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Genotype and Mutation Questions
Are mutations of hepatitis b transferred from mother to son?
Yes, he should have actually been tested at 9 months (3 months after his last HBV series of 3 shots total). He needs to be tested for hbsag, anti-HBc, and hbsab. A booster or a whole 2nd series is not needed unless he is not positive for hbsab. Please do this asap by his Pediatrician or family doctor that usually sees him when he gets sick.
If that doctor is clueless just give him those 3 tests that I pointed out and tell him/her he needs them due to your family history of HBV. In the US family doctors and Pediatricians are very clueless and so I've learned to be an advocate and I tell them what they need to do regarding HBV. Good luck!
If that doctor is clueless just give him those 3 tests that I pointed out and tell him/her he needs them due to your family history of HBV. In the US family doctors and Pediatricians are very clueless and so I've learned to be an advocate and I tell them what they need to do regarding HBV. Good luck!
My son is 15 months old but has not been tested yet. I was wondering if it is a good time to test now. I was thinking of adding a booster shot regardless at age 2. I wonder if that would be a good idea. I will talk to my hep doc and see.
Sorry I was unclear he got his first shot within 3 hours and finished all by 6 months. Do most hbeag - genotype c have bcp / pc mutations. Its bad to have one, but to have both is =/
Mutations can transfer, from my understanding.
How come your baby received the HBIG shot at around 6 months? It should of been given at birth if you are a carrier, that's when transmission is likely. My hepatalogist said the likelihood of tranfering from day to day is extremely low, so don't worry now.
If your baby got HBIG before six months, I am assuming your baby also got his first shot of vaccinations? If so, by now, your baby should of gotten all three shots and can be tested for antibodies. Once you test them for antibodies, and they are positive, there should be nothing to worry about.
How come your baby received the HBIG shot at around 6 months? It should of been given at birth if you are a carrier, that's when transmission is likely. My hepatalogist said the likelihood of tranfering from day to day is extremely low, so don't worry now.
If your baby got HBIG before six months, I am assuming your baby also got his first shot of vaccinations? If so, by now, your baby should of gotten all three shots and can be tested for antibodies. Once you test them for antibodies, and they are positive, there should be nothing to worry about.
Some mutations are due to the virus trying to escape from the body trying to fight it off and others are created by low resistant antivirals. Since HBV is so crafty and involves ones immune system and virus reaction I do believe different mutations can exist within family members, but do not know the extent or how common this is. I also believe the basal and precore to be more common that others, but do not know if it is rare to have both. Maybe some of the more experienced on here will be able to help with those good questions.
As for the antibodies and my son....yes I have a now 15 year old son who got the HBIG shot soon after birth and received the full series. When he was 9 months old he was tested and was hbsag negative, core negative, and hbsab negative (my other 2 kids at this time were negative for all except their hbsab was positive). We gave him the series again and he finally got hbsab positive, around 2 years old. Fast forward a few months ago. I asked doctor if my kids needed boosters and she didn't know so she tested their titers. All 3 kids were still hbsag negative, core negative, but this time hbsab negative. She was totally confused and freaked me out. We ended up giving a booster and then going to a specialist for them (I think all for nothing now). A month after booster they all got their hbsab positive again.
Has your son been tested for hbsag, anti-HBc (core), and hbsab? There is no worry for you if your son is negative to hbsag, negative anti-HBc, but positive to hbsab.
As for the antibodies and my son....yes I have a now 15 year old son who got the HBIG shot soon after birth and received the full series. When he was 9 months old he was tested and was hbsag negative, core negative, and hbsab negative (my other 2 kids at this time were negative for all except their hbsab was positive). We gave him the series again and he finally got hbsab positive, around 2 years old. Fast forward a few months ago. I asked doctor if my kids needed boosters and she didn't know so she tested their titers. All 3 kids were still hbsag negative, core negative, but this time hbsab negative. She was totally confused and freaked me out. We ended up giving a booster and then going to a specialist for them (I think all for nothing now). A month after booster they all got their hbsab positive again.
Has your son been tested for hbsag, anti-HBc (core), and hbsab? There is no worry for you if your son is negative to hbsag, negative anti-HBc, but positive to hbsab.
Is it rare to have both those mutations. After checking different research papers on google, it seems many people have one or the other. Can my own body create diff mutations that my other family members did not have? I also notice one of your post about how you were worried about your childs antibodies to hep b. I have a 15 month old and also very worried. He had his HBIG before 6 months, but now with a viral load going up, living in the same house hold and having genotype c double mutation, I worry for him. I hate to have him have these issues that I am going through.
I do believe if your mom had certain mutations and then transferred HBV to you the mutations (and genotype) transfer.
The virus/immune system reaction can also make new mutations along the way. So, your mom may or may not have the same as you, if you've made new ones. Your mutations are common in escape hbeag negative viral load above 2,000 iu/ml, genotype C (taken from your other post data).
The virus/immune system reaction can also make new mutations along the way. So, your mom may or may not have the same as you, if you've made new ones. Your mutations are common in escape hbeag negative viral load above 2,000 iu/ml, genotype C (taken from your other post data).
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