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Cured from Chronic Hepa B what's next?
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Cured from Chronic Hepa B what's next?

Good day to everyone!

I'm a chronic Hepatitis B patient who just got cured. I was inactive carrier for more than 10 years, then chronic active for the last 4 years. I started treatment more than 2 years ago because my HBV DNA is already on maximum count and my sgpt is highly elevated to he point of being icteric. After 10 months of entecavir and natural supplementation my HBV DNA is undetectable and after 24 months my Hbeag is non reactive, Hbsag w/ titer (CMIA by Abott) is non reactive, Sgpt/sgot is normal, Anti-Hbs and Anti-hbe is still non-reactive. I like to post this question because there are very few cases like mine and I would like to hear what happens next.
How can I improve my anti-hbs and Anti-hbs? Is there any vaccination which can stimulate production of antibodies to make it reactive? Also my eosinophils is high for the past 3 months. Is this due to my immune response to eliminate Hbsag? I try to check the web for any correlation between high eosinophils and hbsag elimination but as I said there very limited cases and I can't find any more information. Any sharing of information is a great help. God Bless everyone!
Tags: high eosinophils, eosinophils, HBsAg NONREACTIVE, antibody
42 Comments Post a Comment
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Avatar_m_tn
Dear Friend,

Could you explain your case  a little bit detailed? Such as your fibrosis DNA Count, ALT-AST levels etc...
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Avatar_m_tn
first of all not cured until hbsab is undetectable, this is a must to be sure there is no relapse or low hbvdna present (what was the senibility of the pcr?)

How can I improve my anti-hbs and Anti-hbs?
peginterferon, hbv vaccine or the combo of both.normal hbv vaccine has been used in this stage but we have a member checking israel hbv vaccine which has more antigens and is much more potent than normal hbv vaccine, check his posts about his response to it


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4687027_tn?1361864228
WOW! congratz Bro!
Good is good! ^_^
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2127081_tn?1389939963
Thank you for your response. That is really my next goal and I know hbsag may go back if I don't increase my anti-hbs. My mom and I now have a similar case, she's cured from hbsag and we check her Anti-hbs quarterly and it's just fluctuating but still non-reactive. Her value is around 2-3 iu/ml and the cut-off value is above 10 to be considered reactive. My HBV DNA is 110,000,000 iu/ml before treatment, it become <6 iu/ml on month 10 of entecavir. My sgpt(kinetic) was around 300 u/l before treatment. It was down to 90 u/l on month 4 and normal on month 8 of treatment and continues to be within the normal range upto now (my sgpt now is 21 u/l). I don't think I have any liver damage before/during and after treatment so I am very lucky to start the treatment before anything serious happen. The only time I have elevated sgpt during treatment is when I acquired a Hepa A virus which is very symptomatic (aundice, pale stools, cannot eat, dark urine) That was month 5. My sgpt rise to 1400 u/l but then it subside after 2 months.

To Bibhoy: Thanks! God is really good! God Bless.
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Avatar_m_tn
God Bless you to and I'm happy to hear your positive results :)
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4687027_tn?1361864228
Amazing! ^_^
sorry for the late reply!=_+

You made it this far and I know that in time you will create the perfect anti-hbs  for eradicating completely the virus. I hope you mom will soon be cured completely too.

We are the same at entecavir and what you are experiencing is exactly what I have now but I'm gonna check again soon if I am non reactive.

This is a good thread and I hope everyone will see this and
So that anyone can ask and be encourage! Cheers! ^_^
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Avatar_m_tn
please check if also you mom had hav infection

as reported by many clinical cases a liver superinfection with benigne viruses activates immune system which is able to suppress hbvdna but your report is a first because hbv was already suppressed by entecavir and hav may be the reason of the clearance
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Avatar_m_tn
Good for you so far!

"How can I improve my anti-hbs and Anti-hbs?"

There was an in vivo study saying that, after vaccination, Coenzyme Q10 increase antibody titer: Statistics revealed that Q10 in the dose 180 mg/day is able to increase antibody response in vivo in humans vaccinated against hepatitis B with up to 57%: http://www.ncbi.nlm.nih.gov/pubmed/10416052
Is it really working or is a study sponsored by Q10 sellers?..who knows
If you want to try , keep in mind the study is about the old ubiquinone, now there is a new more potent form ubiquinol, I think.
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2127081_tn?1389939963
My doctor also have that study on superimposed HAV and HBV and told me there are reported cases of superimposed liver infection that actually eliminates both HAV and HBV. But after 6 months from acquiring HAV and still have HBV, it shows my immune response activated by HAV has not clear the virus HBV so entacavir treatment is still continued. I also think selenium supplementation plays a good role in totally eliminating the virus. I think there are studies in China showing good effects of selenium in liver cancer cases. As for my mom, she does not have HAV. Her case is different. She started lamivudine in the 90's then become inactive, then ralapse came and she took hepsera, become inactive then relapse again and took entacavir, become inactive, then another relapse again and she no longer want to take antiviral. We go natural, she took selenium, zinc and copper supplementation for 2 months and become inactive carrier and HBV DNA was down from 13,000,000 iu/ml to 6 iu/ml. Then discontinued zinc and copper as per doctor's advice and continue with selenium supplementation for more than a year. Her Hbsag (Abott Architect) was just around 700 and it no longer move that much but hbeag remained nonreactive, sgpt around 40-50 mild fatty liver. Then she took stem cell caps and Hbsag becomes nonreactive on month 4. So my mom's case was solve using purely natural  on her last relapse. But probably the antivirals she used to take also plays a major role because I tried the same natural product (except stem cell caps) but has no effect on me and I conclude that this is because of my high viral load condition which prompt me to take antiviral entecavir. These are two real life cases and I hope this can be studied and be used to solve and cure Hepatitis B. I have one more brother who is active HBV right now but still refuse to undergo medication due to financial reason. His sgpt is slightly above the range but tolerable but as soon as it goes up we will have to start treatment immediately. So i'll just stay here and read your informative post's and learn more about this disease and be part of the solution to this problem.    
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2127081_tn?1389939963
Thank you for the info. I will check if there are local suppliers here in the Philippines and review with my doctors if it is safe to use and if they have cases like mine who has positive results.

Bhiboy: Give us a feedback on your treatment results and periodic updates. Hope you will heal soon. God Bless everyone!
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Avatar_m_tn
minerals are not the reason of hbv clearance, most of us take it from a long time and are present in heptech and d3plus and most supplements.
they can only help an immune response already present by itself

the reasons can be HAV or you are among the few 5% clearing on etv
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2127081_tn?1389939963
Probably I belong to the lucky 5% clearing on etv but my mom's hbsag clearance after relapse was purely natural and we have a common element for hbsag clearance which is mineral supplementation. So I think this a good sign for medical review. Here in the Philippines there are many cases of HBV and I have a few friends in the forums who now tries this approach and I directed them to my doctor. I will report here for any updates on their treatment. The only way to prove something is to try it and look for the lab results for any improvements. Lab results will always tell the truth. This is what I did and it works for me.  
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Avatar_m_tn
mineral supplementation? can you elaborated?
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2127081_tn?1389939963
Mineral supplementation is additional intake of minerals (in my case selenium)  beyond the recommended dosage of regular multivitamins sold in the market. We have a doctor here the Philippines who studies about this approach and he has his full research on this approach. I combine this to the prescribed antiviral entacavir and it works for me. I become hbsag non-reactive in 2 years of medication. Hope this helps.  
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Avatar_m_tn
ok, salamat!

can i ask which doctor you go to?
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7584600_tn?1392265034
Is chronic hep b cureable ? Is their natural things i can or should be taking at home. ? I take milk thistle...............
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7584600_tn?1392265034
Chronic ACTIVE . i meant.sorry
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Avatar_m_tn
Theres hope for a cure from Hepb which is what we all are looking for on this site! Currently, depending on your labs, most promising direction at the moment is TNF with PegInf add on after 2-3 years. A number of members on this site have achieved clearance this way.
The horizon is full of many promising cures which might become available in the near future.
In the meantime, i would advise you to go do your labs: HBsag quantiy, HBDNA, Alt/Ast. Share results with Stef. Would give lots of helpful advise. Keep hopes alive!!!!
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7584600_tn?1392265034
Unfortunately i do not have a doctor and have not seen anyone seen anyone for my hep b since i was diagnosed at age 14. I am now 31.. this is on my to do list asap.i did not realize anything was to be done for it actually thata wahy
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Avatar_f_tn
Hi engr delacruz! I would like to see your doctor too. My doctor prescribed me lamivudine but I haven't take it yet because a friend told me that it is harmful. my hbvdna is 23 million, hbasg +ve, hbeag +ve, alt is 66 (normal is 30). thanks.
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2127081_tn?1389939963
Yes it is curable because I'm already cured. I take selenium supplementation combined with entacavir baraclude. My mom was on antiviral, then quit antiviral and started going natural. She was also cured. Every type of treatment will depend on your condition so a laboratory test should be done before any treatment or medication.
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2127081_tn?1389939963
Send me a private message so I can give you full details of my doctor. I don't think it is allowed to put doctors here the forum. Lamivudine is probably the oldest form of antiviral with some side effects, high chance of relapse. Your lab results shows you are in the active case, highly infectious. You have to monitor for 6 months if the lab results would get better or worse.  
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Avatar_n_tn
I have been taking baraclude for two and half years.My latest test reports are as follows.
HBsag-545.1 iu/ml
HBV DNA -undetectable
HBeAg - Non reactive
ALT(SGBT)-48U/L
AST(SGOT)-34U/L
All other tests are normal. can you share your history to clear hbsag?
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Avatar_m_tn
What is you biopsy or fibroscan result?
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Avatar_m_tn
I  have been using Entecavir for 3 months.

Could you write the test results before and after treatment of Entecavir?
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Avatar_m_tn
HBsag-545.1 iu/ml

with this hbsag level you can clear hbsag by adding peginterferon to entecavir in 24 to 48 weeks, check otan post and her clearance by peginterferon in less than 24weeks of treatment
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2127081_tn?1389939963
I took selenium supplementation while under baraclude treatment. My Hbsag continuously drops and become non-reactive in 24 months. Based from your result I think your Hbsag is now in a good low range and what you need to do is to boost your immune system to eliminate hbsag totally and be cured. There is peginterferon and there are also natural immune booster. It's your choice but before you try this you will have to first lower your sgpt/sgot to normal levels.  
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Avatar_n_tn
I  have already been taking a food supplement  which includes Selenium-50mcg. What is your dose of selenium supplement?
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2127081_tn?1389939963
1 ml, 3 times a day. It is in liquid form.
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Avatar_f_tn
Sir,

Goodmorning.. Would you mind letting us know po where we can find that doctor and his contact # my mom po also has hbsag reactive, Please help..

Thank you.
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Avatar_m_tn
Stef 2011, I sleep well, I eat well, I exercise well, I don't hv any problem with my body, I take fruits, I eliminated calorie intake, yet still my hbsag is still around b/n 747iu/ml and 633 iu/ml, I have taking most immune stimulants like garlic, ginger etc. help me what to do, I am not on any medication now.
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Avatar_m_tn
Hi Stef for Engr_JDelacruz i suggest he try first the normal vaccine since it s not expenssive. mean while wait for my result I will take the first shot of the SCI-b-Vac on the 30th March. The cost for this latter 4 ampouls was nearly 1600usd as not sold in israeli pharmaci and only isra med do the selling.
So it will be a wise idea for Engr_JDelacruz to start with the normal vaccine the same time i am having my isreali one taken this way after 7 months if he will not devolop HBSab i will confirm to him if he should go with isreali one after i get a clear sight in seven months time.

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Avatar_m_tn
Hi good day, i think we are same result sir, hbsag non reactive 0.29 cov 1.000
Anti hbs 7.19 non reactive cov 10.000. Feb 26, 2014 result. I took peg interferon started 2010 and ended june 2011 and my doctor gave me entecavir. And i was surprise because all my result are norma.
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2127081_tn?1389939963
My Anti-hbs is slowly elevated. It is now at 1.29 this March. I will again look at this if it will continue to go upwards and for any possibility of being reactive for anti-hbs. Just give me some feedbacks on your vaccination and for others also who are now monitoring their anti-hbs and already cleared their hbsag please let's update each others status and hoping we can all have good level of protection for Hepa B.
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Avatar_n_tn
hi,sir, I need help too,ung
hbsag ko is,2.830,can I ask po ung doctor nio gusto ko na rin gumaling,depress n ko kc di AQ makapasa pasa sa PNP dahil as kalagayan ko,please help,
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Avatar_m_tn
Use Selenium, fish oil, heaps of Vitamin C up to 4000 mg a day, zinc, B12. Make sure to drink heaps of water and you will stay healthy. I never took any treatment, my viral level went to 2000 and SGPT 280, I had constant pain in my liver. Doctor told me that I need treatment but I came across a book written by Hepatologist  in 1980s with this recipe. I start taking this stuff and after two months I my Viral level went down to 46 iu/ml and normal liver function. You need selenium and B12 to maintain low viral level and good liver function. Just make sure you drink heaps of water because these supplements will make you thirsty and body is trying to clean it self. If you don't you will have minor headaches and if you continue to take large amount of Vitamin C for long period without enough water you may end up with kidney stones. So make sure to let your body wash it self with the help of these supplements.
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Avatar_n_tn
what is the dose of selenium,zinc, B12 supplement to be taken?
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Avatar_m_tn
please answer to sundaram340.
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Avatar_m_tn
how much selinium do you and your mom take? i am barely detectable and have been on baraclude for over 5 years. David in Georgia
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Avatar_m_tn
This is a good thread and it's really encouraging!

I also know a guy in China who said he made his Hbsag non-reactive by taking selenium(yeast) and other supplements, such as zinc(yeast), bee propolis, and royal jelly. He also exercise static qigong or Tai Chi everyday. I am gonna try this way from now on. Hope this helps!
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Avatar_m_tn
Take those supplements since 2009 like so many other members here, no effect on hbsag they are only ment to keep liver oxidative stress lower and though less liver damage.he had cleared like 4%of us yearly

the cure of hbv is nucs for about 5 years and then pegintf add on and most clear like in the studies and in this forum
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Avatar_m_tn
HBsAg 3362 unit not indicated. Reactive
Anti HBs <2.00 Iu/L nonreactive
HBeAg 0.101 Nonreactive
Anti HBe 0.007 reactive
Anti HBe (IgG)  0.006 Reactive
Anti Hbe (IgM)  0.060 nonreactive.
SGPT (ALT) 51.0 U/L
SGOT (AST) 24.7 U/L
HBV DNA 374 IU/ml

Please help me understand this result for my gastro just telling me not to take any medication and just have a norml life style.
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