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GcMAF and activation of macrofages

an italian well know researcher is making research on GcMAF with yamamoto.

of course if this work no drug maker will ever produce this drug and US will go bankruped

but we are lucky anyway because it is in everybodies blood like immune globulins, so no sides, no patentable, no high cost and especially no trials needed to check safety or for its use.if it works it would make US bankruped

http://www.gcmaf.org/

belgium production
http://www.gcmaf.eu/info/

israel production
http://pps.co.il/

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Avatar universal
it has reached the market from end 2010

recommened clinics
http://www.gcmaf.eu/info/index.php?option=com_content&view=article&id=122&Itemid=56

if you use the clinics you  will proably pay more so it is better to contact gcmaf.eu, they have a phone number contact too
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I just cant get a hold of them everytime they transfer me and dont get anybody on the phone.

Well it seems like we have to wait untill this thing hits the market.
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full article about gcmaf and level of healthy nagalsein serum
http://www.bgli.nl/documents/research/Immunotherapy_of_HIV-Infected_Patients_ith_Gc_Protein-Derived_Macrophage_Activating_Factor_(GcMAF).pdf

Healthy control sera exhibit very low levels (0.35–
0.68 nmol/min/mg) of the enzyme activity.
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Avatar universal

got the test today and checked lab.that is an ultra advanced lab mainly for service to clinics, healthcare systems, MDs worldwide.we lucky they accept single requests

they have superadvanced tests for oxidative stress, vitamins and elements in blood, as many of you might know the chemical assays for vitmains and elements are not good sensitivity, i have seen they have research level assays for this with the highest sensibility (they don t use the chemical assays)
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good luck :D
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good luck. keep us posted :D
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65usd, quite cheap, i suppose it is cheap because used on cancer/hiv studies related to gcmaf of course
3 weeks for resut
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how much money and time to take this nagalase check?

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i am also about to start it, tomorrow i will be in the netherlands for the nagalase check
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tomorrow i m gonna ring the research center here in belgium en ask some info regarding gcmaf

additional info shall be posted.
kind regards
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of course those not close to cirrhosis have nothing to worry about immune ystem activation but for those with severe liver damage it is better to act similarly as regards interferon with the less possible dmage to the liver
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you need to regress liver damage by tenofovir or entecavir first so that when immune system is activated the damage to liver will be less, it is better to have a low hbvdna starting this so that less liver cells are killed
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If so i will to be a part of this party
I hope it will be available soon.

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thanks :D
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http://forums.questioningaids.com/showthread.php?t=6631&page=12

check here
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i'm unable to view the link. which study is that?
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to all:

Here is a nice up to date presentation by Marco Ruggiero about GcMAF:

http://www.marcoruggiero.org/pdf/Col...for%20AIDS.pdf

so both gcmaf.eu and BLI.nl sources are perfectly ok, i am looking forwards to try this treatment as soon as possible, too bad i have to wait a couple of weeks for the nagalase test
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sorry meant:
but since they must be in dry ice pack
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for those who can:
test your nagalase level, it might show immune suppression and if present this explains cronic hbv

the test is not expensive, about 65euro, so we can understand how nagalase level correlates with hbv.blood samples can be sent at this laboratory but since they might be in dry ice pack the type of shipment must be fast

in europe:
http://www.europeanlaboratory.nl/

in US:
contact the lab for indications where to do it in US
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Avatar universal
If Hep only needs to be Quarantine and our human body just need to be healthy doest in mean that with the help of these kinds of drugs hep B can be eliminated? My doctor always reminds me to be healthy bec. sooner or later drugs is ready to all... It needs a deeper research and funds for that.... but who knows... may be tomorrow ....
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Avatar universal
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC39321/pdf/pnas01511-0079.pdf

The results of this study demonstrate that hepatocellular
HBV replication can be abolished by noncytopathic, cytokinedependent pathways activated by an unrelated viral infection
of the liver, even when that infection is principally limited to
a different cell type, in this case the macrophage. This suggests
that the induction of cytokine activity within the liver by agents
(viral or otherwise) that activate resident macrophages or
other cell types to produce these cytokines may have therapeutic value in chronic HBV infection.

so this should mean that if we activate macrophages hbv gets cleared without damage or relevant alt flares
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Avatar universal
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC39321/pdf/pnas01511-0079.pdf

i found this study that shows how hbv clearance is medited by macrophages without liver damage, if nagalase happens to be elevated during hbv infection macrophages are inactivated and this might be probably the reason and the key to get rid of hbv
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Avatar universal
"http://hbo-kennisbank.uvt.nl/cgi/av/show.cgi?fid=5022"

Very good paper by a PhD student. Immunology is so complex, so many inter-relationships, you need to be a full professor to understand it all. So many things can influence the immune system, where do you start? Good luck with Gcmaf.
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in conclusion the studies confirms that macrophages impairment (probably by hbv or by hbv increasing nagalse who knows...) and dentric cells impairment (dentric cells respond to macrophages that present hbsag) might be the reson of no immune response on cronic hbv

there is also a part which talks about macrophages and hbsag but i haven t got it clear, what i suppose is that activated macrophages by gcmaf express a lot of receptors, among those also TLR receptors, get hbsag (don tknow if single hbsg antigen is needed or all virus) and then present that to dentric cells which give permission to t cells specialized on hbsag to duplicate and make a lot of hbsab

the only fear in my hypothesis is if macrophges need the full virus to digest and present the single antigens to dentric cells or if even single hbsag are enough to start immune response
this would be a big problem on tenofovir or entecavir therapies, since both decrease circulating virions and so decrease immune response too even in the case of using gcmaf
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