Hepatitis B Community
Determination of reliability criteria for liver stiffness (fibroscan)
About This Community:

This forum is an un-mediated, patient-to-patient forum for questions and support regarding Hepatitis B. Topics in this forum include but are not limited to, Causes, Diagnosis, Family and Relationships, Living With Hepatitis B, Research Updates, Treatment, Success Stories, Support, Symptoms.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

Determination of reliability criteria for liver stiffness (fibroscan)

Determination of reliability criteria for liver stiffness evaluation in a cohort of 1165 patients

Background and aims: The manufacturer of Fibroscan has defined reliability criteria for liver stiffness evaluation (LSE): ≥10 valid shots with ≥60% success rate and IQR/median ratio (IQR/M) ≤30%. In the present study, we aimed at providing a first-ever assessment of the validity of these LSE reliability criteria. Methods: 1165 patients with chronic hepatitis, liver biopsy, and LSE by Fibroscan were included. Fibrosis classification (F0/1, F2/3, F4) was defined from LSE results according to diagnostic cut-offs published by Friedrich-Rust (Gastroenterology 2008). Results: Causes of chronic hepatitis were: viral hepatitis (76.3%), alcohol (12.6%), NAFLD (2.8%), and other (8.3%). 75.3% of LSEs were reliable according to the manufacturer’s criteria. AUROCs of significant fibrosis (F≥2), severe fibrosis (F≥3), and cirrhosis (F4) were not significantly different between reliable and unreliable LSEs, respectively: 0.836±0.014 vs 0.789±0.027 (p=0.122), 0.882±0.011 vs 0.857±0.023 (p=0.327), and 0.915±0.012 vs 0.906±0.021 (p=0.710). Significant fibrosis was independently associated with LSE result (1st step, p <10-3), age (2nd step, p <10-3), and IQR/M (3rd step, p=0.028). Severe fibrosis was independently associated with LSE result (1st step, p<10-3), IQR/M (2nd step, p=0.007), and age (3rd step, p=0.007). Cirrhosis was independently associated with LSE result (1st step, p <10-3), biopsy length (2nd step, p=10-3), and IQR/M (3rd step, p=0.011). AUROCs for significant fibrosis, severe fibrosis, and cirrhosis were significantly higher when IQR/M was ≤0.10. In LSE 0.30. In LSE >13.0kPa, the diagnostic accuracy significantly decreased when IQR/M was >0.10. 17.3% of patients had an IQR/M ≤0.10, 68.1% had 0.100.30. Conclusion: The Reliability criteria for LSE defined by the Fibroscan manufacturer are not relevant: the only parameter influencing LSE accuracy is IQR/M; number of valid shots and success rate had no influence. IQR/M defines 3 groups of LSE: “very reliable” when IQR/M is ≤0.10, especially in LSE >13 kPa; “reliable” when IQR/M is between 0.10 and 0.30; and “unreliable” when IQR/M is >0.30 in LSE ≥7.6kPa.
Related Discussions
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis B Community Resources
RSS Expert Activity
233488_tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488_tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543_tn?1371753642
Blank
TMJ/TMJ The Connection Between Teet...
Jan 27 by Hamidreza Nassery , DMD, FICOI, FAGDBlank
Top Hepatitis Answerers
Avatar_m_tn
Blank
stef2011
Italy
Avatar_m_tn
Blank
sorte
Other
Avatar_m_tn
Blank
StephenCastlecrag
Australia
Avatar_m_tn
Blank
mike9111
MI
9624973_tn?1413019730
Blank
melcul
United Kingdom
Avatar_m_tn
Blank
luckyman316