i am taking sebivo since 18 months. Now my DNA test is negative. So what will i do now? Will I continue taking sebivo. Have any possibility to again HB positive if i stop taking the medicine(Sebivo)?...Romel from Dhaka, Bangaldesh. ***@**** / 8801819205566
sebvivo is not a firstline drug for hbv, we have noticed that drug makers have some way made doctors prescribe these drugs in asia (they are also prescribing clevudine)
these drugs are not used because they are too weak making hbv resistance mutations, sebvivo might be considered safe if hbvdna gets und by 6 months.my opinion is it is not safe at all and have almost no meaning for hbv threapy.it has almost no effect on hbv, it just lower hbvdna which doesn t reflect any virus clearance.hbsag quantification is the only test that can show hbv clearance
i'd strongly suggest to combo with tenofovir as soon as possible to avoid resistance which might already be present (resistance might take years to show by increasing hbvdna).
tenofovir is the only antiviral for hbv with zero hbv resistance to date and it will probably never develop any resistance
it is not possible to stop a drug all at once you have to combo for 2-4months and then if you like you can discontinue sebvivo
remember that hbvdna has nothing to do with clering infection while hbvdna is und you can also get more liver cells infected (this usually happens with antiviral monotherapy) and the only way is to check if hbsag is decreasing
check also our off label combo of nitazoxanide with entecavir and tenofovir to see if we clear hbsag, until now those on combo have hbsag decreasing
all int'l guidelines for hbv allow only tenofovir,entecavir, interferon as firstline hbv therapies since very potent without hbv mutations and resistance.entecavir has 1.2% of resistance only for those without lamivudine/telbivudine (sebvivo) resistance so who took these drugs cannot use entecavir safely, it is also better to check for these resistance mutations before starting entecavir therapy because these mutations can happen also naturally not only taking lam or telbivudine (sebvivo)
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