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Does it need treatment?
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Does it need treatment?

My husband has HBsAg reactive, HBeAg non reactive, and HBV DNA PCR positive (9.6x10^3 copies/mL) on June, 2008.
On March, 2009, HBsAG still reactive but it decrease. Does my husband need treatment or medicine? Is HBV DNA can be negative?How?Please if there are anyone can help.
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Avatar_m_tn
Does my husband need treatment or medicine?

--What is his ALT AST?

Is HBV DNA can be negative?

--With treatment it can be UND which is different from negative.
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Avatar_f_tn
I am sorry,but what is ALT AST? Is that the same with SGOT SGPT? Until now SGOT SGPT is still in normal level.
Can I know what treatment does you mean to change HBV DNA into UND? Is that mean that HBV DNA UND it doesnot infectious anymore?
Thank you very much..
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Avatar_m_tn
yes ALT and AST is the same thing as SGOT and SGPT..different measuring units but the same thing ..its what you call a liver panel

second question, becoming UND is an immediate but the ultimate goal. you can acheive UND while still postive to HBEAG  but once you turn negative on the E antigen then treatment may not be needed anymore.. some doctors will still have their patients go on treatment for another year or so after seroconverting from e postive to e negative but ultimately they stop the treatment and go on monitoring every 6-12 months
once you are noth E antigen negative and HBV DNA UND , you are considered less infectious but not NOT infectious anymore.. chance of infecting others becomes of a lessor percentage though ofcourse  it is there . after all you are a carrier of the virus and  giving it to someone else is a present possibility for as long as you have the virus in you.
there is no such  " not infectious anymore" in my opinion.. maybe your chances to infect someone else decrease but are always always always there..
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Avatar_m_tn
Agreed with bberry.

If ALT and AST normal, some doctors will monitor your husband rather than treat.

Many people make HBV DNA go UND by antiviral treatment.
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Avatar_f_tn
Thank you for your comments.
My husband has tested HBeAg negative/non reactive. Does it mean he doesn't need any treatment? Is there a chance that the HBV virus can be more dangerous and become cyrocis if the virus is still active and no treatment at all?
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Avatar_m_tn
Does it mean he doesn't need any treatment?

--Varies from doctor to doctor.

Is there a chance that the HBV virus can be more dangerous and become cyrocis if the virus is still active and no treatment at all?

--There is a chance but even with DNA becoming UND and HBsAg positive, there is still a  chance.
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Avatar_m_tn
Does it mean he doesn't need any treatment?

--Varies from doctor to doctor.

Is there a chance that the HBV virus can be more dangerous and become cyrocis if the virus is still active and no treatment at all?

--There is a chance but even with DNA becoming UND and HBsAg positive, there is still a  chance.
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Avatar_f_tn
So, if someone have been infected with HBV, it means that the virus will stay on his/her body forever? Isn't there any cure for hepatitis B? What should I do?
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