:
any adverse event on kidneys?
did you have a liver bipsy or fibroscan at start of treatment?
thank you
any adverse event on kidneys?
did you have a liver bipsy or fibroscan at start of treatment?
thank you
hi, can you also clear with your doctor if you were in the immune tollernat fase when you started or just cronic hbe +
it is very good to see that such high hbv-dna can be suppressed so fast by the combo of most potent antivirals, any adverse event of ?
did you have a liver bipsy or fibroscan at start of treatment kidneys?
thank you
it is very good to see that such high hbv-dna can be suppressed so fast by the combo of most potent antivirals, any adverse event of ?
did you have a liver bipsy or fibroscan at start of treatment kidneys?
thank you
Reaching 0H is first step. Please share your success story e-sero conversion (or s-sero conversion)
I have not actually seen my latest results, the last ones were at
• 5th blood results were (taken in April 2009): ON TREATMENT
HEP B VIRAL DNA QT 201 H <160 copies/mL
The 6th blood results should already be out, but I haven't had the chance to review them at the office yet. The doctor said that I should be at a count of at least 0 H (yes, zero). But that doesn't mean that I've cured of it. The treatment only suppresses the virus.
I am still on the combo treatment and will continue to be on it for the next year. The program is for a total of two years.
I apologize that I can not assist you, jammy65, as I am located in California, USA...
• 5th blood results were (taken in April 2009): ON TREATMENT
HEP B VIRAL DNA QT 201 H <160 copies/mL
The 6th blood results should already be out, but I haven't had the chance to review them at the office yet. The doctor said that I should be at a count of at least 0 H (yes, zero). But that doesn't mean that I've cured of it. The treatment only suppresses the virus.
I am still on the combo treatment and will continue to be on it for the next year. The program is for a total of two years.
I apologize that I can not assist you, jammy65, as I am located in California, USA...
Thank you all for this discussion that will definitely give some postive spirit to all the patients to fight with the virus.
Hepbinme: i would like to know you are from which place. If you are from India i would like to know the doctur you are consulting.
Hepbinme: i would like to know you are from which place. If you are from India i would like to know the doctur you are consulting.
I just wanted to let you guys know that I didn't forget about this thread.
I will be going back for my scheduled visit this Friday, July 11, 2009, for another usual check-up. (includes a physical and blood test).
I will keep you guys updated!
I will be going back for my scheduled visit this Friday, July 11, 2009, for another usual check-up. (includes a physical and blood test).
I will keep you guys updated!
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