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HBV DNA drop 5 months post tx
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HBV DNA drop 5 months post tx

Mates,

really strange what's happening to my HBV.. Stopped combo TX (IFN+TDF) 5 months ago after almost 60wks as I still was eag+ and no drop in HBS.

2 months later the DNA increased from UND to 60.000 iu/ml and ALT AST increasd also aourn 70iu/ml .. very weak flare

Latest lab 2 wks ago show HBV DNA 300iu/ml.. while ALT are inside the range (40 range 5 - 50).. I'd hope but i relaly do not believe in any EAG seronconversion.. :(

Stef: have you read this?
http://forum.corriere.it/fegato/17-09-2013/news-dal-congresso-europeo-di-epatologia-2013-epatiti-b-e-d-delta-2401294.html


God bless u all
25 Comments Post a Comment
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Avatar_m_tn
it is probably the effect of pegintf, it still continues after therapy for sometime, very happy you re having a response, is your vit d level still around 100ng/ml?

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Avatar_m_tn
Good to hear. Maybe you did sero-convert to E-Antigen negative because of your normal ALT and low rebound in HBV DNA.

Was it your decision to not continuing with TDF after the combo?

God Bless.

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Avatar_m_tn
to me it seems quite strange that's due to ifn effect..as I stopped in March and i was on 135ng shots... not full does.

@MTP... i do not bet i have serconverted.. possibilties rates are too low...

doc decided to have me on TDF for 1 year only.. then quit TDF 3/4 months before stopping IFN..
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Avatar_m_tn
intf effect will continue for at least another year and in sustained responders for 5 years and more, one thing is certain your immune cells are starting to sense hbv and producing cytokines to abolish replication

do you also have hbsag quant and hbeag quant or will do soon?in bergamo hbsag is about 7€ no need of prescription to make tests if you pay
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Avatar_m_tn
which article do you refer to "in forum corriere fegato"?
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Avatar_m_tn
How long were you on 135mcg G? Also, what are you on right now in term of supplement/diet?

Also, when you were on your first IFN Tx, were you on 180mcg?

I am currently on 90mcg because of the low platelets count.

Not sure when the Dr will allow me to up the dose. My ALT elevate from 50 to 131 max on the first 2 180mcg dose. Last weekly check up, it went down to 91. I will let nature take it's course. Maybe it's our BMI that dictate lower doses. I am 168cm/63kg. So we are both quite small.



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Avatar_m_tn
@ stef: I refer to the study saying 50% of asians and caucasians has DNA drop withn 6 months afetr tx

I do not think my immune system senses the HBV as ALT are normal and monocytes too.. will have hbs quant done soon as wee as eag..

@mtp. My BMI is identical to yours.. I was on 135ng dose during the first course 5 ys ago as well..

I keep on 5000iu VIT D daily...
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Avatar_m_tn
I do not think my immune system senses the HBV as ALT are normal and monocytes too.. will have hbs quant done soon as wee as eag..

this doesn t matter you are not at the stge of infected cells killing but probably only making intf gamma to block replication
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Avatar_m_tn
if possible keep serum levels around 100ng/ml like me and my sister are doing so we get more data on this

as regards calcium we have seen same trend as you with lowering calcium when increasing vitd25oh around 100ng/ml,we re both at 9.2mg/dl
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Avatar_m_tn
i'll have them done soon... do really know whether this is a sign of EAG serocnversion or not... I read the better is to have a high flare before EAG serconversions... not my case
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Avatar_m_tn
what was ur vius count before starting  tenofovir+intf at the begining.
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Avatar_m_tn
also keep in mind the max strenght of immune system on pegintf is after 48weeks and it keeps working even when stopping pegintf, it is very probable you are having some response to the pegintf therapy

the relapse usually happens at the end of the second year so it is best to follow changes with no therapy and when you see a relapse restart tdf
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Avatar_m_tn
let's hope...
@new tr: my DNA has always been >100 000 000 copies/ml since birth to date..
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Avatar_m_tn
similar was my viral load before 3 years before baraclude now undo dna but very high hbsag quantative.i dont know whether i could be benefitted from discontinuation.
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Avatar_m_tn
still dropping.. now is 100iu/ml with normal ALT AST.. but monocites started increasing.. I'll have EAG test next month..keep u posted
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Avatar_m_tn
wow 100iu/ml is definitely a strong immune response i hope this reflects on hbsag too, if it keeps dropping use of antivirals is useless and you may just monitor and keep d3 supplements or try another round of pegintf when hbsag/hbvdna stop the decline
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Avatar_m_tn
please also report all the vitd25oh tests you have, we are trying to check correlation d3 to hbsag/hbvdna when vitd25oh>100ng/ml
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Avatar_m_tn
please tell us your treatment history and results in details.thnks
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Avatar_m_tn
@ newtr.. check my posts to find out treatment i had undergone to..

@ stef.. next month i'll also have vitd25oh.. i keep on intaking 5000iu dailiy.. so I expecti it is in the 80/100 range....
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Avatar_m_tn
---Novemeber... DNA=270iu/ml... starting increasing..
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Avatar_m_tn
--. Dec:  DNA 715iu/ml... increasing..

EAG +ve - HBEAB -ve.... no seroconversion yet...
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Avatar_m_tn
What are you taking complimentary G? Vitamins, herbs, tea....etc?

I understand these have no effects on the virus but some may improve liver condition and boost immune system.

Since you still have not seroconvert, the doc should kept you on TDF. Why were you taken off it. Was it a trial?

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Avatar_m_tn
my liver, accordin to ULTRASOUND is abosultely ok... seems like i'm back to immune tolerant phase...

TDF for me was not a trial... it was a combo therapy with IFN... but i'll believe in 2/3 months there will put me back on antivirals..
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Avatar_m_tn
hi all..

last update..
AST 16 ALT 30 ---- > decreasing
DNA 4000iu -----> increasing..



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Avatar_m_tn
should i be treated again accordin to guidelines? do not think so as ALT are normal...
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