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GcMAF and activation of macrofages
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GcMAF and activation of macrofages

an italian well know researcher is making research on GcMAF with yamamoto.

of course if this work no drug maker will ever produce this drug and US will go bankruped

but we are lucky anyway because it is in everybodies blood like immune globulins, so no sides, no patentable, no high cost and especially no trials needed to check safety or for its use.if it works it would make US bankruped

http://www.gcmaf.org/

belgium production
http://www.gcmaf.eu/info/

israel production
http://pps.co.il/

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http://www.gcmaf.co.uk/info/

sorry forgot to say name of the italian researcher, marco ruggeri in florence, he is often out of italy for work but i will try to talk to him next time i am in pisa for check up visit

i paid very much interest to this because marco ruggeri is very well known and serious researcher.i read some of his research and looks very balanced and also my doctors know him

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wow! i hope they test this on hepatitis patients. this looks promising.
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i got a response from GcMAF producers

I have heard a few physicians say that it is worth a try for Hep. in particular. We do not know if they have tried it yet.
The product works independently. It does not target a specific pathogen, it enhances the immune system, which then can take care of pathogens itself.
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they do supply it also for hbv but i'd use it only with a researcher although it has no sides
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Thank you Stefano for your research for cure.

Are you planning to use this substance to treat yourself? But, in the materials no mention about HBV, only HIV.

I am eager to this medicine workable for HBV.  It is much pain to family to bear this cruel disease.  

Is it expensive? Affordable to low income people?
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i haven t seen prices at about 600euro and free resend of drug if no cancer regression at all happens, the drug doesn t target a disease but immune system which is blocked by viruses and cancers, then it works on any disease with immune system block

i will talk to the italian researcher involved but i plan to use it only if alinia and interferon will fail
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http://www.marcoruggiero.org/pdf/GcMAF%20at%20the%20NIH.pdf

conclusion:
NF kappa suppress immune function and is induced by tumor carinogens and viral proteins of hiv,...other viruses....HBV,HCV

Gcmaf produces NF kappa inhibition, so definitely this therapy, FREE OF SIDES, less expensive than interferon, less expensive than baraclude worths a try

hbv carriers are also at increased risk of leukemia this is probably due to NF kappa


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www.marcoruggero.org
personal website of researcher marco ruggiero with GcMAF info  

usefull links from marco ruggiero website:

Biology at the University of Firenze
http://www1.unifi.it/clsbio/mdswitch.html

Research Institutions

National Institutes of Health degli Stati Uniti
www.nih.gov


National Cancer Institute

http://www.cancer.gov/


La ricerca del Pentagono (comprende la ricerca in biologia)

www.darpa.mil


L’Istituto di Craig Venter (vita sintetica, genoma del pianeta)

www.jcvi.org


Dall’Università dello Utah un sito eccellente e gratuito per la didattica in biologia cellulare, molecolare e genetica. Esperimenti virtuali e dimostrazioni interattive

http://learn.genetics.utah.edu/



Database

www.pubmed.com

http://library.med.utah.edu/WebPath/HISTHTML/HISTO.html
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www.marcoruggero.org
personal website of researcher marco ruggiero with GcMAF info  

usefull links from marco ruggiero website:

Biology at the University of Firenze
http://www1.unifi.it/clsbio/mdswitch.html

Research Institutions

National Institutes of Health degli Stati Uniti
www.nih.gov


National Cancer Institute

http://www.cancer.gov/


La ricerca del Pentagono (comprende la ricerca in biologia)

www.darpa.mil


L’Istituto di Craig Venter (vita sintetica, genoma del pianeta)

www.jcvi.org


Dall’Università dello Utah un sito eccellente e gratuito per la didattica in biologia cellulare, molecolare e genetica. Esperimenti virtuali e dimostrazioni interattive

http://learn.genetics.utah.edu/



Database

www.pubmed.com

http://library.med.utah.edu/WebPath/HISTHTML/HISTO.html
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http://www.diagnosesupport.com/info/index.php?option=com_content&view=category&layout=blog&id=8&Itemid=9
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a lot of studies available at this page

http://www.diagnosesupport.com/info/index.php?option=com_content&view=category&layout=blog&id=6&Itemid=2
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i don t understand,
is Nagalase activity increased for all the cases of cronic (chronic) cancers and viruses that have immune system blocked?
if so can we test our nagalase activity and our receptors poliymorphisms to see if GcMAF can have a great response on us?
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http://forums.aboutmecfs.org/showthread.php?6019-GcMAF-for-XMRV-Gc-protein-derived-macrophage-activating-factor-anyone-taking-it

this is a thread in a cronic (chronic) fatigue syndrom (syndrome) forum, they are treating with GcMaf already from 2010 under specialized doctors.it might be useful to see their experiences although this drug might not be effective for them, unluckily CFS has unknow probably viral origin

i see they have reference labs for testing but i think in hbv infection it is not needed, hbsag quantification and all antigens/antibodies quantification might be good enough, while hbvdna and alt must not be considered as a tool to see immune system reaction.
mainly hbsag and hbsab can be used to see that

it is lo menthioned that vitamin d levels must be normal for GcMaf to work
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http://forums.aboutmecfs.org/showthread.php?6019-GcMAF-for-XMRV-Gc-protein-derived-macrophage-activating-factor-anyone-taking-it/page55

somebody used it to clear hcv successfully, i ll try to get in contact with him.in this post there is indication also about best producer.
drug available in europe while US the most difficult place where to take it...(guess what drug companies making issues)

dsp2011  
Junior Member
Join Date
Dec 2010
Posts
5

Just spent hours reading entire tread.

1. Why no one is testing vitamin D3? This is what GcMaf supposed to use to work off, right? So why are you guys running bunch of utopia tests and forget about this one? I can't believe your GcMaf rep didn't tell you to make sure you tan or have enough vitamin D3 in your blood before you start. No vitamin D3 - no macrophages meaning waste of GcMaf...
2. BGLI and any GcMaf that you need to freeze - is not original or real. it may work may not but not original formula. Original formla supposedto be refrigirated at 4-8 celsius and very stable - should be in great shape after 6month and even longer.
3. If you are paying less than $700 a shot you don't have original formula.
4. PPS in isreal is the company that produces it. they don't sell it directly but they do have representatives http://www.pps.co.il
5. Shipping to USA out of question. Ship it to Canada or Mexico to your friends and then pick it up and bring it over the border or fly to Israel or London - they can ship it to london address.
6. GcMaf has side effects, if you don't have any ***** to be you - you are using fake version and wasting money.
7. Friend of mine had great results with HEP C - negative after 8 years of being positive. he took 24 shots.

I don't have any updates on my situation because i just took my first shot and other than a lot of heavy side effects i can't report on anything but will let you know the progress once i have blood work and see numbers, i just hope i will turn out as good as friend of mine! so i keep my fingers and toes crossed :)
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Thanks very much for all the references - will put my reading glasses on and start reading.
These immune modulating substances cover a big big field. So far it seems:
1.IL-7 deals with T Cells
2.GcMaf deals with macrophages
Then there are Natural killer cells (NK), Dendrite cells, innate/adapted, humoral/cellular.....
[hope I got it right]
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thank you that's a big help from you because i might miss details sometimes since english is not my mother toungue

i try to read most of cronic (chronic) fatigue forum posts till late at night to see their experience on sides effects, producers of drug and so on
again i stress we cannot compare their weak/medium results because Gcmaf is not the answer to their disease but might help them find a balance, who knows exactly all the mess of viruses and immune system damage they have

today i will send an email to doctor ruggero to see if they studied anything on hbv too
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yes you are right about il7, the researchers in pisa know doctor andreone who makes italian tiral but they told me last year that there are too many risks for il7 especially because other trilas had severe immunological impairments which came out years after the trial

they say better stay here and watch carefully what happens...
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Interesting
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http://www.springerlink.com/content/2186446772066150/


ORIGINAL ARTICLE
Gc protein-derived macrophage-activating factor (GcMAF) stimulates cAMP formation in human mononuclear cells and inhibits angiogenesis in chick embryo chorionallantoic membrane assay
Stefania Pacini, Gabriele Morucci, Tiziana Punzi, Massimo Gulisano and Marco Ruggiero
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http://forums.aboutmecfs.org/showthread.php?6019-GcMAF-for-XMRV-Gc-protein-derived-macrophage-activating-factor-anyone-taking-it/page55

after some troll posts the forum talking about gcmaf has dissapered since 2 days....how strange, you are very good with google are you able to find back this forum?

one researcher in US who was making the gcmaf dyed some years ago and everything was stopped in US research of gcmaf..., are these two coincidences?

i always think for the worst things but anyway where we see something not welcome from drug makers it surely is good to give it a try
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Found this at:
http://******.***.com/index.php?topic=33634.0

It seems Ruggiero & Dr Nabuto Yamamoto (USA) are both controversial according to the following posts.

Posts: 14




Controversial Poster Thursday at Vienna Conference:GcMAF
« on: July 20, 2010, 07:10:07 am »

Let us know what you think. Use the new "Reactions" vote at the end of each post, below. Just click the 'Good' or 'Bad' box. (Added July 19, 2010).

July 17, 2010Controversial Poster Thursday at Vienna Conference: Call for Information on GcMAF
by John S. James

We will not be at the big Vienna conference starting tomorrow (International AIDS Conference, July 18-23), and would like to hear from anyone with a scientific background who can visit the poster below, on Thursday, and the presenter.

A separate paper published last year by N. Yamamoto and others (see the abstract and link to full text at http://www.ncbi.nlm.nih.gov/pubmed/19031451) claims to have cured 15 patients in Japan. "In the present study GcMAF therapy was given to nonanemic HIV-infected patients and found to be highly curative."

About 130 peer-reviewed papers related to this work can be found at http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=link&linkname=pubmed_pubmed&uid=19031451. The proposed mechanism seems plausible -- that HIV produces a substance that shuts down immune responses in monocytes and macrophages, helping HIV infection to continue. The treatment appears to restore the response.

The research is controversial because it claims to have cured HIV infection, and also prostate cancer. The connection is not outlandish, however; for example, U.S.-government funded research at Yale is looking at a possible immune-based potential treatment for the same two illnesses (http://opa.yale.edu/news/article.aspx?id=7061).

Also controversial, the poster presenter at the International AIDS Conference, M. Ruggiero, is an accomplished molecular biologist -- but also a leading HIV denialist (Google: "Marco Ruggiero" HIV -- or see his 14-minute lecture uploaded January, 2010, to http://www.youtube.com/watch?v=-Sh03lqTsJw -- or see the abstracts of the denialist conference being held in Vienna on the two days before the International AIDS Conference there, http://www.science-and-aids.org/e/abstracts.html). However, Dr. Yamamoto is clearly not a denialist -- and apparently has not published with Dr. Ruggiero before the Vienna conference starting Sunday.

There are lots of mysteries here. For example, how has Dr. Yamamoto been publishing this HIV work extensively for at least 15 years in peer-reviewed journals, recently reporting excellent results, with almost no attention from most other HIV researchers?

We are concerned because we have heard that funders of research are not seeing new ideas for curing HIV being proposed. But there are lots of ideas, some credible, and no way to know in advance which ones will work out. Many human groups close themselves off and become increasingly narrow in focus, until they are irrelevant. In that case, new ideas cannot come forward. It would be tragic is this is happening in AIDS.

Here is the reference to the poster on Thursday:

THPE00 51 Gc protein-derived macrophage activating factor (GcMAF) stimulates activation and proliferation of human circulating monocytes
M. Ruggiero (Italy), S. Pacini (Italy), N. Yamamoto (United States)
Program of the XVIII International AIDS Conference, July 18-23, 2010, Vienna, Austria, page 306; Thursday July 22.
http://aidsnews.blogspot.com/2010/07/controversial-poster-thursday-at-vienna.html


Gc PROTEIN-DERIVED MACROPHAGE ACTIVATING FACTOR (GcMAF) STIMULATES
ACTIVATION AND PROLIFERATION OF HUMAN CIRCULATING MONOCYTES
M. Ruggiero*, S. Pacini**, N. Yamamoto§
*Department of Experimental Pathology and Oncology, University of Firenze, Italy
**Department of Anatomy, Histology and Forensic Medicine, University of Firenze, Italy
§Division of Molecular Immunology and Immunotherapy, Socrates Institute for Therapeutic Immunology, Philadelphia, PA, USA
http://pag.aids2010.org/PAG/EPosterHandler.axd?aid=6536
« Last Edit: July 20, 2010, 07:19:12 am by Bobitalia » Logged
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Re: Controversial Poster Thursday at Vienna Conference:GcMAF
« Reply #1 on: July 20, 2010, 11:30:51 am »

How interesting.  I have to wonder why anyone who co-author something with Ruggiero who is at best a crackpot and at worst...scum of the Earth.
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Re: Controversial Poster Thursday at Vienna Conference:GcMAF
« Reply #2 on: July 27, 2010, 01:27:45 am »

There are a few things that would make me a bit skeptical here, aside from Dr Yamamoto's association with Ruggiero.

Firstly, Dr Nabuto Yamamoto is 85 years old.*

Secondly, his position is listed as "Division of Molecular Immunology and Immunotherapy, Socrates Institute for Therapeutic Immunology".

The address given for this Institute appears to be a private dwelling in suburban Philadelphia. The Institute has no website of its own. It is registered as a non-profit organization, and has no paid employees.

Internal Revenue Returns (Return of Organization Exempt From Income Tax) show little evidence of much actual research work over the past few years - no more than a few hundred dollars in expenses per year. By far the largest expense incurred by the Institute is "publication costs" in several medical journals.

http://nccsdataweb.urban.org/PubApps/showVals.php?ein=232834414

*I wonder if there has been some confusion with Dr Naoki Yamamoto who is the Director of the HIV/AIDS research center of the National Institute of Infectious Diseases in Tokyo.
« Last Edit: July 27, 2010, 02:25:28 am by Snout »
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the forum has got back online
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MD, PhD
Full Professor of Molecular Biology
Clinical Radiologist
University of Firenze, Italy

Department of Experimental Pathology and Oncology, University of Firenze,
Viale Morgagni 50, 50134 Firenze, Italy.

he is not a stupid doctor and considered a vey good researcher here in italy.
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No-one says he is a stupid doctor, it is his view on HIV/AIDS. Watch the video. Yamamoto needs investigating.
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http://www.marcoruggiero.org/pdf/From%20Coley's%20vaccine%20to%20GcMAF%202.pdf

very good presentation of overall studies on gcmaf, in a few weeks i'll go make nagalase test, it will require about 3 weeks for results

nagalase is very important for me both for hbv and cirrhosis nodules (on studies it regressed mouse liver cancer too) so according to nagalase results and researchers opinion i might try gcmaf before interferon+etv+alinia

wether gcmaf has an effect on hbv infection and the nodules or no effect i guess it is better to have immune system working better before interferon try.

if nagalase is within healthy levels i'll go directly for the interferon trial combo thatshould start end of april/june
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http://hbo-kennisbank.uvt.nl/cgi/av/show.cgi?fid=5022

study that shows how cronic (chronic) hbv has no immune response and suppression of macrophages, this confirms that gcmaf might have a role and justifies a try, so wether it can work or not it is good to combo it with other approved therapies especially interferon

i'll carefully read it fully later today
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this is very interesting...TLR is expressed on activated macrophages and activation of TLR is reported to clear hbsag, also the experimental gilead drug which clears hbeag activates TLR
TLRs are inactivated on cronic (chronic) hbv

The adaptive immune response is initiated and regulated by the innate immune system. The fastacting
innate immune system is characteristic in the lack of specificity and memory. The detection of
an invading pathogen occurs via pattern-recognition receptors (PRRs), such as Toll like receptors
(TLR) and C-type lectins, which are particularly expressed by DCs and macrophages. The receptors
are present at the cell surface and in the cytoplasm and/or in intracellular compartments, such as in
the endosomes [16].
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conclusion

Weak antiviral B and T cell responses are believed to be responsible for the lack of virus control in
chronic HBV patients [5]. The mechanism behind this immunological failure is still not understood. In
sharp contrast to other viruses, chimpanzees as well as human individuals infected with HBV showed
a complete lack in the induction of type I IFN and in IFN-response genes during the early stages of
infection [60, 61] , indicating a lack of activation of the innate immune system. The lack of effective HBVspecific
immunity could be due to inadequate activation of innate immune cells, but may also be due
to active immune modulation. It is recently observed that several viruses escape immunity via
targeting DC and Møs functions. For example, Vaccinia, Hepatitis C virus (HCV), Human
Immunodeficiency Virus (HIV) and measles virus infections are associated with impaired macrophage
and DC function [5, 62-67]
Here we report that HBV is not a strong inducer of innate immune responses. DC and Møs were not or
only weakly activated by HBV, resulting in marginal immune stimulating effects with respect to
cytokine production and NK cell activation. Immune suppressive effects of HBV were hardly observed.
Only in a few experiments/donors HBV reduced the production of pro-inflammatory cytokines by Mø1,
whereas Mø2 showed a reduction in both anti- and pro-inflammatory cytokines
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in conclusion the studies confirms that macrophages impairment (probably by hbv or by hbv increasing nagalse who knows...) and dentric cells impairment (dentric cells respond to macrophages that present hbsag) might be the reson of no immune response on cronic (chronic) hbv

there is also a part which talks about macrophages and hbsag but i haven t got it clear, what i suppose is that activated macrophages by gcmaf express a lot of receptors, among those also TLR receptors, get hbsag (don tknow if single hbsg antigen is needed or all virus) and then present that to dentric cells which give permission to t cells specialized on hbsag to duplicate and make a lot of hbsab

the only fear in my hypothesis is if macrophges need the full virus to digest and present the single antigens to dentric cells or if even single hbsag are enough to start immune response
this would be a big problem on tenofovir or entecavir therapies, since both decrease circulating virions and so decrease immune response too even in the case of using gcmaf
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"http://hbo-kennisbank.uvt.nl/cgi/av/show.cgi?fid=5022"

Very good paper by a PhD student. Immunology is so complex, so many inter-relationships, you need to be a full professor to understand it all. So many things can influence the immune system, where do you start? Good luck with Gcmaf.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC39321/pdf/pnas01511-0079.pdf

i found this study that shows how hbv clearance is medited by macrophages without liver damage, if nagalase happens to be elevated during hbv infection macrophages are inactivated and this might be probably the reason and the key to get rid of hbv
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC39321/pdf/pnas01511-0079.pdf

The results of this study demonstrate that hepatocellular
HBV replication can be abolished by noncytopathic, cytokinedependent pathways activated by an unrelated viral infection
of the liver, even when that infection is principally limited to
a different cell type, in this case the macrophage. This suggests
that the induction of cytokine activity within the liver by agents
(viral or otherwise) that activate resident macrophages or
other cell types to produce these cytokines may have therapeutic value in chronic HBV infection.

so this should mean that if we activate macrophages hbv gets cleared without damage or relevant alt flares
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If Hep only needs to be Quarantine and our human body just need to be healthy doest in mean that with the help of these kinds of drugs hep B can be eliminated? My doctor always reminds me to be healthy bec. sooner or later drugs is ready to all... It needs a deeper research and funds for that.... but who knows... may be tomorrow ....
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for those who can:
test your nagalase level, it might show immune suppression and if present this explains cronic (chronic) hbv

the test is not expensive, about 65euro, so we can understand how nagalase level correlates with hbv.blood samples can be sent at this laboratory but since they might be in dry ice pack the type of shipment must be fast

in europe:
http://www.europeanlaboratory.nl/

in US:
contact the lab for indications where to do it in US
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sorry meant:
but since they must be in dry ice pack
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to all:

Here is a nice up to date presentation by Marco Ruggiero about GcMAF:

http://www.marcoruggiero.org/pdf/Col...for%20AIDS.pdf

so both gcmaf.eu and BLI.nl sources are perfectly ok, i am looking forwards to try this treatment as soon as possible, too bad i have to wait a couple of weeks for the nagalase test
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i'm unable to view the link. which study is that?
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http://forums.questioningaids.com/showthread.php?t=6631&page=12

check here
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thanks :D
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If so i will to be a part of this party
I hope it will be available soon.

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you need to regress liver damage by tenofovir or entecavir first so that when immune system is activated the damage to liver will be less, it is better to have a low hbvdna starting this so that less liver cells are killed
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Avatar_m_tn

of course those not close to cirrhosis have nothing to worry about immune ystem activation but for those with severe liver damage it is better to act similarly as regards interferon with the less possible dmage to the liver
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tomorrow i m gonna ring the research center here in belgium en ask some info regarding gcmaf

additional info shall be posted.
kind regards
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i am also about to start it, tomorrow i will be in the netherlands for the nagalase check
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how much money and time to take this nagalase check?

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65usd, quite cheap, i suppose it is cheap because used on cancer/hiv studies related to gcmaf of course
3 weeks for resut
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good luck. keep us posted :D
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good luck :D
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got the test today and checked lab.that is an ultra advanced lab mainly for service to clinics, healthcare systems, MDs worldwide.we lucky they accept single requests

they have superadvanced tests for oxidative stress, vitamins and elements in blood, as many of you might know the chemical assays for vitmains and elements are not good sensitivity, i have seen they have research level assays for this with the highest sensibility (they don t use the chemical assays)
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full article about gcmaf and level of healthy nagalsein serum
http://www.bgli.nl/documents/research/Immunotherapy_of_HIV-Infected_Patients_ith_Gc_Protein-Derived_Macrophage_Activating_Factor_(GcMAF).pdf

Healthy control sera exhibit very low levels (0.35–
0.68 nmol/min/mg) of the enzyme activity.
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I just cant get a hold of them everytime they transfer me and dont get anybody on the phone.

Well it seems like we have to wait untill this thing hits the market.
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it has reached the market from end 2010

recommened clinics
http://www.gcmaf.eu/info/index.php?option=com_content&view=article&id=122&Itemid=56

if you use the clinics you  will proably pay more so it is better to contact gcmaf.eu, they have a phone number contact too
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