Cirrhosis is a major killer in the UK
A cheap and readily available drug could reverse severe liver disease, even in patients who find it impossible to give up booze, research suggests.
Sulfasalazine is currently used to treat arthritis and inflammatory bowel disease.
But a University of Newcastle team has found that it can also reverse the scarring associated with cirrhosis of the liver.
Liver disease is the fifth highest cause of death in the UK.
It would not be too optimistic to say this drug could halve that death rate
Professor Chris Day
It is estimated that up to 10% of the UK population have problems with their liver - and most are linked to lifestyle factors, such as heavy drinking and obesity.
Scientists had thought that the scarring associated with cirrhosis - known as fibrosis - was irreversible.
However, recent studies have shown that is not the case.
Now the Newcastle team, in tests on animals, have shown that sulfasalazine can aid the recovery process.
When the liver is injured specialised cells called hepatic myofibroblasts create scar tissue, and secrete proteins which prevent it being broken down.
In healthy liver tissue the scars eventually melt away and are replaced by new normal tissue.
However, in diseased tissue this process does not happen. Instead the scar tissue proliferates, and spreads throughout the whole organ.
The Newcastle team showed that sulfasalazine could aid recovery by blocking the production of proteins that keep the scar tissue cells alive.
They plan to carry out trials in humans, but already believe the drug has the potential to provide an alternative to a liver transplant.
The drug will initially be given to heavy drinkers who have given up alcohol, but too late for their liver to recover naturally.
If this proves successful, the medicine will also be prescribed to alcoholics who continue to drink but show a determination to fight their addiction by reducing their intake.
Professor Derek Mann, who led the research, said just a 5% to 10% recovery of the organ could have a huge impact on quality of life.
Professor Chris Day, head of Newcastle University's School of Clinical Medical Sciences, said the drug was likely to work best on people who had made some effort to kick their boozing habit.
But he said it offered a potential solution to the tricky ethical problem of offering people who abused alcohol a liver transplant.
Some believe it is wrong to use organs that are in very short supply on people who have not demonstrated their ability to reform their drinking.
Professor Day said: "In that situation you may not give somebody a transplant, but you are not going to stop them getting a tablet, particularly if it only costs £10 a week.
"Cirrhosis is the fifth highest cause of death in the UK today, and it would not be too optimistic to say this drug could halve that death rate."
Professor David Jones, another member of the Newcastle liver team, said he and his colleagues regularly saw patients in their twenties with severe liver disease.
He said: "There is no point at which an alcoholic patient won't benefit from stopping drinking, but now we can actually help the healing process."
Anne Jenkins, of the charity Alcohol Concern, said: "The last 20 years have seen a significant increase in rates of liver cirrhosis, particularly among the 34-45 age group.
"Research that could help to reverse harm is obviously to be welcomed, but this work is at an early stage, and more needs to be done."
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.