Aa
Confused whether acute or chronic
I had got hep-b vaccination when i was 13yrs old.Now when i got a regular medical check up done my sgpt/sgot was very high(SGOT-188,SGPT-479).
On further check i my results were as follows:
HBV DNA 1284000 iu/ml
Prothrombin Time 13.4sec
INR 1.01
Anti Hav Igm Negative
Anti Hev IGM Negative
Anti body to Heptatis C:Negative
HBeAG; Negative
Anti HBcAG-IgM Negative
Anti HBc (Total) Positive
Ultrasound was normal and liver doppler test was normal
Post that i was asked to tak entacavir 0.5mg daily and now after 3.5 months of 1st diagnosis my viral count has come down to 625iu/ml and SGPT/SGOT are also normal.
The doubt that i have is
1 Am i suffering from chronic or acute Hep-b
2 How did i get it since i was vaccinated as a child?
3 Can this be cured
4 Can i consume beer once in a while
On further check i my results were as follows:
HBV DNA 1284000 iu/ml
Prothrombin Time 13.4sec
INR 1.01
Anti Hav Igm Negative
Anti Hev IGM Negative
Anti body to Heptatis C:Negative
HBeAG; Negative
Anti HBcAG-IgM Negative
Anti HBc (Total) Positive
Ultrasound was normal and liver doppler test was normal
Post that i was asked to tak entacavir 0.5mg daily and now after 3.5 months of 1st diagnosis my viral count has come down to 625iu/ml and SGPT/SGOT are also normal.
The doubt that i have is
1 Am i suffering from chronic or acute Hep-b
2 How did i get it since i was vaccinated as a child?
3 Can this be cured
4 Can i consume beer once in a while
sorry for troubling you but one quick one.i was under the impression that antivirals had no affect on HBSAG count,then how come my hbsag quantitative went down from 9383 to 5865 iu/ml in 2 weeks.
Hey got my test results again today ,HBV DNA has come down to 95 iu/ml and HBSag quantitative has become 5865 iu/ml.
1 HBsag has reduced from 9383 to 5865 iu/ml in 2weeks--is it because of entacavir?does the count fluctuate like this? can it be a case of acute hapatitis.will the count increase??
1 HBsag has reduced from 9383 to 5865 iu/ml in 2weeks--is it because of entacavir?does the count fluctuate like this? can it be a case of acute hapatitis.will the count increase??
1 i have become short tempered and have major mood swings..can this be because of baraclude
no that s immune system cytokines.liposomals, vit d3 and fish oil high dha/epa at least 3g are needed to balance.check thyroid too
2 Does chronis HEP-B/baraclude have an impact on memory.i seem to not remember things that well.
no
3 Getting my wife hep-b vaccination.what test shall i get done after she gets the booster dose and after a gap of how long after the booster dosage.
hbsab to be hgiher than 10miu/ml
4 Can hep-B virus spread through saliva/french kiss
no
no that s immune system cytokines.liposomals, vit d3 and fish oil high dha/epa at least 3g are needed to balance.check thyroid too
2 Does chronis HEP-B/baraclude have an impact on memory.i seem to not remember things that well.
no
3 Getting my wife hep-b vaccination.what test shall i get done after she gets the booster dose and after a gap of how long after the booster dosage.
hbsab to be hgiher than 10miu/ml
4 Can hep-B virus spread through saliva/french kiss
no
1 i have become short tempered and have major mood swings..can this be because of baraclude
2 Does chronis HEP-B/baraclude have an impact on memory.i seem to not remember things that well.
3 Getting my wife hep-b vaccination.what test shall i get done after she gets the booster dose and after a gap of how long after the booster dosage.
4 Can hep-B virus spread through saliva/french kiss
2 Does chronis HEP-B/baraclude have an impact on memory.i seem to not remember things that well.
3 Getting my wife hep-b vaccination.what test shall i get done after she gets the booster dose and after a gap of how long after the booster dosage.
4 Can hep-B virus spread through saliva/french kiss
1 if the hbv dna becomes undetectable will the hbsag number also come down?
no they are two different things, it may come down but it is not correlated to hbvdna, you can have hbvdna und or detectable and hbsag going down
2 is there a medicine to reduce hbsag count
no the only way is using tenofovir for 5 years (50% get hbsag below 1000iu/ml by 5 years) and when hbsag is so low add on peginterferon.doing this most will lose hbsag
3 i had heard there were some clinical trials with birinapant+entecavir which removed hbsag completly
these are trials and i am not sure if it removed hbsag, link the study
4 what does the count depend on?why is it that some have high and some low in chronic HBV also
hbsag depends on number of infected cells and your immune system being able to kill infected cells
no they are two different things, it may come down but it is not correlated to hbvdna, you can have hbvdna und or detectable and hbsag going down
2 is there a medicine to reduce hbsag count
no the only way is using tenofovir for 5 years (50% get hbsag below 1000iu/ml by 5 years) and when hbsag is so low add on peginterferon.doing this most will lose hbsag
3 i had heard there were some clinical trials with birinapant+entecavir which removed hbsag completly
these are trials and i am not sure if it removed hbsag, link the study
4 what does the count depend on?why is it that some have high and some low in chronic HBV also
hbsag depends on number of infected cells and your immune system being able to kill infected cells
1 if the hbv dna becomes undetectable will the hbsag number also come down?
2 is there a medicine to reduce hbsag count
3 i had heard there were some clinical trials with birinapant+entecavir which removed hbsag completly
4 what does the count depend on?why is it that some have high and some low in chronic HBV also
2 is there a medicine to reduce hbsag count
3 i had heard there were some clinical trials with birinapant+entecavir which removed hbsag completly
4 what does the count depend on?why is it that some have high and some low in chronic HBV also
What should i do next.Whats the way forward?
keep using the antiviral, this is not acute hbv hbsag is too high
entecavir is not the best choice, tenofovir is more potent on hbsag when hbvdna is fully undetectable for few months you may choose to switch to tenofovir
keep using the antiviral, this is not acute hbv hbsag is too high
entecavir is not the best choice, tenofovir is more potent on hbsag when hbvdna is fully undetectable for few months you may choose to switch to tenofovir
LFT
28th Feb 13th March 9th april 16th april 21st april 16th May 13th June
SGOT 161 188 81 44 43 29 25
SGPT 381 479 254 96 77 37 30
GGTP 62 44 32 31 18 20
Alkine phosphate (ALP) 62 79 83 81 72 67
Bilirubin Total 1.3 1.2 0.84 1.03 0.98 1.22
Bilirubin Direct 0.2 0.1 0.15 0.18 0.21 0.24
Bilirubin Indirect 1.1 1.1 0.69 0.85 0.77 0.98
Total Protein 7.0 7.5 7.01 7.39 6.61 7.03
Albumin 4.4 4.6 4.49 4.74 4.32 4.52
A:G ratio 1.7 1.5 1.78 1.79 1.89 1.8
28th Feb 13th March 9th april 16th april 21st april 16th May 13th June
SGOT 161 188 81 44 43 29 25
SGPT 381 479 254 96 77 37 30
GGTP 62 44 32 31 18 20
Alkine phosphate (ALP) 62 79 83 81 72 67
Bilirubin Total 1.3 1.2 0.84 1.03 0.98 1.22
Bilirubin Direct 0.2 0.1 0.15 0.18 0.21 0.24
Bilirubin Indirect 1.1 1.1 0.69 0.85 0.77 0.98
Total Protein 7.0 7.5 7.01 7.39 6.61 7.03
Albumin 4.4 4.6 4.49 4.74 4.32 4.52
A:G ratio 1.7 1.5 1.78 1.79 1.89 1.8
well got my result today.
Hbsag quantitative is 9383.25 iu/ml, hbv dna 215 iu/ml, LFT normal with bilirubin direct at 0.24 and total biluribin at 1.22.
I am now on entacavir-bara clude for the past 3months and original hbvdna count was 1284000.
What should i do next.Whats the way forward?
Hbsag quantitative is 9383.25 iu/ml, hbv dna 215 iu/ml, LFT normal with bilirubin direct at 0.24 and total biluribin at 1.22.
I am now on entacavir-bara clude for the past 3months and original hbvdna count was 1284000.
What should i do next.Whats the way forward?
little effect on hbsag, very few patient get reduction while 50% get levels below 1000iu/ml by 5 years of tdf (not etv)
Got my blood test for HBSAG quantitative awaiting results.Does baraclude-entracavir cure HBSAG damaged cells.As in does it help in reducing the count.
3 isnt hbv dna viral load the same as hbsag quantitative test?
no complitely different test with nothing to do in common, hbvdna is replication and hbsag reflects infected cells.you can have undetectable replication but a lot of infected cells
no complitely different test with nothing to do in common, hbvdna is replication and hbsag reflects infected cells.you can have undetectable replication but a lot of infected cells
1 i dont have any kidney issue but the doctor advised me to take entecavir,told me this is the best medicine available.Can i change to tenofovir ,will it help?(
tdf is more potent especially on hbsag although all antivirals have little effect on it
2 parents dont have hep-b
you got it in childhood probably
3 isnt hbv dna viral load the same as hbsag quantitative test? i was asked to get it done in march and the again in may and the count has come down from 1284000 to 625 iu/ml.
it was not high, you can keep also etv, just check that hbvdna gets und by 6-8month otherwise best tdf
4 can it be an acute case and go away in 6 months?
no it is not acute
tdf is more potent especially on hbsag although all antivirals have little effect on it
2 parents dont have hep-b
you got it in childhood probably
3 isnt hbv dna viral load the same as hbsag quantitative test? i was asked to get it done in march and the again in may and the count has come down from 1284000 to 625 iu/ml.
it was not high, you can keep also etv, just check that hbvdna gets und by 6-8month otherwise best tdf
4 can it be an acute case and go away in 6 months?
no it is not acute
my viraL DNA was very high to the tune of 1284000 iu/ml in march.its come down to 625iu/ml in 3.5months .dont know whether on its own or because of entacavir.can this be a case of acute?
1 i dont have any kidney issue but the doctor advised me to take entecavir,told me this is the best medicine available.Can i change to tenofovir ,will it help?(
2 parents dont have hep-b
3 isnt hbv dna viral load the same as hbsag quantitative test? i was asked to get it done in march and the again in may and the count has come down from
1284000 to 625 iu/ml.
4 can it be an acute case and go away in 6 months?i am healthy other wise and have no problems.wont have got to know about this if had not gone for a rgular medical check up.does acute case have a high viral load of 1284000 iu/ml.
2 parents dont have hep-b
3 isnt hbv dna viral load the same as hbsag quantitative test? i was asked to get it done in march and the again in may and the count has come down from
1284000 to 625 iu/ml.
4 can it be an acute case and go away in 6 months?i am healthy other wise and have no problems.wont have got to know about this if had not gone for a rgular medical check up.does acute case have a high viral load of 1284000 iu/ml.
you are missing the most importan t test, hbsag quantitative in iu/ml, this will tell you if you are getting rid of infected cells, have this test as soon as possible because you need a baseline value and then follow every 6-12motnhs
1 Am i suffering from chronic or acute Hep-b
chronic before you took vaccine, probably at birth or when very young
2 How did i get it since i was vaccinated as a child?
if your mother has hbv you must take vaccine at birth, if mother negative you need it anyway when very very young...all adults clear so taking vaccine at 13yo is not that useful, too late
3 Can this be cured
hbsag lowers after 5 years of tenofovir, the most potent hbv antiviral.entecavir was not the best choice unless you have damaged kidneys
4 Can i consume beer once in a while
no
chronic before you took vaccine, probably at birth or when very young
2 How did i get it since i was vaccinated as a child?
if your mother has hbv you must take vaccine at birth, if mother negative you need it anyway when very very young...all adults clear so taking vaccine at 13yo is not that useful, too late
3 Can this be cured
hbsag lowers after 5 years of tenofovir, the most potent hbv antiviral.entecavir was not the best choice unless you have damaged kidneys
4 Can i consume beer once in a while
no
Chances are, you were chronic since birth. When you parents vaccinated you at 13, you probably had a tiny bit in you but at the time more tests were not available and your parents just did the standard thing of vaccination. Most chronic cases are from birth and come from the mother. If your mother can test for Hep B, then you can confirm that this is how you got it. There is also a chance you got it within the first 5 years of your life and never cleared because immunity is low. Your viral DNA suggests that it's chronic, because chronic is usually a lower number like this.
Unfortunately, no cure. 95% of acute cases in adult clear it naturally but again this does not sound like an acute case.
Stay away from beer (though my doctor told me drinking on occasion was ok.. and when he means by occasion, have maybe one every few months AT an occasion like a wedding is ok and even still, be careful!)
Unfortunately, no cure. 95% of acute cases in adult clear it naturally but again this does not sound like an acute case.
Stay away from beer (though my doctor told me drinking on occasion was ok.. and when he means by occasion, have maybe one every few months AT an occasion like a wedding is ok and even still, be careful!)
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