you have to know (ur doctor should be very aware of this so change it if it didn t tell you) that hbv is not pathogenic, it means it makes no damage to our body.it is the immune system that makes the damage killing the infected cells producing the virus
with such high viral loads the state is immune tollerant (no immune response), this means no dammage at all, so you are in the best stage of hbv infection, perfectly healthy, and hope to stay in this stage as long as possible
your liver during this stage is even healthier since the virus changes free radical protection genes of infected cells making them more strong and living longer than others
as long as hbvdna, hbsag stay at high range numbers and alt/ast stay about normal you are immune tollerant.in case alt/ast are a little abpve normal range you have to check if it is immune response starting or justfatty liver/unhealthy life to make alt a little higher than normal.a fibroscan or biopsy is ofetn needed to be 100% sure you are immune tollerant
the best time to start a therapy is when your immune system will start with interferon and alinia while entecavir/tenofovir are useless on virus
at this stage no therapy is needed and no therapy can work
In 2000 I was diagnosed with Chronic Hep B. I did Interfuron and Hepsera over the years as well as Epivir. In 2006 I was told that my viral load was undetectable.
my god, you got the crazy doctors to make you a mess, hbvdna has no meanning in terms of clearing infection and unfortunately ignorant doctors don t know that.
lamivudine and adefovir were taken together with interferon?without interferon you might have the very dangerous hbv mutants from those antivirals and unfortunately once you get those mutants liver cancer risk remains very high even with hbvdna undetactable, the only chance is to get hbsag negative
did you make hbv polimerase, pcp and precore mutants tests?
The doctor wants to start me on Baraclude....as to doctor if he was in italy i'd sue him for every mutant developped.go to the best doctors and liver center in the country, if you can afford it move to harvard boston or HR in LA, i can PM their names
baraclude cannot be used at this point because several mutants might be present (baraclude don t work with mutants it will develop other muatnts if used monotherapy) and hbv dna is too high for an antiviral to work.i guess the high hbvdna is due to mutants not immune tollerant at this point.
after we know the mutants i'd start:
tenofovir+entecavir+alinia and see if they can get hbvdna down but we have to be sure about the type of mutants you have to choose entecavir or other
there was an asian guy on the forum with hbvdna in the billions and tenofovir+entecavir worked
tenofovir and alinia are active on all mutants, be aware that if you have those mutants you need a researcher or very expert doctor, no just a liver specialist, becuase wrong choices can get the situation even worst.
baraclude monotherapy was a very wrong choice, plus these antivirals can t be used without checking the resistant mutants
as to alinia (nitazoxanide) check all the posts in the community since it is not covered by insurance companies and brand from romark is way too expensive a generic from lupin would be the best choice.it is also off label so it is not easy to find a doctor to prescribe but it has no sides and allowed even on 1yo babies so it is easy to get it even without prescription at canadian pharmacies
all antivirals have no effect on virus infection, they only lower hbvdna which is responsible of liver damage but even when hbvdna is undetactable the infection goes on and on many cases it gets worst spreading to other cells.
so if you stop these therapies or develop resistance you have more infected cells which start producing virus so hbvdna wil be higher than before and also alt/ast
so the point is these therapies cannot be stopped and resistance cannot develop because the infection is even worst so managment of therapy is not easy
the only test that can tell you if you are getting less infected cells is hbsag quantity in the serum or even better in the biopsy
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