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HBIG?
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HBIG?

If a child is born to a HBsAG+ mother and didn't receive the HBIG at birth but did receeive the 1st vaccine, can the child still be protected from getting the virus?
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Avatar_m_tn

the infection might happen thru placenta too and there is a small percentage that doesn t respond to vaccine or gets hbsag mutant or occult hbv

make sure abbott architect is used for hbsag and hbsab tests, it detects almost all hbsag mutants, if hbsag gets negative, hbsab positive with high titer, hbvdna undetactable the vaccine worked.just remake these tests at 5 and 10 years for maximum safety
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Avatar_m_tn

yes he can be protected anyway.you must check hbsag, hbsab, hbcab and hbvdna pcr if all tests are free or cost is not a concern

if hbeag was negative and hbvdna undetactable/very low or very low possibily of infection is extremely low.about 5 to 10% dont respond to vaccine or get occult hbv when hbeag is positive or hbvdna high

there is possibility of infection and occult hbv infection but this is extremely rare, occult hbv infection can be found only with hi sensibility pcr hbvdna (6-12iu/ml sensibility) and it is better to recheck at 5 and 10 years old
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Avatar_f_tn
Is there a way to test the child to see is they were vaccinated with HBIG?
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Avatar_m_tn

no, but hbig is not so important and carry an extremely low and rare danger which is not zero danger
since it is blood extracted from people who has developped hbsab antibody it might carry hbsag mutants and occult hbv, infact a very low percentage of babies gets occult hbv but it is not yet known if from hbig

vaccine is the most important and mother with hbeag negative

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Avatar_f_tn
What if the mom is hbeag positive?
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Avatar_m_tn

the infection might happen thru placenta too and there is a small percentage that doesn t respond to vaccine or gets hbsag mutant or occult hbv

make sure abbott architect is used for hbsag and hbsab tests, it detects almost all hbsag mutants, if hbsag gets negative, hbsab positive with high titer, hbvdna undetactable the vaccine worked.just remake these tests at 5 and 10 years for maximum safety
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Avatar_f_tn
What exactly is occult HBV or an HBsAG mutant?
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