HBV DNA 10,274 IU/ML , stefano cajim plz suggest

[hbv]

I am from pakistan (South East Asian). 6 months ago during a medical exam it was discovered that i have HBV.
Reports are given below with dates.
- 14 Jan 2010 :- HBSAG --- Reactive ( > 250.0 ) -- Cutoff rate is 1.0
                    Hepatitis C Antibody -- Non Reactive -- Cutoff rate is 1.0

- 4 Feb 2010:-Hepatitis Be Antigen -- Non Reactive -- Cutoff rate is 1.0
                    Hepatitis Be Antibody - Reactive ( 0.02 ) -- Cutoff rate is 1.0
                    Hepatitis Delta Antibody -- Non Reactive
                    Gamma GT 16 IU/L ----- ( 3-50 )
                    SGPT ( ALT ) 21 IU/L ........ ( 0 - 55 )
                    Total Protein  8.2 g/dl ......... ( 6.7 - 8.2 )
                    Albumin         4.7 g/dl ......... ( 3.2 - 5.5 )
                    Globulin         3.5 g/dl ........  ( 1.8 - 3.2 )
                    A/G Ratio       1.3 ........     ( 1.1 - 2.4 )
                    SGOT (AST)   30 IU/L .........( 8 - 46 )
                    P.T .............. 12.3 Seconds ............ ( 9-14 )
                    P.T Control ......... 11.0 Seconds
                    I.N.R  .................. 1.17 Ratio

07 Jun 2010 :-
                     HBSAB .......... Non Reactive ( 2.00 ) mIU/ml
                     HBeAG .......... Non Reactive
                     HBeAB ...........Reactive
                     SGPT ( ALT ) .... 13 IU/L
                     SGOT ( AST ) ..... 28 IU/L

21 July 2010 :-
                    Hepatitis B Viral Load ( Quantitative )  ---- 10, 274 IU/ml
Test Principle : This assay exploits the principle of real time fluorescence PCR. The increase in fluorescence is directly proportional to specific target amplification during PCR.  

Any feedback from all the experts much appreciated.                    

                

[hepbvictim]

Where is Cajim gobe? He is not replying nowadays..

[stef2011]

genotype is another test but it is not very important, we know loss of hbsag with tenofovir and entecavir happens on genotype A and D, interferon is less potent on genotype D, mixed genotypes are very dangerous (multiple infections from infected with different genotypes)

be sure hbsag is in iu/ml,

hbsag test in s/n is not very useful because s/n since there are diluitions usually so if a different diluition is used you don t understand if decreasing

you will be lower than 7kpa for sure....hope you are confirmed inactive and you can start nitazoxanide

[hbv]

Excellent.....Fibroscan machine is also started this month. I am thankful to God. I will Fibroscan on next month and will post the result here. Hope for the best.

[hbv]

It's a good news for me that hbsag Quantitative test has been started this month in a well reputed hospital here, my Dr. Told this. I will first take hbsag test then post here. Also please tell me how to know the genotype. I forgot to ask this question to my dr. Do this require another test ? I don't know about s/n unit which you have mention, could you please elaborate it.

[stef2011]

it is off label so even if drug has very very mild sides (so mild that we say no sides) it is up to doc
a member of the community has found a doc who prescribed it on hbv, on hcv docs and some insurance companies are covering

in any case the best is to order online to secure pharmacy or buy it at lupin distributors in US, nizonide500 by lupin is the cheapest.
you have to look for generic not alinia, alinia will cost about 3000usd per month on the 2g per day.if you are close to mexico you can buy daxon there which is licenced by romark but again daxon is more expensive than nizonide500.

as to europe i have never heard of any generic here, they use romark brand but as i said earlier it is too expensive.In italy nitazoxanide is not registered at all and i guess europe is the same (diarrea s rare here and more common in third world countries especially on aids patients so the drug is very easy to find there)

[almaja]

Dr. in US are not proscribing alinia I think I am good candidate for thet, what you sugest i shuld do, i am going to eurepe next summer (if i stay helthy)can i get it there?

[stef2011]

i'd go directly for ntz 1.5-2g daily and see if hbsag and hbvdna decrease, if they don t within 3 months i'd just monitor and wait for drugs effective on hbv

it is very important that you check hbsag it is the first to go down, also test with s/n unit is ok it will not tell us your hbsag quantity but will tell us if decreasing or steady.i'd not go for biopsy since your liver is working perfectly and ntz has no sides or risks when you stop it, it will just relapse to baseline levels if it doesn t work

[hbv]

I have visited to the Dr. he told me (based on my viral load ) that if ALT/AST will normal again then he will give me two options, either go to biospy or watch and see ALT/AST. I also discussed about Ntz , he told me there are more drugs in pipeline and hope so if ntz passed all trials then it will be available in market after 4-5 years. He also asked to take two tests in next visit, SGOT/SGPT & HIV 1&2 antibodies.
He also told me that he will not start medicine unless and until elevated ALT/AST and abnormal liver reports ( after biospy ). I don't wanted to waste my money in biospy as it's not cheap. Please suggest do i have to go for his options or go to mine. I.e starting ntz asap. I don't have any symptoms yet. May be i would like to save money for medicines.

[stef2011]

If hbsag becomes UND for long, will it means cure ?

this is the process of cronic hbv, hbsag is produced in large numbers not needed by virus, the quantity is so high that the antibody hbsab cannot netraulazie it, immune system T cell suicide them selves because of this high hbsag and the antibody never appear,
if hbsag gets negative the antibody appear and immune control of hbv is achieved, hbv will never come back

no sides, only mild diarrea, make baseline hbsag quantity in iu/ml and hbv dna pcr before you start and then check after 4,8, 24weeks and then yearly or every 6 months

i'd try it 6-12 months not more, it acts different from antivirals it henance immune system response, no resistance so you can stop if it doesn t work

[hbv]

If hbsag becomes UND for long, will it means cure ? or i have to even monitor for years.
Is it the website of lupin, if i am not wrong http://www.**********.***/***********.htm

What are the sideeffects of alinia and after how many days i have to test in lab. May i left it if it not work over me during the treatment.  

[stef2011]

if you choose to start alinia lease update progress here on the community or even better join our group by sending a PM to me

[stef2011]

it is better to have tests first so you know it is alinia if hbvdna gets und immediately and hbsag gets lower, just to be sure 100% it will work on you

hbsag quantitative in iu/ml is a new test for countries not up to date with hbv research, maybe it is difficult to find there

nizonide500 from lupin is ok the purity is 99.9655%, for 100% maybe romark or daxon in mexico but these are very expensive and maybe the same purity as lupin because the minimum requirement is 99% so i don t think they use the 100% form even in US or mexico
as to the curative effect 99,9655% or 100% makes no difference

[hbv]

Sorry i forgot to mention my age, i am 30 years of age male. I am slim just 56 Kg weight. Do i need to lower the HBV DNA to UND first ? or have to test HbSAG Quantitative. Actually the tests are expensive here. So i wan'a go to the right direction. Also specialize Dr. are not fully aware about latest development in Hepatitis. I don't want that they just misguide me.

I have visited to the laboratory for inquiry about Surface Antigen Quantitative test but it was surprise that they just said they have arrangement of only for HBV DNA. I will visit more laboratory soon.

We have border close to India, if you know the exact name of pharmacy then share the name, here some local pharmacy can arrange it for me. But how can i check that it's the purest form of Alinia. Can you give me an idea and pricing information for India. Or Do i directly buy it from somewhere else.  

[stef2011]

you are inactive just monitor or try alinia, if possible check also hbsag quantity by abbott architet hbsag quantification in iu/ml, if lower than 1500iu/ml you might have chances to make it negative with alinia and inactive carriers have hbsag lower than 1500 usually

if you ahven t read alinia thread i had 2500iu/ml hbsag decrease in 4 weeks and another one 2000iu/ml decrease in 3 months,

[cajim]

You have HBV but you are stable.