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HBSAg & HBV DNA Quantitaive PCR relation

Hi Guys

I am facing HBSAg +ve since 2000 when i was 15 years, now i m 27.
Following are my results.

HBSag Cut off: 1      Patient: 3393
HBeAG: Non Reactive
Anti Hbe: Reactive
ALT: 29
ASt: 26

HBV DNA PCR Quantitative: 1114 IU/ML & 3799 copies per ML

I have these questions:

1- Do HBSAg patient value and HVB DNA PCR value has any relation, as those values look close?
2- What are the units of HBSAg result? is it IU/ML?
3- I have inactive carrier as my PCR value is <2000, is it possible to have HBSAg negative??
4- What does HBSAg value exactly means?

thanks a lot
Best Answer
Avatar universal
Note: your HBSAg not quantitative tests! (value that you see are the reaction valuse and not the quantity value - for a quantitative tests you should recive a value in  IU/ml )

1 - this is still under research and debate among doctors
2 - IU/ml - but as I mentioned your value are most likely the qualitative and not quantitative
3 - natural seroconversion s is 1 - 2 % per year. note that inactive carrier definition is also under research debate, some of researchers introduce also qHBsAg in this equation beside HVB DNA.
4 - not clear for me
3 Responses
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Avatar universal

we posted many articles explaning hbsag, it is very long so better you search community

said very short it reflects virus infected cells in hbeag pos, virus suppression of our immune system on both hbeag pos and neg, total transactionl activity of cccdna on hbeag neg
Helpful - 0
Avatar universal

you can easily see when it is qualitative because it has a cut off value 1

quantitative has lower limit of detection 0.05iu/ml
Helpful - 0
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