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Entecavir Ineffective in Patients with Lamivudine and Adefovir Drug Res...
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Entecavir Ineffective in Patients with Lamivudine and Adefovir Drug Resistance

we already know this from many years in this forum.why are some researchers so stupid to use these drugs while we know tenofovir makes no resistance.......tenofovir is cheaper this is the reason

Entecavir Ineffective in Patients with Lamivudine and Adefovir Drug Resistance
Researchers treated 33 patients with high HBV DNA levels—despite earlier treatment with lamivudine and the antiviral adefovir (Hepsera)—with entecavir to see if the drug would be effective against multi-drug-resistant HBV.

According to their report in the Journal of Viral Hepatitis, after 48 weeks of entecavir treatment 67% achieved normal ALT, and only 24% had undetectable HBV DNA.

After 96 weeks of entecavir, 79% had normal ALT levels, but only 17% had undetectable HBV DNA, showing that entecavir was ineffective in this drug-resistant group of patients.
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